Podofilox
Based on 6 publication(s) in Google Scholar
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 518-28-5
- Formula: C22H22O8
- Molecular Weight:414.41
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
Publications Citing Use of MedChemExpress (MCE) Podofilox
More- ACS Nano. 2024 Mar 19;18(11):8337-8349. [Abstract]
- Cancer Immunol Res. 2023 May 3;11(5):583-599. [Abstract]
- J Ethnopharmacol. 2026 Feb 28:357:120954. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Physiol Res. 2025 Apr 30;74(2):287-300. [Abstract]
- Exp Ther Med. 2021 Nov;22(5):1203. [Abstract]
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Cell Imaging/Staining
-
WB
Biological Activity
Topoisomerase II; Microtubule/Tubulin
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 1A9 | IC50 |
0.003 μM
Compound: podophyllotoxin
|
Cytotoxicity against human 1A9 cells
Cytotoxicity against human 1A9 cells
|
[PMID: 18314944] |
| 786-0 | GI50 |
16.9 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human 786-0 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human 786-0 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| A2780 | IC50 |
18 nM
Compound: 1
|
Cytotoxicity against human A2780 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27518758] |
| A2780 | IC50 |
15 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
|
[PMID: 35344902] |
| A2780 | IC50 |
20 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human A2780AD cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human A2780AD cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
|
[PMID: 35344902] |
| A2780 | IC50 |
15 nM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38294341] |
| A-375 | IC50 |
2.62 μM
Compound: 1
|
Anticancer activity against human A375 cells after 48 hrs by MTT assay
Anticancer activity against human A375 cells after 48 hrs by MTT assay
|
[PMID: 22136907] |
| A-431 | IC50 |
>100 μM
Compound: PDT
|
Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| A-431 | ED50 |
1.1 x 10-6 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human A431 cells by MTT assay
Cytotoxicity against human A431 cells by MTT assay
|
[PMID: 7714533] |
| A-431 | ED50 |
0.03 μg/mL
Compound: 12
|
Cytotoxicity against human A431 cells
Cytotoxicity against human A431 cells
|
[PMID: 8277312] |
| A498 | GI50 |
0.08 μM
Compound: 1
|
In vitro cytotoxic activity against renal (A 498) cancer cell line.
In vitro cytotoxic activity against renal (A 498) cancer cell line.
|
[PMID: 10465531] |
| A498 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human A498 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human A498 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| A498 | IC50 |
0.034 μg/mL
Compound: Podophyllotoxin
|
Anticancer activity against human A498 cells after 24 hrs by MTT assay
Anticancer activity against human A498 cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| A498 | ED50 |
3.4 x 10-7 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human A498 cells by MTT assay
Cytotoxicity against human A498 cells by MTT assay
|
[PMID: 7714533] |
| A549 | IC50 |
0.012 μM
Compound: 1
|
In vitro cytotoxicity against A-549 (human lung carcinoma) cell line.
In vitro cytotoxicity against A-549 (human lung carcinoma) cell line.
|
[PMID: 14971901] |
| A549 | IC50 |
2900 nM
Compound: 2d
|
In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line
In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line
|
[PMID: 14980682] |
| A549 | IC50 |
0.012 μM
Compound: 1
|
Cytotoxicity against human A549 cells after 4 days
Cytotoxicity against human A549 cells after 4 days
|
[PMID: 17197187] |
| A549 | IC50 |
7.63 μM
Compound: 1
|
Cytotoxicity against human A549 cells by sulforhodamine B assay
Cytotoxicity against human A549 cells by sulforhodamine B assay
|
[PMID: 17988764] |
| A549 | IC50 |
7.38 μM
Compound: 1, VP-16
|
Cytotoxicity against human A549 cells after 72 hrs by SRB method
Cytotoxicity against human A549 cells after 72 hrs by SRB method
|
[PMID: 19324555] |
| A549 | IC50 |
0.5 μM
Compound: 2
|
Cytotoxicity against human A549 cells after 24 hrs by MTS assay
Cytotoxicity against human A549 cells after 24 hrs by MTS assay
|
[PMID: 19880222] |
| A549 | IC50 |
0.0043 μg/mL
Compound: 2
|
Growth inhibition of A549 (human lung carcinoma) cell line.
Growth inhibition of A549 (human lung carcinoma) cell line.
|
[PMID: 2002477] |
| A549 | GI50 |
0.012 μM
Compound: 1
|
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
|
[PMID: 20067289] |
| A549 | EC50 |
16.5 nM
Compound: PT
|
Cell cycle arrest in human A549 cells assessed as accumulation of cells in G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry
Cell cycle arrest in human A549 cells assessed as accumulation of cells in G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry
|
[PMID: 21916509] |
| A549 | IC50 |
7.47 nM
Compound: PT
|
Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay
|
[PMID: 21916509] |
| A549 | IC50 |
3.75 μM
Compound: 1
|
Anticancer activity against human A549 cells after 48 hrs by MTT assay
Anticancer activity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 22136907] |
| A549 | GI50 |
13.8 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human A549 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human A549 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| A549 | GI50 |
12 nM
Compound: 1a
|
Growth inhibition of human A549 cells after 72 hrs by SRB assay
Growth inhibition of human A549 cells after 72 hrs by SRB assay
|
[PMID: 22607205] |
| A549 | IC50 |
13.62 μM
Compound: 1
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| A549 | IC50 |
3.6 μM
Compound: 1, Podo
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 23182091] |
| A549 | IC50 |
3.09 μM
Compound: 1
|
Anticancer activity against human A549 cells after 48 hrs by MTT assay
Anticancer activity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 24721832] |
| A549 | IC50 |
0.059 μM
Compound: 2
|
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
|
[PMID: 25084144] |
| A549 | IC50 |
13.62 μM
Compound: Podophyllotoxing
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 25462233] |
| A549 | IC50 |
2.55 μM
Compound: 1
|
Cytotoxicity against human A549 cells assessed as cell viability by SRB assay
Cytotoxicity against human A549 cells assessed as cell viability by SRB assay
|
[PMID: 26022842] |
| A549 | IC50 |
128.61 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 26292628] |
| A549 | IC50 |
0.014 μM
Compound: 2; PPT
|
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
|
[PMID: 26615886] |
| A549 | IC50 |
1.36 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human A549 cells after 36 hrs by MTT assay
Cytotoxicity against human A549 cells after 36 hrs by MTT assay
|
[PMID: 27262599] |
| A549 | IC50 |
15 nM
Compound: 1
|
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 27518758] |
| A549 | IC50 |
0.09 μM
Compound: Podophyllotoxin
|
Growth inhibition of human A549 cells after 48 hrs by MTT assay
Growth inhibition of human A549 cells after 48 hrs by MTT assay
|
[PMID: 28131777] |
| A549 | IC50 |
0.09 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 28648953] |
| A549 | IC50 |
9.34 μM
Compound: 1; PPT
|
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
|
[PMID: 28757065] |
| A549 | IC50 |
3.76 μM
Compound: IV
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 29289881] |
| A549 | IC50 |
4.6 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 29289884] |
| A549 | IC50 |
0.09 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 29525336] |
| A549 | IC50 |
5.61 μM
Compound: PDT
|
Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| A549 | IC50 |
2.6 μM
Compound: PTOX
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| A549 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
|
[PMID: 31546197] |
| A549 | IC50 |
7.34 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
|
[PMID: 31884407] |
| A549 | IC50 |
15.8 nM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
|
[PMID: 32992133] |
| A549 | IC50 |
2.13 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay
|
[PMID: 32992133] |
| A549 | IC50 |
4.31 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
|
[PMID: 32992133] |
| A549 | IC50 |
105 nM
Compound: PPT
|
Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| A549 | IC50 |
291 nM
Compound: PPT
|
Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| A549 | IC50 |
338 nM
Compound: PPT
|
Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| A549 | IC50 |
5.37 nM
Compound: PPT
|
Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
|
[PMID: 34098082] |
| A549 | IC50 |
0.09 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 34175586] |
| A549 | IC50 |
12 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
|
[PMID: 35344902] |
| A549 | IC50 |
0.059 μM
Compound: PPT
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 35447432] |
| A549 | IC50 |
2.6 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38107170] |
| A549 | IC50 |
16 nM
Compound: Podophyllotoxin
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38294341] |
| A549 | IC50 |
0.012 μM
Compound: 1
|
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
|
[PMID: 7673931] |
| A549 | ED50 |
7.7 x 10-8 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
|
[PMID: 7714533] |
| A549 | IC50 |
0.05 μM
Compound: 6 (Podophyllotoxin)
|
Compound was tested for inhibition of cell growth of A-549 cells
Compound was tested for inhibition of cell growth of A-549 cells
|
10.1016/0960-894X(95)00008-H |
| A549 | IC50 |
0.012 μM
Compound: 1 (Podophyllotoxin)
|
Antineoplastic activity against A-549 (human lung carcinoma) cell line.
Antineoplastic activity against A-549 (human lung carcinoma) cell line.
