2. PROTAC
  3. Ligands for E3 Ligase
  4. Hydrouracil-4-Iodophenyl

Hydrouracil-4-Iodophenyl is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-4-Iodophenyl can be linked to a target protein ligand via a linker to form a PROTAC.

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Hydrouracil-4-Iodophenyl

Hydrouracil-4-Iodophenyl Chemical Structure

CAS No. : 1528991-21-0

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Hydrouracil-4-Iodophenyl Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

Hydrouracil-4-Iodophenyl is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-4-Iodophenyl can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrouracil-4-Iodophenyl Related Antibodies
Molecular Weight

316.10

Formula

C10H9IN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(=O)CCN1C2=CC=C(I)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
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Hydrouracil-4-Iodophenyl Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrouracil-4-Iodophenyl1528991-21-0Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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