|
10.1016/0960-894X(95)00432-S |
| A549 | IC50 |
<0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay
|
10.1039/C0MD00263A |
| ACHN | IC50 |
2.12 μM
Compound: 1
|
Anticancer activity against human ACHN cells after 48 hrs by MTT assay
Anticancer activity against human ACHN cells after 48 hrs by MTT assay
|
[PMID: 22136907] |
| ACHN | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human ACHN cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human ACHN cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| ACHN | IC50 |
2.3 μM
Compound: 1, Podo
|
Cytotoxicity against human ACHN cells after 72 hrs by MTT assay
Cytotoxicity against human ACHN cells after 72 hrs by MTT assay
|
[PMID: 23182091] |
| ACHN | IC50 |
1.93 μM
Compound: 1
|
Anticancer activity against human ACHN cells after 48 hrs by MTT assay
Anticancer activity against human ACHN cells after 48 hrs by MTT assay
|
[PMID: 24721832] |
| AGS | IC50 |
50.8 μM
Compound: 1, VP-16
|
Cytotoxicity against human AGS cells after 72 hrs by SRB method
Cytotoxicity against human AGS cells after 72 hrs by SRB method
|
[PMID: 19324555] |
| B16 | IC50 |
2.5 μM
Compound: 1, Podo
|
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
|
[PMID: 23182091] |
| B16 | IC50 |
2.12 μM
Compound: 1; PPT
|
Cytotoxicity against human B16 cells after 48 hrs by MTT assay
Cytotoxicity against human B16 cells after 48 hrs by MTT assay
|
[PMID: 30108892] |
| BEAS-2B | IC50 |
14.3 μM
Compound: PPT
|
Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| Bel-7402 | IC50 |
9.1 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human Bel7402 cells after 72 hrs
Antiproliferative activity against human Bel7402 cells after 72 hrs
|
[PMID: 17034133] |
| Bel-7402 | IC50 |
9.1 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human Bel-7402 cells
Antiproliferative activity against human Bel-7402 cells
|
[PMID: 17197178] |
| Bel-7402 | IC50 |
9.1 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human Bel7402 cells
Antiproliferative activity against human Bel7402 cells
|
[PMID: 17482458] |
| Bel-7402 | IC50 |
0.009 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human Bel7402 cells
Antiproliferative activity against human Bel7402 cells
|
[PMID: 17977727] |
| Bel-7402 | IC50 |
0.016 μM
Compound: Podo
|
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| Bel-7402 | IC50 |
0.052 μM
Compound: 1; PPT
|
Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
|
[PMID: 28301815] |
| Bel-7402 | IC50 |
0.04 μM
Compound: Podo
|
Antiproliferation activity against human Bel-7402 cells measured after 72 hrs incubation by MTT assay
Antiproliferation activity against human Bel-7402 cells measured after 72 hrs incubation by MTT assay
|
[PMID: 38781920] |
| Bel7402/5-FU | IC50 |
0.044 μM
Compound: 1; PPT
|
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
|
[PMID: 28301815] |
| BGC-823 | IC50 |
4.31 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human BGC-823 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells incubated for 48 hrs by MTT assay
|
[PMID: 32992133] |
| BJ | IC50 |
>50 μM
Compound: B
|
Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
|
[PMID: 20129783] |
| BJ | IC50 |
5 μM
Compound: PDX
|
Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
|
[PMID: 30482548] |
| BT-549 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human BT549 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human BT549 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| C8166 | EC50 |
0.0029 μM
Compound: 1, podophyllotoxin
|
Antiviral activity against HIV1 in C8166 cells assessed as inhibition of syncytia formation
Antiviral activity against HIV1 in C8166 cells assessed as inhibition of syncytia formation
|
[PMID: 17317161] |
| C8166 | IC50 |
<0.15 μM
Compound: 1, podophyllotoxin
|
Cytotoxicity against C8166 cells assessed as reduction in total cell number
Cytotoxicity against C8166 cells assessed as reduction in total cell number
|
[PMID: 17317161] |
| Caco-2 | IC50 |
0.002 μM
Compound: podophyllotoxin
|
Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay
Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay
|
[PMID: 18586491] |
| Caco-2 | IC50 |
0.5 μM
Compound: 2
|
Cytotoxicity against human Caco-2 cells after 24 hrs by MTS assay
Cytotoxicity against human Caco-2 cells after 24 hrs by MTS assay
|
[PMID: 19880222] |
| CAKI-1 | GI50 |
89.7 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human CAKI-1 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human CAKI-1 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| CAL-51 | GI50 |
0.013 μM
Compound: 1
|
Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay
Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay
|
[PMID: 37849542] |
| Calu-1 | IC50 |
2.68 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay
|
[PMID: 32992133] |
| Ca-Ski | IC50 |
0.3 μM
Compound: PDX
|
Antiproliferative activity against human CaSki cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Antiproliferative activity against human CaSki cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
|
[PMID: 30482548] |
| CCRF-CEM | IC50 |
7.2 nM
Compound: podophyllotoxin
|
Cytotoxicity against human CEM cells
Cytotoxicity against human CEM cells
|
[PMID: 17197178] |
| CCRF-CEM | IC50 |
7.2 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human CEM cells
Antiproliferative activity against human CEM cells
|
[PMID: 17482458] |
| CCRF-CEM | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human CCRF-CEM cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human CCRF-CEM cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Col2 | ED50 |
0.005 μg/mL
Compound: 12
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 8277312] |
| COLO 205 | IC50 |
5 μM
Compound: 1
|
Cytotoxicity against human COLO205 assessed as inhibition of cell growth
Cytotoxicity against human COLO205 assessed as inhibition of cell growth
|
[PMID: 21144748] |
| COLO 205 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human COLO205 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human COLO205 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| CV-1 | IC50 |
0.05 μM
Compound: 4
|
Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation
Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation
|
[PMID: 9834179] |
| CV-1 | IC50 |
0.029 μM
Compound: 1 (Podophyllotoxin)
|
Antineoplastic activity against CV-1 (monkey kidney fibroblast) cell line.
Antineoplastic activity against CV-1 (monkey kidney fibroblast) cell line.
|
10.1016/0960-894X(95)00432-S |
| DLD-1 | IC50 |
0.11 μM
Compound: PDT
|
Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| DMS-79 | IC50 |
23 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human DMS79 cells after 72 hrs
Antiproliferative activity against human DMS79 cells after 72 hrs
|
[PMID: 17034133] |
| DU-145 | GI50 |
0.04 μM
Compound: 1
|
In vitro cytotoxic activity against prostate (DU-145) cancer cell line.
In vitro cytotoxic activity against prostate (DU-145) cancer cell line.
|
[PMID: 10465531] |
| DU-145 | IC50 |
52 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human DU145 cells after 72 hrs
Antiproliferative activity against human DU145 cells after 72 hrs
|
[PMID: 17034133] |
| DU-145 | IC50 |
52 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
|
[PMID: 17197178] |
| DU-145 | IC50 |
52 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
|
[PMID: 17482458] |
| DU-145 | IC50 |
0.052 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
|
[PMID: 17977727] |
| DU-145 | IC50 |
2.97 μM
Compound: 1
|
Cytotoxicity against human DU145 cells by sulforhodamine B assay
Cytotoxicity against human DU145 cells by sulforhodamine B assay
|
[PMID: 17988764] |
| DU-145 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human DU145 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human DU145 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| DU-145 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| DU-145 | IC50 |
3.21 μM
Compound: 1
|
Anticancer activity against human DU145 cells after 48 hrs by MTT assay
Anticancer activity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 24721832] |
| DU-145 | IC50 |
>100 μM
Compound: Podophyllotoxing
|
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 25462233] |
| DU-145 | IC50 |
0.01 μM
Compound: PPT
|
Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay
Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| DU-145 | IC50 |
0.063 μM
Compound: Podophyllotoxin
|
Growth inhibition of human DU145 cells after 48 hrs by MTT assay
Growth inhibition of human DU145 cells after 48 hrs by MTT assay
|
[PMID: 28131777] |
| DU-145 | IC50 |
0.063 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 28648953] |
| DU-145 | IC50 |
3.11 μM
Compound: IV
|
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 29289881] |
| DU-145 | IC50 |
4.15 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 29289884] |
| DU-145 | IC50 |
0.063 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 29525336] |
| DU-145 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human DU145 cells by MTT assay
Antiproliferative activity against human DU145 cells by MTT assay
|
[PMID: 31546197] |
| DU-145 | IC50 |
0.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 34175586] |
| DU-145 | IC50 |
<0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay
|
10.1039/C0MD00263A |
| EKVX | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human EKVX cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human EKVX cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Erythrocyte | IC50 |
7 ng/mL
Compound: podophyllotoxin
|
Cytotoxicity against human erythrocytes
Cytotoxicity against human erythrocytes
|
[PMID: 19199815] |
| FaDu | IC50 |
7.2 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human CEM cells after 72 hrs
Antiproliferative activity against human CEM cells after 72 hrs
|
[PMID: 17034133] |
| GLC4 cell line | IC50 |
0.06 μM
Compound: 20
|
Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation
Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation
|
[PMID: 7783142] |
| GLC4 cell line | IC50 |
0.15 μM
Compound: 20
|
Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation
Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation
|
[PMID: 7783142] |
| HCC 2998 | GI50 |
12.3 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HCC2998 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HCC2998 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| HCC 2998 | GI50 |
0.2 μM
Compound: 1
|
In vitro cytotoxicity against human colon cancer HCC 2998 cell line
In vitro cytotoxicity against human colon cancer HCC 2998 cell line
|
[PMID: 9871772] |
| HCT-116 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HCT116 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HCT116 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| HCT-116 | IC50 |
0.01 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HCT116
Cytotoxicity against human HCT116
|
[PMID: 26916436] |
| HCT-116 | IC50 |
0.02 μM
Compound: PPT
|
Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| HCT-116 | IC50 |
>20 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
|
[PMID: 31884407] |
| HCT-116 | GI50 |
0.013 μM
Compound: 1
|
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay
|
[PMID: 37849542] |
| HCT-116 | GI50 |
0.01 μM
Compound: 1
|
In vitro cytotoxicity against human colon cancer HCT 116 cell line
In vitro cytotoxicity against human colon cancer HCT 116 cell line
|
[PMID: 9871772] |
| HCT-15 | IC50 |
1 μM
Compound: 1
|
Cytotoxicity against human HCT-15 cells by sulforhodamine B assay
Cytotoxicity against human HCT-15 cells by sulforhodamine B assay
|
[PMID: 17988764] |
| HCT-15 | GI50 |
13.5 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HCT15 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HCT15 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| HCT-15 | IC50 |
0.061 μM
Compound: Podophyllotoxin
|
Growth inhibition of human HCT15 cells after 48 hrs by MTT assay
Growth inhibition of human HCT15 cells after 48 hrs by MTT assay
|
[PMID: 28131777] |
| HCT-15 | IC50 |
0.061 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay
|
[PMID: 28648953] |
| HCT-15 | GI50 |
0.02 μM
Compound: 1
|
In vitro cytotoxicity against human colon cancer HCT 15 cell line
In vitro cytotoxicity against human colon cancer HCT 15 cell line
|
[PMID: 9871772] |
| HCT-8 | IC50 |
1.68 μM
Compound: PPT
|
Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| HEK293 | IC50 |
0.017 μM
Compound: B
|
Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
|
[PMID: 20129783] |
| HEK293 | IC50 |
50 μM
Compound: PDT
|
Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
|
[PMID: 24457094] |
| HEK293 | IC50 |
0.12 μg/mL
Compound: Podophyllotoxin
|
Cytotoxic activity against HEK293 cells after 24 hrs by MTT assay
Cytotoxic activity against HEK293 cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| HEK-293T | IC50 |
1.54 μM
Compound: Podophyllotoxin
|
Cytotoxicity against HEK293T cells after 36 hrs by MTT assay
Cytotoxicity against HEK293T cells after 36 hrs by MTT assay
|
[PMID: 27262599] |
| HEK-293T | IC50 |
20 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 37550948] |
| HeLa | ED50 |
20.5 μg/mL
Compound: 3
|
Cytotoxicity against human HeLa cells after 4 days by trypan blue assay
Cytotoxicity against human HeLa cells after 4 days by trypan blue assay
|
[PMID: 1602298] |
| HeLa | GI50 |
0.02 μM
Compound: 1
|
Growth inhibition of HeLa cells after 48 hrs by MTT assay
Growth inhibition of HeLa cells after 48 hrs by MTT assay
|
[PMID: 17894480] |
| HeLa | IC50 |
0.069 μM
Compound: 6
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 21570846] |
| HeLa | GI50 |
0.02 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 21615090] |
| HeLa | IC50 |
0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HeLa cells after 2 days by MTT assay
Cytotoxicity against human HeLa cells after 2 days by MTT assay
|
[PMID: 21821321] |
| HeLa | IC50 |
7.58 μM
Compound: 1
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| HeLa | IC50 |
0.14 μM
Compound: 1
|
Cytotoxicity against human HeLa cells after 48 hrs
Cytotoxicity against human HeLa cells after 48 hrs
|
[PMID: 23022053] |
| HeLa | IC50 |
2.8 μM
Compound: 1, Podo
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 23182091] |
| HeLa | IC50 |
2.81 μM
Compound: 1
|
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 24721832] |
| HeLa | GI50 |
0.71 μM
Compound: 1
|
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
|
[PMID: 24953821] |
| HeLa | IC50 |
0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 25113878] |
| HeLa | GI50 |
0.74 μM
Compound: 1
|
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay
|
[PMID: 25131956] |
| HeLa | IC50 |
3.14 μg/mL
Compound: Podophyllotoxin
|
Anticancer activity against human HeLa cells after 24 hrs by MTT assay
Anticancer activity against human HeLa cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| HeLa | IC50 |
7.58 μM
Compound: Podophyllotoxing
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 25462233] |
| HeLa | IC50 |
1.92 μM
Compound: 1
|
Cytotoxicity against human HeLa cells assessed as cell viability by SRB assay
Cytotoxicity against human HeLa cells assessed as cell viability by SRB assay
|
[PMID: 26022842] |
| HeLa | IC50 |
0.012 μM
Compound: 2; PPT
|
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay
|
[PMID: 26615886] |
| HeLa | IC50 |
1.45 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HeLa cells after 36 hrs by MTT assay
Cytotoxicity against human HeLa cells after 36 hrs by MTT assay
|
[PMID: 27262599] |
| HeLa | IC50 |
7.45 μM
Compound: 1; PPT
|
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
|
[PMID: 28757065] |
| HeLa | IC50 |
3.04 μM
Compound: IV
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 29289881] |
| HeLa | IC50 |
3.45 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 29289884] |
| HeLa | IC50 |
2.36 μM
Compound: 1; PPT
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 30108892] |
| HeLa | IC50 |
6.9 μM
Compound: PTOX
|
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| HeLa | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
|
[PMID: 31546197] |
| HeLa | IC50 |
2.13 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay
|
[PMID: 32992133] |
| HeLa | IC50 |
14 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human HeLa cells overexpressing tubulin beta3 assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells overexpressing tubulin beta3 assessed as inhibition of cell growth measured after 48 hrs by MTT assay
|
[PMID: 35344902] |
| HeLa | IC50 |
17 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
|
[PMID: 35344902] |
| HeLa | IC50 |
0.044 μM
Compound: PPT
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 35447432] |
| HeLa | IC50 |
6.9 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth
|
[PMID: 38107170] |
| HeLa | IC50 |
15.5 nM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38294341] |
| HeLa | IC50 |
18 nM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38294341] |
| HEp-2 | IC50 |
1.42 μM
Compound: 1
|
Cytotoxicity against human HEP2 cells by sulforhodamine B assay
Cytotoxicity against human HEP2 cells by sulforhodamine B assay
|
[PMID: 17988764] |
| HepG2 | IC50 |
4.8 μM
Compound: podophyllotoxin
|
Cytotoxicity against human HEPG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HEPG2 cells after 24 hrs by MTT assay
|
[PMID: 18586491] |
| HepG2 | IC50 |
0.5 μM
Compound: 2
|
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
|
[PMID: 19880222] |
| HepG2 | IC50 |
0.024 μM
Compound: B
|
Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
|
[PMID: 20129783] |
| HepG2 | IC50 |
2.27 μM
Compound: 1
|
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| HepG2 | IC50 |
0.51 μM
Compound: 1
|
Cytotoxicity against human HepG2 cells after 48 hrs
Cytotoxicity against human HepG2 cells after 48 hrs
|
[PMID: 23022053] |
| HepG2 | IC50 |
2.27 μM
Compound: Podophyllotoxing
|
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 25462233] |
| HepG2 | IC50 |
0.014 μM
Compound: 2; PPT
|
Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
|
[PMID: 26615886] |
| HepG2 | IC50 |
0.003 μM
Compound: Podo
|
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| HepG2 | IC50 |
5.81 μM
Compound: 1; PPT
|
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
|
[PMID: 28757065] |
| HepG2 | IC50 |
6.63 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 29289884] |
| HepG2 | IC50 |
0.008 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 29609908] |
| HepG2 | IC50 |
2.4 μM
Compound: PTOX
|
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| HepG2 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
|
[PMID: 31546197] |
| HepG2 | CC50 |
<0.5 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
|
[PMID: 32527539] |
| HepG2 | IC50 |
4.31 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
|
[PMID: 32992133] |
| HepG2 | IC50 |
209 nM
Compound: PPT
|
Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| HepG2 | IC50 |
83 nM
Compound: PPT
|
Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| HepG2 | IC50 |
>200000 nM
Compound: PPT
|
Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
|
[PMID: 34098082] |
| HepG2 | IC50 |
19.6 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 37550948] |
| HepG2 | IC50 |
2.4 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 38107170] |
| HepG2 | IC50 |
<0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by SRB assay
|
10.1039/C0MD00263A |
| HL-60 | IC50 |
2.75 μM
Compound: 1, VP-16
|
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
|
[PMID: 19324555] |
| HL-60 | IC50 |
0.48 μM
Compound: PPT
|
Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay
Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| HL-60(TB) | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HL-60(TB) cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HL-60(TB) cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| HMEC | IC50 |
5.6 μM
Compound: PTOX
|
Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| HMEC | IC50 |
1338 nM
Compound: PPT
|
Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay
Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay
|
[PMID: 34098082] |
| HOP-62 | IC50 |
13.1 μM
Compound: 1
|
Cytotoxicity against human HOP62 assessed as inhibition of cell growth
Cytotoxicity against human HOP62 assessed as inhibition of cell growth
|
[PMID: 21144748] |
| HOP-62 | GI50 |
21.1 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HOP62 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HOP62 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| HOP-92 | GI50 |
34.1 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HOP92 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HOP92 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Hs-578T | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human Hs 578T cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human Hs 578T cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Hs-578T | GI50 |
0.08 μM
Compound: 1
|
In vitro cytotoxicity against human breast cancer Hs 578.T cell line
In vitro cytotoxicity against human breast cancer Hs 578.T cell line
|
[PMID: 9871772] |
| HT | ED50 |
0.003 μg/mL
Compound: 12
|
Cytotoxicity against human HT cells
Cytotoxicity against human HT cells
|
[PMID: 8277312] |
| HT-1080 | IC50 |
8.1 μM
Compound: 1
|
Cytotoxicity against human HT1080 assessed as inhibition of cell growth
Cytotoxicity against human HT1080 assessed as inhibition of cell growth
|
[PMID: 21144748] |
| HT-29 | IC50 |
0.024 μM
Compound: 1
|
In vitro cytotoxicity against HT-29 (human colon carcinoma) cell line.
In vitro cytotoxicity against HT-29 (human colon carcinoma) cell line.
|
[PMID: 14971901] |
| HT-29 | IC50 |
2900 nM
Compound: 2d
|
In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line
In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line
|
[PMID: 14980682] |
| HT-29 | IC50 |
0.012 μM
Compound: 1
|
Cytotoxicity against human HT29 cells after 4 days
Cytotoxicity against human HT29 cells after 4 days
|
[PMID: 17197187] |
| HT-29 | IC50 |
0.0043 μg/mL
Compound: 2
|
Growth inhibition of HT-29 (human colon adenocarcinoma) cell line.
Growth inhibition of HT-29 (human colon adenocarcinoma) cell line.
|
[PMID: 2002477] |
| HT-29 | GI50 |
0.024 μM
Compound: 1
|
Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay
|
[PMID: 20067289] |
| HT-29 | IC50 |
0.78 μM
Compound: 1
|
Anticancer activity against human HT-29 cells after 48 hrs by MTT assay
Anticancer activity against human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 22136907] |
| HT-29 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human HT-29 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HT-29 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| HT-29 | GI50 |
12 nM
Compound: 1a
|
Growth inhibition of human HT-29 cells after 72 hrs by SRB assay
Growth inhibition of human HT-29 cells after 72 hrs by SRB assay
|
[PMID: 22607205] |
| HT-29 | IC50 |
1.02 μM
Compound: 1, Podo
|
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
|
[PMID: 23182091] |
| HT-29 | IC50 |
2.29 μM
Compound: 1
|
Anticancer activity against human HT-29 cells after 48 hrs by MTT assay
Anticancer activity against human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 24721832] |
| HT-29 | IC50 |
0.02 μM
Compound: PPT
|
Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay
Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| HT-29 | IC50 |
11 nM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
|
[PMID: 2778449] |
| HT-29 | IC50 |
2.99 μM
Compound: IV
|
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 29289881] |
| HT-29 | IC50 |
4.78 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 29289884] |
| HT-29 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human HT-29 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method
Cytotoxicity against human HT-29 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method
|
[PMID: 29670695] |
| HT-29 | IC50 |
0.066 μM
Compound: 1
|
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
|
[PMID: 29670695] |
| HT-29 | IC50 |
1.26 μM
Compound: 1; PPT
|
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 30108892] |
| HT-29 | IC50 |
0.023 μM
Compound: PPT
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 35447432] |
| HT-29 | IC50 |
1.75 μM
Compound: PPT
|
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| HT-29 | IC50 |
0.0029 μM
Compound: 1
|
Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
|
[PMID: 7673931] |
| HT-29 | ED50 |
4.7 x 10-8 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human HT-29 cells by MTT assay
Cytotoxicity against human HT-29 cells by MTT assay
|
[PMID: 7714533] |
| HT-29 | GI50 |
0.01 μM
Compound: 1
|
In vitro cytotoxicity against human colon cancer HT 29 cell line
In vitro cytotoxicity against human colon cancer HT 29 cell line
|
[PMID: 9871772] |
| HT-29 | IC50 |
0.05 μM
Compound: 6 (Podophyllotoxin)
|
Compound was tested for inhibition of cell growth of HT-29 cells
Compound was tested for inhibition of cell growth of HT-29 cells
|
10.1016/0960-894X(95)00008-H |
| HT-29 | IC50 |
0.029 μM
Compound: 1 (Podophyllotoxin)
|
Antineoplastic activity against HT-29 (human colon carcinoma) cell line.
Antineoplastic activity against HT-29 (human colon carcinoma) cell line.
|
10.1016/0960-894X(95)00432-S |
| HUVEC | IC50 |
0.014 μM
Compound: 2; PPT
|
Antiproliferative activity against HUVEC assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against HUVEC assessed as growth inhibition after 72 hrs by CCK-8 assay
|
[PMID: 26615886] |
| IGROV-1 | GI50 |
13.2 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human IGROV1 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human IGROV1 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| J774 | IC50 |
18 nM
Compound: Podophyllotoxin
|
Cytotoxicity against mouse J774 cells
Cytotoxicity against mouse J774 cells
|
[PMID: 22765899] |
| J774 | IC50 |
0.023 μM
Compound: Podophyllotoxin
|
Cytotoxicity against mouse J774 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against mouse J774 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31732409] |
| J774 | IC50 |
16.4 nM
Compound: Podophyllotoxin
|
Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells
Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells
|
10.1016/0960-894X(95)00300-I |
| J774.2 | IC50 |
11.3 nM
Compound: Podophyllotoxin
|
Inhibitory concentration required for cytotoxicity in hydroxyrubicin-resistant (WP159/R) cells
Inhibitory concentration required for cytotoxicity in hydroxyrubicin-resistant (WP159/R) cells
|
10.1016/0960-894X(95)00300-I |
| J774.2 | IC50 |
13.4 nM
Compound: Podophyllotoxin
|
Inhibitory concentration required for cytotoxicity in DOX-resistant (DOX/R) cells
Inhibitory concentration required for cytotoxicity in DOX-resistant (DOX/R) cells
|
10.1016/0960-894X(95)00300-I |
| J774.A1 | EC50 |
250 nM
Compound: Podophyllotoxin
|
Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay
|
[PMID: 24874647] |
| J774.A1 | EC50 |
21 nM
Compound: Podophyllotoxin
|
Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
|
[PMID: 25749014] |
| J774.A1 | EC50 |
250 nM
Compound: Podophyllotoxin
|
Cytotoxicity against mouse J774.A1 cells
Cytotoxicity against mouse J774.A1 cells
|
[PMID: 38909569] |
| Jurkat | IC50 |
25 nM
Compound: PT
|
Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay
|
[PMID: 21916509] |
| Jurkat | IC50 |
25 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
|
[PMID: 22370267] |
| K562 | IC50 |
>100 μM
Compound: 1, VP-16
|
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
|
[PMID: 19324555] |
| K562 | IC50 |
0.35 μM
Compound: Podophyllotoxin
|
Inhibition of tubulin polymerization in human K562 cells
Inhibition of tubulin polymerization in human K562 cells
|
[PMID: 20546980] |
| K562 | IC50 |
0.03 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human K562 cells after 2 days by MTT assay
Cytotoxicity against human K562 cells after 2 days by MTT assay
|
[PMID: 21821321] |
| K562 | GI50 |
215.3 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human K562 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human K562 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| K562 | IC50 |
4.51 μM
Compound: 1
|
Cytotoxicity against human K562 cells after 48 hrs
Cytotoxicity against human K562 cells after 48 hrs
|
[PMID: 23022053] |
| K562 | IC50 |
0.03 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
|
[PMID: 25113878] |
| K562 | IC50 |
0.013 μg/mL
Compound: Podophyllotoxin
|
Anticancer activity against human K562 cells after 24 hrs by MTT assay
Anticancer activity against human K562 cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| K562 | IC50 |
0.006 μM
Compound: 2; PPT
|
Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
|
[PMID: 26615886] |
| K562 | IC50 |
0.006 μM
Compound: 1; PPT
|
Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
|
[PMID: 27503681] |
| K562 | IC50 |
0.025 μM
Compound: 1
|
Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
|
[PMID: 29678463] |
| K562 | IC50 |
18.39 μM
Compound: PDT
|
Cytotoxicity against human K562 cells incubated for 72 hrs by Sulphorhodamine assay
Cytotoxicity against human K562 cells incubated for 72 hrs by Sulphorhodamine assay
|
[PMID: 37146520] |
| K562/A02 | IC50 |
0.17 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human K562/A02 cells after 2 days by MTT assay
Cytotoxicity against human K562/A02 cells after 2 days by MTT assay
|
[PMID: 21821321] |
| K562/A02 | IC50 |
0.17 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay
Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay
|
[PMID: 25113878] |
| K562/Adr | IC50 |
0.085 μM
Compound: 2; PPT
|
Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay
|
[PMID: 26615886] |
| K562/Adr | IC50 |
0.025 μM
Compound: 1; PPT
|
Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay
Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay
|
[PMID: 27503681] |
| K562/VCR | IC50 |
0.05 μM
Compound: 1
|
Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay
Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay
|
[PMID: 29678463] |
| KB | IC50 |
0.008 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
|
[PMID: 11141105] |
| KB | IC50 |
0.006 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 11421727] |
| KB | ED50 |
0.2 nM
Compound: Podophyllotoxin
|
The toxicity was evaluated against KB cells
The toxicity was evaluated against KB cells
|
[PMID: 11459645] |
| KB | ED50 |
0.008 μg/mL
Compound: Podophyllotoxin
|
Toxicity of the quinacrine derivatives was determined against the KB cell line in comparison to podophyllotoxin
Toxicity of the quinacrine derivatives was determined against the KB cell line in comparison to podophyllotoxin
|
[PMID: 11551771] |
| KB | IC50 |
0.0048 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells by alamar blue assay
Cytotoxicity against human KB cells by alamar blue assay
|
[PMID: 12141852] |
| KB | IC50 |
6.21 ng/mL
Compound: podophyllotoxin
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 12398543] |
| KB | IC50 |
6.21 x 10-3 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 12398543] |
| KB | IC50 |
0.005 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 15104480] |
| KB | ED50 |
0.07 μM
Compound: podophyllotoxin
|
Cytotoxicity against human KB cells by Alamar blue assay
Cytotoxicity against human KB cells by Alamar blue assay
|
[PMID: 16279799] |
| KB | IC50 |
0.0036 μM
Compound: podophyllotoxin
|
Cytotoxicity against KB cell line
Cytotoxicity against KB cell line
|
[PMID: 16343898] |
| KB | CC50 |
0.048 μM
Compound: podophylotoxin
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 17548196] |
| KB | IC50 |
0.003 μM
Compound: POD
|
Cytotoxicity against human KB cells after 48 hrs by alamar blue assay
Cytotoxicity against human KB cells after 48 hrs by alamar blue assay
|
[PMID: 18215443] |
| KB | ED50 |
<0.3 μg/mL
Compound: 18 (-)-Podophyllotoxin
|
In vitro effective dose to inhibit KB cell growth from a human epidermoid carcinoma.
In vitro effective dose to inhibit KB cell growth from a human epidermoid carcinoma.
|
[PMID: 1992152] |
| KB | IC50 |
0.056 μM
Compound: 6
|
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
|
[PMID: 21570846] |
| KB | IC50 |
0.0005 μM
Compound: POD
|
Cytotoxicity against human KB cells assessed as growth inhibition
Cytotoxicity against human KB cells assessed as growth inhibition
|
[PMID: 21705220] |
| KB | IC50 |
0.5 nM
Compound: POD
|
Cytotoxicity against human KB cells assessed as growth inhibition
Cytotoxicity against human KB cells assessed as growth inhibition
|
[PMID: 21705220] |
| KB | IC50 |
11.7 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay
|
[PMID: 24148834] |
| KB | IC50 |
0.0007 μM
Compound: POD
|
Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
|
[PMID: 24900724] |
| KB | IC50 |
0.7 nM
Compound: POD
|
Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
|
[PMID: 24900724] |
| KB | IC50 |
0.058 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
|
[PMID: 28189085] |
| KB | IC50 |
0.002 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells assessed as reduction in cell viability
Cytotoxicity against human KB cells assessed as reduction in cell viability
|
[PMID: 31515186] |
| KB | IC50 |
3.21 nM
Compound: Podo
|
Antiproliferation activity against human KB cells measured after 72 hrs incubation by MTT assay
Antiproliferation activity against human KB cells measured after 72 hrs incubation by MTT assay
|
[PMID: 38781920] |
| KB | ED50 |
<1 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 7130986] |
| KB | ED50 |
0.0003 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
|
[PMID: 8158163] |
| KB | ED50 |
0.3 ng/mL
Compound: Podophyllotoxin
|
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
|
[PMID: 8158163] |
| KB | ED50 |
0.08 μg/mL
Compound: 12
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 8277312] |
| KB-V1 | ED50 |
0.06 μg/mL
Compound: 12
|
Cytotoxicity against human KBV1 cells
Cytotoxicity against human KBV1 cells
|
[PMID: 8277312] |
| KM12 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human KM12 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human KM12 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| KM12 | GI50 |
0.01 μM
Compound: 1
|
In vitro cytotoxicity against human colon cancer KM 12 cell line
In vitro cytotoxicity against human colon cancer KM 12 cell line
|
[PMID: 9871772] |
| L02 | IC50 |
0.022 μM
Compound: 1; PPT
|
Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
|
[PMID: 28301815] |
| L02 | IC50 |
3.72 μM
Compound: 1; PPT
|
Cytotoxicity against human L02 cells after 24 hrs by MTT assay
Cytotoxicity against human L02 cells after 24 hrs by MTT assay
|
[PMID: 28757065] |
| L02 | IC50 |
5 μM
Compound: PTOX
|
Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| L02 | IC50 |
2.97 μM
Compound: Ref 34, Cpd 1
|
Cytotoxicity against human L02 cells incubated for 24 hrs by CCK8 assay
Cytotoxicity against human L02 cells incubated for 24 hrs by CCK8 assay
|
[PMID: 32992133] |
| L02 | IC50 |
3.16 μM
Compound: Ref 34, Cpd 1
|
Cytotoxicity against human L02 cells
Cytotoxicity against human L02 cells
|
[PMID: 32992133] |
| L02 | IC50 |
4.31 μM
Compound: Ref 34, Cpd 1
|
Cytotoxicity against human HL7702 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HL7702 cells incubated for 48 hrs by MTT assay
|
[PMID: 32992133] |
| L02 | IC50 |
85 nM
Compound: PPT
|
Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33091789] |
| L02 | IC50 |
32.76 nM
Compound: Podo
|
Antiproliferation activity against human L02 cells measured after 72 hrs incubation by MTT assay
Antiproliferation activity against human L02 cells measured after 72 hrs incubation by MTT assay
|
[PMID: 38781920] |
| L1210 | IC50 |
0.0036 μg/mL
Compound: 1
|
Tested for in vitro cytotoxicity against L1210 murine leukemia cells in mice
Tested for in vitro cytotoxicity against L1210 murine leukemia cells in mice
|
10.1016/0960-894X(95)00172-P |
| L6 | IC50 |
0.018 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 15921407] |
| L6 | IC50 |
0.15 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 16677813] |
| L6 | IC50 |
0.012 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 16821778] |
| L6 | IC50 |
0.005 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 17253841] |
| L6 | IC50 |
0.0186 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 17439202] |
| L6 | IC50 |
0.006 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 4 days
Cytotoxicity against rat L6 cells after 4 days
|
[PMID: 17475370] |
| L6 | IC50 |
0.014 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay
Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay
|
[PMID: 17709461] |
| L6 | IC50 |
0.009 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs
Cytotoxicity against rat L6 cells after 72 hrs
|
[PMID: 17765547] |
| L6 | IC50 |
0.019 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells by Alamar blue assay
Cytotoxicity against rat L6 cells by Alamar blue assay
|
[PMID: 17922552] |
| L6 | IC50 |
0.01 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 17948982] |
| L6 | IC50 |
0.01 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 17949068] |
| L6 | IC50 |
0.007 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 17990865] |
| L6 | IC50 |
0.02 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 18476684] |
| L6 | IC50 |
0.012 μM
Compound: Pod
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 18571774] |
| L6 | IC50 |
0.006 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 18683985] |
| L6 | IC50 |
0.019 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 18841956] |
| L6 | IC50 |
0.007 μg/mL
Compound: Pod
|
Cytotoxicity against rat L6 cells by alamar blue assay
Cytotoxicity against rat L6 cells by alamar blue assay
|
[PMID: 19010569] |
| L6 | IC50 |
0.008 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 19015351] |
| L6 | IC50 |
0.01 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 19267462] |
| L6 | IC50 |
0.017 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 19409677] |
| L6 | IC50 |
0.012 μM
Compound: 19
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 19414258] |
| L6 | IC50 |
0.01 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 19606902] |
| L6 | IC50 |
0.012 μM
Compound: podophyllotoxin
|
Toxicity against rat L6 cells
Toxicity against rat L6 cells
|
[PMID: 19781948] |
| L6 | IC50 |
0.02 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 19928900] |
| L6 | IC50 |
0.01 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 19942439] |
| L6 | IC50 |
0.012 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 20047276] |
| L6 | EC50 |
14 nM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 20185305] |
| L6 | IC50 |
0.007 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 20307077] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 20850207] |
| L6 | IC50 |
0.004 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometric analysis
Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometric analysis
|
[PMID: 20855214] |
| L6 | IC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 21112788] |
| L6 | IC50 |
0.01 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 21348447] |
| L6 | IC50 |
0.012 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry
Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry
|
[PMID: 21438586] |
| L6 | IC50 |
0.021 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells by MTT assay
Cytotoxicity against rat L6 cells by MTT assay
|
[PMID: 21456549] |
| L6 | IC50 |
0.009 μM
Compound: podophyllotoxin
|
Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay
Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay
|
[PMID: 21644541] |
| L6 | IC50 |
0.019 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells incubated for 72 hrs by Alamar Blue staining based fluorometric assay
Cytotoxicity against rat L6 cells incubated for 72 hrs by Alamar Blue staining based fluorometric assay
|
[PMID: 21846091] |
| L6 | IC50 |
0.02 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 21868222] |
| L6 | IC50 |
0.014 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 21937228] |
| L6 | IC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay
Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay
|
[PMID: 22061825] |
| L6 | IC50 |
0.007 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay
Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay
|
[PMID: 22217867] |
| L6 | IC50 |
0.01 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay
|
[PMID: 22285027] |
| L6 | IC50 |
0.004 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 22352841] |
| L6 | EC50 |
0.012 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 22390399] |
| L6 | IC50 |
0.022 μM
Compound: podoph
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 22550999] |
| L6 | IC50 |
0.019 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 22738640] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 22932312] |
| L6 | IC50 |
0.0017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy
|
[PMID: 23153330] |
| L6 | IC50 |
0.019 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 23265884] |
| L6 | IC50 |
0.0145 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by resazurin reduction assay
Cytotoxicity against rat L6 cells after 70 hrs by resazurin reduction assay
|
[PMID: 23301592] |
| L6 | IC50 |
0.005 μg/mL
Compound: Podophyllotoxin
|
Toxicity against rat L6 cells after 72 hrs by Alamar blue assay
Toxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 23313632] |
| L6 | IC50 |
0.008 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by microscopic analysis
Cytotoxicity against rat L6 cells after 70 hrs by microscopic analysis
|
[PMID: 23320609] |
| L6 | IC50 |
14.5 nM
Compound: Podophylotoxin
|
Toxicity against rat L6 cells after 72 hrs by Alamar blue assay
Toxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 23360309] |
| L6 | EC50 |
0.009 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 23517371] |
| L6 | IC50 |
14.5 nM
Compound: Podophylotoxin
|
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis
|
[PMID: 23685569] |
| L6 | IC50 |
0.017 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
|
[PMID: 23795673] |
| L6 | EC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay
|
[PMID: 23831695] |
| L6 | IC50 |
0.019 mM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 23871911] |
| L6 | EC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
|
[PMID: 23916149] |
| L6 | IC50 |
0.01 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 23968432] |
| L6 | IC50 |
0.006 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis
|
[PMID: 24063369] |
| L6 | IC50 |
0.017 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay
|
[PMID: 24268543] |
| L6 | CC50 |
0.014 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 48 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 48 hrs by Alamar Blue assay
|
[PMID: 24354316] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar Blue assay
|
[PMID: 24471526] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 24673206] |
| L6 | IC50 |
14.5 nM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay
|
[PMID: 24721829] |
| L6 | IC50 |
0.014 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 24865793] |
| L6 | IC50 |
0.0193 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis
Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis
|
[PMID: 24900574] |
| L6 | IC50 |
0.001 μM
Compound: PDT
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 24900706] |
| L6 | IC50 |
0.02 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay
|
[PMID: 24900723] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay
Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay
|
[PMID: 24956553] |
| L6 | EC50 |
0.007 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 24978605] |
| L6 | IC50 |
0.02 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25080196] |
| L6 | IC50 |
0.02 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25103602] |
| L6 | IC50 |
0.0097 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 25195945] |
| L6 | IC50 |
0.02 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25314007] |
| L6 | IC50 |
5 nM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25547934] |
| L6 | IC50 |
19 nM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25563890] |
| L6 | CC50 |
0.012 μM
Compound: podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25642604] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 25740635] |
| L6 | IC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 25871440] |
| L6 | IC50 |
0.002 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 26237241] |
| L6 | EC50 |
0.005 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells incubated for 72 hrs by alamar blue staining based microscopy
Cytotoxicity against rat L6 cells incubated for 72 hrs by alamar blue staining based microscopy
|
[PMID: 26408453] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by AlamarBlue dye based fluorimetric method
Cytotoxicity against rat L6 cells after 72 hrs by AlamarBlue dye based fluorimetric method
|
[PMID: 26849852] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis
Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis
|
[PMID: 27102161] |
| L6 | IC50 |
0.012 μM
Compound: POD
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay
|
[PMID: 27344215] |
| L6 | IC50 |
0.0169 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells by alamar blue assay
Cytotoxicity against rat L6 cells by alamar blue assay
|
[PMID: 27387356] |
| L6 | IC50 |
0.012 μM
Compound: POD
|
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay
|
[PMID: 28031151] |
| L6 | IC50 |
0.016 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
|
[PMID: 28116906] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
|
[PMID: 28121440] |
| L6 | IC50 |
0.012 μM
Compound: POD
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay
|
[PMID: 28279559] |
| L6 | IC50 |
0.014 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay
|
[PMID: 28284860] |
| L6 | IC50 |
0.0082 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 28537728] |
| L6 | IC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 28666857] |
| L6 | IC50 |
0.01 μM
Compound: PDP
|
Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay
|
[PMID: 28789893] |
| L6 | IC50 |
0.01 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 28840725] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based assay
Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 28988153] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay
|
[PMID: 29043798] |
| L6 | IC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue staining-based fluorometric analysis
Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue staining-based fluorometric analysis
|
[PMID: 29172086] |
| L6 | IC50 |
0.007 μg/mL
Compound: POD
|
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay
|
[PMID: 29220797] |
| L6 | IC50 |
0.007 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay
|
[PMID: 29244495] |
| L6 | IC50 |
0.041 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
[PMID: 29560715] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
|
[PMID: 29896963] |
| L6 | CC50 |
0.007 μM
Compound: PPT
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay
|
[PMID: 30006174] |
| L6 | IC50 |
0.01 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue staining-based fluorometric analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue staining-based fluorometric analysis
|
[PMID: 30302998] |
| L6 | IC50 |
0.009 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 30565934] |
| L6 | CC50 |
0.007 μM
Compound: PPT
|
Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis
Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis
|
[PMID: 30615444] |
| L6 | IC50 |
0.005 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 30916554] |
| L6 | IC50 |
0.012 μM
Compound: POD
|
Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
|
[PMID: 30962114] |
| L6 | IC50 |
0.018 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay
|
[PMID: 30975502] |
| L6 | IC50 |
0.005 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability
Cytotoxicity against rat L6 cells assessed as reduction in cell viability
|
[PMID: 31515186] |
| L6 | IC50 |
0.018 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay
|
[PMID: 31550659] |
| L6 | IC50 |
0.041 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue staining-based fluorometric analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue staining-based fluorometric analysis
|
[PMID: 31630523] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue dye-based fluorometric analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue dye-based fluorometric analysis
|
[PMID: 31642313] |
| L6 | IC50 |
0.012 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis
|
[PMID: 31784198] |
| L6 | IC50 |
0.007 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorimetry analysis
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorimetry analysis
|
[PMID: 31799840] |
| L6 | EC50 |
0.014 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells incubated for 70 hrs by resazurin dye based assay
Cytotoxicity against rat L6 cells incubated for 70 hrs by resazurin dye based assay
|
[PMID: 32134269] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin staining based inverted microscopic analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin staining based inverted microscopic analysis
|
[PMID: 32745819] |
| L6 | IC50 |
0.024 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 33002847] |
| L6 | CC50 |
0.019 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 70 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 70 hrs by Alamar blue assay
|
[PMID: 33070078] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by resazurin dye based inverted microscopic analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by resazurin dye based inverted microscopic analysis
|
[PMID: 33095014] |
| L6 | IC50 |
0.012 μM
Compound: pod
|
Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay
|
[PMID: 33148495] |
| L6 | IC50 |
0.0145 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay
|
[PMID: 33524940] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorometric analysis
Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorometric analysis
|
[PMID: 33843232] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 70 hrs by resazurin dye based assay
Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 70 hrs by resazurin dye based assay
|
[PMID: 33901399] |
| L6 | IC50 |
0.006 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay
|
[PMID: 34091216] |
| L6 | IC50 |
11 nM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue dye-based fluorometric analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue dye-based fluorometric analysis
|
[PMID: 34095848] |
| L6 | IC50 |
0.017 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells assessed as reduction in cell viability by resazurin dye based assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability by resazurin dye based assay
|
[PMID: 36972793] |
| L6 | IC50 |
0.005 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells incubated for 72 hrs by Resazurin-dye based assay
Cytotoxicity against rat L6 cells incubated for 72 hrs by Resazurin-dye based assay
|
[PMID: 37942619] |
| L6 | EC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 38823730] |
| L6 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
10.1039/C2MD20136D |
| L6 | IC50 |
0.022 μM
Compound: Podophyllotoxin
|
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
|
10.1039/C4MD00406J |
| L6 | IC50 |
0.02 μM
Compound: Podo
|
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
|
10.1039/C5MD00498E |
| L929 | IC50 |
1.37 μM
Compound: 1
|
Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| LNCaP | IC50 |
0.031 μM
Compound: 2
|
Cytotoxicity against androgen sensitive human LNCaP cells
Cytotoxicity against androgen sensitive human LNCaP cells
|
[PMID: 17256902] |
| LNCaP | ED50 |
0.04 μg/mL
Compound: 12
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 8277312] |
| LOX IMVI | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human LOXIMVI cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human LOXIMVI cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Lu1 | ED50 |
0.008 μg/mL
Compound: 12
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 8277312] |
| M14 | GI50 |
0.07 μM
Compound: 1
|
In vitro cytotoxic activity against melanoma (M 14) cancer cell line.
In vitro cytotoxic activity against melanoma (M 14) cancer cell line.
|
[PMID: 10465531] |
| M14 | GI50 |
13.1 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human M14 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human M14 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Malme-3M | GI50 |
47315.1 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human MALME-3M cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human MALME-3M cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| MCF-10A | IC50 |
16.58 μM
Compound: PPT
|
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| MCF7 | IC50 |
15 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human MCF7 cells after 72 hrs
Antiproliferative activity against human MCF7 cells after 72 hrs
|
[PMID: 17034133] |
| MCF7 | IC50 |
15 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
|
[PMID: 17197178] |
| MCF7 | IC50 |
15 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
|
[PMID: 17482458] |
| MCF7 | IC50 |
0.015 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
|
[PMID: 17977727] |
| MCF7 | IC50 |
8.5 μM
Compound: podophyllotoxin
|
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
|
[PMID: 18586491] |
| MCF7 | GI50 |
0.01 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 21615090] |
| MCF7 | IC50 |
1.18 μM
Compound: 1
|
Anticancer activity against human MCF7 cells after 48 hrs by MTT assay
Anticancer activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 22136907] |
| MCF7 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human MCF7 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human MCF7 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| MCF7 | IC50 |
3.5 μM
Compound: PDT, 4
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 22472045] |
| MCF7 | IC50 |
64.99 μM
Compound: PDT
|
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
|
[PMID: 24457094] |
| MCF7 | GI50 |
0.23 μM
Compound: 1
|
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 24953821] |
| MCF7 | IC50 |
0.0001 μM
Compound: 2
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 25084144] |
| MCF7 | IC50 |
0.0004 μM
Compound: 2
|
Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
|
[PMID: 25084144] |
| MCF7 | IC50 |
0.1 nM
Compound: 2
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 25084144] |
| MCF7 | IC50 |
0.4 nM
Compound: 2
|
Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
|
[PMID: 25084144] |
| MCF7 | GI50 |
0.31 μM
Compound: 1
|
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
|
[PMID: 25131956] |
| MCF7 | IC50 |
3.52 μg/mL
Compound: Podophyllotoxin
|
Anticancer activity against human MCF7 cells after 24 hrs by MTT assay
Anticancer activity against human MCF7 cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| MCF7 | IC50 |
3.34 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells assessed as cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell viability by SRB assay
|
[PMID: 26022842] |
| MCF7 | IC50 |
0.017 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
|
[PMID: 26086179] |
| MCF7 | IC50 |
0.23 μM
Compound: 1; PT
|
Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay
Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay
|
[PMID: 26854430] |
| MCF7 | IC50 |
0.01 μM
Compound: PPT
|
Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| MCF7 | IC50 |
1.11 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay
|
[PMID: 27262599] |
| MCF7 | IC50 |
0.02 μM
Compound: Podo
|
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| MCF7 | IC50 |
0.02 μM
Compound: Podophyllotoxin
|
Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 28006904] |
| MCF7 | IC50 |
0.2 μM
Compound: Podophyllotoxin
|
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 28006904] |
| MCF7 | IC50 |
0.3 μM
Compound: Podophyllotoxin
|
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 28006904] |
| MCF7 | IC50 |
7.13 μM
Compound: 1; PPT
|
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
|
[PMID: 28757065] |
| MCF7 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 29289884] |
| MCF7 | IC50 |
4.16 μM
Compound: PDT
|
Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| MCF7 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method
Cytotoxicity against human MCF7 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method
|
[PMID: 29670695] |
| MCF7 | IC50 |
0.028 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 29670695] |
| MCF7 | IC50 |
2.21 μM
Compound: Podo
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 30025350] |
| MCF7 | IC50 |
3.75 μM
Compound: 1; PPT
|
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 30108892] |
| MCF7 | IC50 |
0.28 μM
Compound: PDX
|
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
|
[PMID: 30482548] |
| MCF7 | IC50 |
2.4 μM
Compound: PTOX
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| MCF7 | IC50 |
0.005 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human MCF7 cells measured after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells measured after 72 hrs by sulforhodamine B assay
|
[PMID: 30920216] |
| MCF7 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
|
[PMID: 31546197] |
| MCF7 | IC50 |
10.86 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
|
[PMID: 31884407] |
| MCF7 | IC50 |
64.99 μM
Compound: Podophyllotoxin
|
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
|
[PMID: 32731188] |
| MCF7 | IC50 |
15.8 nM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
|
[PMID: 32992133] |
| MCF7 | IC50 |
2.13 μM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay
|
[PMID: 32992133] |
| MCF7 | IC50 |
>200000 nM
Compound: PPT
|
Cytotoxicity in human MCF7 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
Cytotoxicity in human MCF7 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
|
[PMID: 34098082] |
| MCF7 | IC50 |
0.039 μM
Compound: PPT
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 35447432] |
| MCF7 | IC50 |
10.04 μM
Compound: PDT
|
Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
|
[PMID: 37146520] |
| MCF7 | IC50 |
16.67 μM
Compound: PPT
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| MCF7 | IC50 |
2.4 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
|
[PMID: 38107170] |
| MCF7 | ED50 |
1.1 x 10-6 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
|
[PMID: 7714533] |
| MCF7 | GI50 |
0.6 μM
Compound: 1
|
In vitro cytotoxicity against human breast cancer MCF-7 ADR cell line
In vitro cytotoxicity against human breast cancer MCF-7 ADR cell line
|
[PMID: 9871772] |
| MCF7 | GI50 |
0.9 μM
Compound: 1
|
In vitro cytotoxicity against human breast cancer MCF-7 cell line
In vitro cytotoxicity against human breast cancer MCF-7 cell line
|
[PMID: 9871772] |
| MDA-MB-231 | IC50 |
0.008 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay
Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay
|
[PMID: 16213720] |
| MDA-MB-231 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| MDA-MB-231 | IC50 |
35.7 μM
Compound: PDT
|
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
|
[PMID: 24457094] |
| MDA-MB-231 | IC50 |
0.079 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
|
[PMID: 26086179] |
| MDA-MB-231 | IC50 |
0.12 μM
Compound: PPT
|
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| MDA-MB-231 | IC50 |
9.76 μM
Compound: IV
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 29289881] |
| MDA-MB-231 | IC50 |
5.73 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
|
[PMID: 31884407] |
| MDA-MB-231 | IC50 |
0.017 μM
Compound: PPT
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 35447432] |
| MDA-MB-231 | IC50 |
20.22 μM
Compound: PDT
|
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
|
[PMID: 37146520] |
| MDA-MB-231 | IC50 |
9.49 μM
Compound: PPT
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| MDA-MB-231 | IC50 |
80.48 nM
Compound: Podo
|
Antiproliferation activity against human MDA-MB-231 cells measured after 72 hrs incubation by MTT assay
Antiproliferation activity against human MDA-MB-231 cells measured after 72 hrs incubation by MTT assay
|
[PMID: 38781920] |
| MDA-MB-231 | IC50 |
0.026 μM
Compound: Podophyllotoxin
|
Inhibition of the growth of MDA-MB 231 human breast cancer cells
Inhibition of the growth of MDA-MB 231 human breast cancer cells
|
[PMID: 9357519] |
| MDA-MB-231 | GI50 |
0.04 μM
Compound: 1
|
In vitro cytotoxicity against human breast cancer MDA-MB 231 cell line
In vitro cytotoxicity against human breast cancer MDA-MB 231 cell line
|
[PMID: 9871772] |
| MDA-MB-231 | IC50 |
<0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay
|
10.1039/C0MD00263A |
| MDA-MB-435 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| MDA-MB-435 | GI50 |
0.7 μM
Compound: 1
|
In vitro cytotoxicity against human breast cancer MDA-MB 435 cell line
In vitro cytotoxicity against human breast cancer MDA-MB 435 cell line
|
[PMID: 9871772] |
| MDA-MB-468 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human MDA-MB-468 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human MDA-MB-468 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| MDA-N | GI50 |
0.07 μM
Compound: 1
|
In vitro cytotoxicity against human breast cancer MDA-N cell line
In vitro cytotoxicity against human breast cancer MDA-N cell line
|
[PMID: 9871772] |
| MG-63 | IC50 |
0.007 μM
Compound: 1
|
Cytotoxicity against human MG63 cells after 72 hrs by MTT assay
Cytotoxicity against human MG63 cells after 72 hrs by MTT assay
|
[PMID: 29670695] |
| MG-63 | IC50 |
18.3 μM
Compound: 1
|
Cytotoxicity against human MG63 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method
Cytotoxicity against human MG63 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method
|
[PMID: 29670695] |
| MIA PaCa-2 | GI50 |
0.51 μM
Compound: 1
|
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay
|
[PMID: 25131956] |
| MIA PaCa-2 | IC50 |
0.012 μM
Compound: Podo
|
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| MIA PaCa-2 | IC50 |
19.67 nM
Compound: Podo
|
Antiproliferation activity against human MIA PaCa-2 cells measured after 72 hrs incubation by MTT assay
Antiproliferation activity against human MIA PaCa-2 cells measured after 72 hrs incubation by MTT assay
|
[PMID: 38781920] |
| MOLT-3 | IC50 |
14 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human Molt3 cells after 72 hrs
Antiproliferative activity against human Molt3 cells after 72 hrs
|
[PMID: 17034133] |
| MOLT-3 | IC50 |
14 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human Molt3 cells
Antiproliferative activity against human Molt3 cells
|
[PMID: 17197178] |
| MOLT-3 | IC50 |
14 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human Molt3 cells
Antiproliferative activity against human Molt3 cells
|
[PMID: 17482458] |
| MOLT-3 | IC50 |
0.014 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human Molt3 cells
Antiproliferative activity against human Molt3 cells
|
[PMID: 17977727] |
| MOLT-4 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human MOLT4 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human MOLT4 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| MRC5 | IC50 |
10.6 μM
Compound: PTOX
|
Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 30878833] |
| NCI/ADR-RES | GI50 |
0.6 μM
Compound: 1
|
In vitro cytotoxic activity against ADR resistant breast cancer (MCF-7-ADR) cell line.
In vitro cytotoxic activity against ADR resistant breast cancer (MCF-7-ADR) cell line.
|
[PMID: 10465531] |
| NCI/ADR-RES | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| NCI-H1299 | IC50 |
1.33 μM
Compound: PPT
|
Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| NCI-H1975 | IC50 |
12.56 μM
Compound: PPT
|
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
|
[PMID: 37395092] |
| NCI-H226 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human NCI-H226 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human NCI-H226 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| NCI-H23 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human NCI-H23 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human NCI-H23 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| NCI-H322M | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human NCI-H322M cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human NCI-H322M cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| NCI-H460 | GI50 |
10.6 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human NCI-H460 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| NCI-H460 | IC50 |
24.58 nM
Compound: Podo
|
Antiproliferation activity against human NCI-H460 cells measured after 72 hrs incubation by MTT assay
Antiproliferation activity against human NCI-H460 cells measured after 72 hrs incubation by MTT assay
|
[PMID: 38781920] |
| NCI-H520 | GI50 |
0.7 μM
Compound: 1
|
In vitro cytotoxic activity against lung (H 522) cancer cell line.
In vitro cytotoxic activity against lung (H 522) cancer cell line.
|
[PMID: 10465531] |
| NCI-H522 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human NCI-H522 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human NCI-H522 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| NIH3T3 | IC50 |
0.084 μM
Compound: podophyllotoxin
|
Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
|
[PMID: 26086179] |
| NIH3T3 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against mouse NIH/3T3 cells by MTT assay
Antiproliferative activity against mouse NIH/3T3 cells by MTT assay
|
[PMID: 31546197] |
| OVCAR-3 | IC50 |
0.46 μM
Compound: podophyllotoxin
|
Antitumor activity against human OVCAR-3 cells xenografted in mouse assessed as increase in mouse life span
Antitumor activity against human OVCAR-3 cells xenografted in mouse assessed as increase in mouse life span
|
[PMID: 20187635] |
| OVCAR-3 | GI50 |
11.3 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human OVCAR3 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human OVCAR3 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| OVCAR-4 | GI50 |
17.5 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human OVCAR4 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human OVCAR4 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| OVCAR-8 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human OVCAR8 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human OVCAR8 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| P388 | IC50 |
0.0043 μg/mL
Compound: 1 (podophyllotoxin)
|
Cytotoxicity against P-388 leukemia cells
Cytotoxicity against P-388 leukemia cells
|
[PMID: 10714489] |
| P388 | IC50 |
0.012 μM
Compound: 1
|
Tested in vitro for antineoplastic activity against P-388 (lymphoid neoplasm from DBA/2 mouse) tumor cell line
Tested in vitro for antineoplastic activity against P-388 (lymphoid neoplasm from DBA/2 mouse) tumor cell line
|
[PMID: 14971901] |
| P388 | IC50 |
2900 nM
Compound: 2d
|
In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line
In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line
|
[PMID: 14980682] |
| P388 | IC50 |
0.012 μM
Compound: 1
|
Cytotoxicity against mouse P388 cells after 4 days
Cytotoxicity against mouse P388 cells after 4 days
|
[PMID: 17197187] |
| P388 | IC50 |
0.013 μg/mL
Compound: 2
|
Growth inhibition of P388-D1 (murine leukemia) cell line.
Growth inhibition of P388-D1 (murine leukemia) cell line.
|
[PMID: 2002477] |
| P388 | IC50 |
10.4 nM
Compound: PT
|
Cytotoxicity against mouse P388 cells assessed as cell viability after 48 hrs by trypan blue exclusion assay
Cytotoxicity against mouse P388 cells assessed as cell viability after 48 hrs by trypan blue exclusion assay
|
[PMID: 21916509] |
| P388 | ED50 |
0.0043 μg/mL
Compound: 1a
|
Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay
|
[PMID: 26938998] |
| P388 | IC50 |
5.9 nM
Compound: Podophyllotoxin
|
Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
|
[PMID: 2778449] |
| P388 | IC50 |
10.4 μM
Compound: 185
|
Cytotoxicity against mouse P388 cells measured after 48 hrs by MTT assay
Cytotoxicity against mouse P388 cells measured after 48 hrs by MTT assay
|
[PMID: 35598527] |
| P388 | IC50 |
0.012 μM
Compound: 1
|
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
|
[PMID: 7673931] |
| P388 | ED50 |
0.003 μg/mL
Compound: 12
|
Cytotoxicity in mouse P388 cells
Cytotoxicity in mouse P388 cells
|
[PMID: 8277312] |
| P388 | IC50 |
0.05 μM
Compound: 6 (Podophyllotoxin)
|
Compound was tested for inhibition of cell growth of P-388 cells
Compound was tested for inhibition of cell growth of P-388 cells
|
10.1016/0960-894X(95)00008-H |
| P388 | IC50 |
0.012 μM
Compound: 1 (Podophyllotoxin)
|
Antineoplastic activity against P-388 (murine leukemia) cell line.
Antineoplastic activity against P-388 (murine leukemia) cell line.
|
10.1016/0960-894X(95)00432-S |
| Panel NCI-60 (60 carcinoma cell lines) | GI50 |
10 nM
Compound: Podophyllotoxin
|
Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
|
[PMID: 15743190] |
| PBMC | IC50 |
5.02 μM
Compound: Ref 34, Cpd 1
|
Cytotoxicity against PBMC (unknown origin) incubated for 24 hrs by CCK8 assay
Cytotoxicity against PBMC (unknown origin) incubated for 24 hrs by CCK8 assay
|
[PMID: 32992133] |
| PC-3 | IC50 |
0.013 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay
Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay
|
[PMID: 16213720] |
| PC-3 | IC50 |
12.5 nM
Compound: Podophyllotoxin
|
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
|
[PMID: 16441066] |
| PC-3 | IC50 |
10 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human PC3 cells after 72 hrs
Antiproliferative activity against human PC3 cells after 72 hrs
|
[PMID: 17034133] |
| PC-3 | IC50 |
10 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human PC3 cells
Antiproliferative activity against human PC3 cells
|
[PMID: 17197178] |
| PC-3 | IC50 |
0.034 μM
Compound: 2
|
Cytotoxicity against androgen-independent human PC3 cells
Cytotoxicity against androgen-independent human PC3 cells
|
[PMID: 17256902] |
| PC-3 | IC50 |
10 nM
Compound: podophyllotoxin
|
Antiproliferative activity against human PC3 cells
Antiproliferative activity against human PC3 cells
|
[PMID: 17482458] |
| PC-3 | IC50 |
0.01 μM
Compound: podophyllotoxin
|
Antiproliferative activity against human PC3 cells
Antiproliferative activity against human PC3 cells
|
[PMID: 17977727] |
| PC-3 | IC50 |
18.9 μM
Compound: 1
|
Cytotoxicity against human PC-3 cells by sulforhodamine B assay
Cytotoxicity against human PC-3 cells by sulforhodamine B assay
|
[PMID: 17988764] |
| PC-3 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human PC3 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human PC3 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| PC-3 | IC50 |
0.05 μM
Compound: PPT
|
Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay
Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| PC-3 | IC50 |
0.07 μM
Compound: Podophyllotoxin
|
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
|
[PMID: 28131777] |
| PC-3 | IC50 |
0.07 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
|
[PMID: 28648953] |
| PC-3 | IC50 |
0.07 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
|
[PMID: 29525336] |
| PC-3 | IC50 |
0.12 μM
Compound: PDX
|
Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
|
[PMID: 30482548] |
| PC-3 | IC50 |
0.2 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human PC3 cells measured after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells measured after 72 hrs by sulforhodamine B assay
|
[PMID: 30920216] |
| PC-3 | IC50 |
3.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human PC3 cells by MTT assay
Antiproliferative activity against human PC3 cells by MTT assay
|
[PMID: 31546197] |
| PC-3 | IC50 |
15.8 nM
Compound: Ref 34, Cpd 1
|
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
|
[PMID: 32992133] |
| PC-3 | IC50 |
0.06 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 34175586] |
| PC-3 | ED50 |
1.2 x 10-7 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human PC3 cells by MTT assay
Cytotoxicity against human PC3 cells by MTT assay
|
[PMID: 7714533] |
| PC-3M | IC50 |
234.9 nM
Compound: PPT
|
Cytotoxicity in human PC-3M cells assessed as inhibition of cell proliferation measured by CCK-8 assay
Cytotoxicity in human PC-3M cells assessed as inhibition of cell proliferation measured by CCK-8 assay
|
[PMID: 34098082] |
| Raji | IC50 |
0.018 μM
Compound: B
|
Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
|
[PMID: 20129783] |
| RAW264.7 | IC50 |
61.3 μg/mL
Compound: Podophyllotoxin
|
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 37550948] |
| RKO | IC50 |
>0.5 μM
Compound: podophyllotoxin
|
Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay
Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay
|
[PMID: 16970401] |
| RKO | IC50 |
0.029 μM
Compound: podophyllotoxin
|
Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay
|
[PMID: 16970401] |
| RPMI-8226 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human RPMI8226 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human RPMI8226 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| RXF 393 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human RXF393 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human RXF393 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SF-268 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SF268 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SF268 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SF-295 | IC50 |
5.69 μM
Compound: 1
|
Cytotoxicity against human SF295 cells by sulforhodamine B assay
Cytotoxicity against human SF295 cells by sulforhodamine B assay
|
[PMID: 17988764] |
| SF-295 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SF295 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SF295 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SF-539 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SF539 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SF539 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SGC-7901 | IC50 |
2.95 μM
Compound: 1
|
Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay
Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| SGC-7901 | IC50 |
0.34 μM
Compound: 1
|
Cytotoxicity against human SGC7901 cells after 48 hrs
Cytotoxicity against human SGC7901 cells after 48 hrs
|
[PMID: 23022053] |
| SH-SY5Y | IC50 |
7 nM
Compound: 2, podophyllotoxin
|
Cytotoxicity against SH-SY5Y cells assessed as cell viability after 48 hrs by MTT method
Cytotoxicity against SH-SY5Y cells assessed as cell viability after 48 hrs by MTT method
|
[PMID: 17765552] |
| SH-SY5Y | IC50 |
2.54 μM
Compound: 1
|
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
|
[PMID: 22687745] |
| SH-SY5Y | IC50 |
1.05 μg/mL
Compound: Podophyllotoxin
|
Anticancer activity against human SH-SY5Y cells after 24 hrs by MTT assay
Anticancer activity against human SH-SY5Y cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| SiHa | IC50 |
0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human SiHa cells measured after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SiHa cells measured after 72 hrs by sulforhodamine B assay
|
[PMID: 30920216] |
| SK-MEL-2 | GI50 |
14.9 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SK-MEL-28 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SK-MEL-5 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SK-MEL-5 | ED50 |
4.1 x 10-8 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human SK-MEL-5 cells by MTT assay
Cytotoxicity against human SK-MEL-5 cells by MTT assay
|
[PMID: 7714533] |
| SK-N-SH | IC50 |
7.92 μM
Compound: 1
|
Cytotoxicity against human SK-N-SH cells assessed as cell viability by SRB assay
Cytotoxicity against human SK-N-SH cells assessed as cell viability by SRB assay
|
[PMID: 26022842] |
| SK-N-SH | IC50 |
<0.1 μM
Compound: Podophyllotoxin
|
Cytotoxicity against human SK-N-SH cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SK-N-SH cells assessed as growth inhibition after 48 hrs by SRB assay
|
10.1039/C0MD00263A |
| SK-OV-3 | GI50 |
0.9 μM
Compound: 1
|
In vitro cytotoxic activity against Ovarian (SK-OV3) cell line.
In vitro cytotoxic activity against Ovarian (SK-OV3) cell line.
|
[PMID: 10465531] |
| SK-OV-3 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SKOV3 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SKOV3 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SK-OV-3 | ED50 |
4.2 x 10-5 μg/mL
Compound: podophyllotoxin
|
Cytotoxicity against human SKOV3 cells by MTT assay
Cytotoxicity against human SKOV3 cells by MTT assay
|
[PMID: 7714533] |
| SN12C | GI50 |
17.1 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SN12C cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SN12C cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SNB-19 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SNB19 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SNB19 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SNB-75 | GI50 |
659.2 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SNB75 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SNB75 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SR | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SR cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SR cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| SW-620 | GI50 |
2 μM
Compound: 1
|
In vitro cytotoxic activity against colon (SW 620) cancer cell line.
In vitro cytotoxic activity against colon (SW 620) cancer cell line.
|
[PMID: 10465531] |
| SW-620 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human SW620 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human SW620 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| T47D | GI50 |
84527.9 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human T47D cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human T47D cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| T47D | EC50 |
2.97 nM
Compound: PPT
|
Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay
Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay
|
[PMID: 27187855] |
| T47D | EC50 |
8.98 μM
Compound: PPT
|
Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay
Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay
|
[PMID: 27187855] |
| T47D | IC50 |
0.25 μM
Compound: PPT
|
Antiproliferative activity against human T47D cells after 96 hrs by SRB assay
Antiproliferative activity against human T47D cells after 96 hrs by SRB assay
|
[PMID: 27187855] |
| THP-1 | IC50 |
19.55 μM
Compound: Podophyllotoxin
|
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
|
[PMID: 31884407] |
| TK-10 | GI50 |
30.5 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human TK10 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human TK10 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| U-251 | GI50 |
10.7 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human U251 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human U251 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| U-373MG ATCC | ED50 |
0.004 μg/mL
Compound: 12
|
Cytotoxicity against human U373 cells
Cytotoxicity against human U373 cells
|
[PMID: 8277312] |
| UACC-257 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human UACC257 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human UACC257 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| UACC-62 | GI50 |
10 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human UACC62 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human UACC62 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| UO-31 | GI50 |
16.6 nM
Compound: PT, NSC 24818
|
Cytotoxicity against human UO31 cells after 48 hrs by trypan blue dye exclusion assay
Cytotoxicity against human UO31 cells after 48 hrs by trypan blue dye exclusion assay
|
[PMID: 22370267] |
| Vero | IC50 |
0.016 μM
Compound: podophyllotoxin
|
Toxicity against monkey Vero cells
Toxicity against monkey Vero cells
|
[PMID: 17618122] |
| Vero | IC50 |
0.023 μM
Compound: podophyllotoxin
|
Cytotoxicity against african green monkey Vero cells after 3 days by tetrazolium dye based colorimetric assay
Cytotoxicity against african green monkey Vero cells after 3 days by tetrazolium dye based colorimetric assay
|
[PMID: 19058972] |
| Vero | IC50 |
1.78 μM
Compound: 1
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 22687745] |
| Vero | IC50 |
17 nM
Compound: Podo
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Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
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[PMID: 23167812] |
| Vero | CC50 |
5.74 μM
Compound: Podophyllotoxin
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 28763644] |
| Vero | IC50 |
1.04 μM
Compound: Ref 34, Cpd 1
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 32992133] |
| WRL68 | IC50 |
4.8 μM
Compound: podophyllotoxin
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Cytotoxicity against human WRL68 cells after 24 hrs by MTT assay
Cytotoxicity against human WRL68 cells after 24 hrs by MTT assay
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[PMID: 18586491] |
| WRL68 | IC50 |
1.989 μg/mL
Compound: Podophyllotoxin
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Anticancer activity against human WRL68 cells after 24 hrs by MTT assay
Anticancer activity against human WRL68 cells after 24 hrs by MTT assay
|
[PMID: 25305717] |
| WRL68 | IC50 |
3.02 μM
Compound: PDT
|
Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| ZR-75-1 | ED50 |
0.4 μg/mL
Compound: 12
|
Cytotoxicity against human ZR-75-1 cells
Cytotoxicity against human ZR-75-1 cells
|
[PMID: 8277312] |
Podophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 518-28-5
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Appearance Solid
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Molecular Weight 414.41
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Formula C22H22O8
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Color White to off-white
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SMILES
O=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@]21[H]
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Synonyms
Podophyllotoxin
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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ACS Nano
Coassembly Nanomedicine Mediated by Intermolecular Interactions Between Methotrexate and Baricitinib for Improved Rheumatoid Arthritis Treatment. [Abstract]2024 Mar 19;18(11):8337-8349. PMID: 38437640 -
Cancer Immunol Res
Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]2023 May 3;11(5):583-599. PMID: 36921097 -
J Ethnopharmacol
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model. [Abstract]2026 Feb 28:357:120954. PMID: 41285229 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Physiol Res
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation. [Abstract]2025 Apr 30;74(2):287-300. PMID: 40432443 -
Exp Ther Med
Podofilox suppresses gastric cancer cell proliferation by regulating cell cycle arrest and the c-Myc/ATG10 axis. [Abstract]2021 Nov;22(5):1203. PMID: 34584548
Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203. [Abstract]
Cell viability was assessed in AGS and HGC-27 cells following incubation with Podofilox (0-80 nM) for 48 h.
Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203. [Abstract]
The cell cycle was analyzed in AGS and HGC-27 cells following incubation with vehicle or 3.4 nM Podofilox for 48 h.
Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203. [Abstract]
AGS and HGC-27 cells were incubated with vehicle or 3.4 nM Podofilox for 7 days, and cell colony formation was assessed.
Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203. [Abstract]
Western blot analysis of dysregulated genes following treatment with Podofilox.
Solvent & Solubility
DMSO : 100 mg/mL (241.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.02 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.02 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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-
-
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [Content Brief]
[2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31. [Content Brief]
[3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263. [Content Brief]
[4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. [Content Brief]
[5]. Podophyllotoxin
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4131 mL | 12.0653 mL | 24.1307 mL | 60.3267 mL |
| 5 mM | 0.4826 mL | 2.4131 mL | 4.8261 mL | 12.0653 mL | |
| 10 mM | 0.2413 mL | 1.2065 mL | 2.4131 mL | 6.0327 mL | |
| 15 mM | 0.1609 mL | 0.8044 mL | 1.6087 mL | 4.0218 mL | |
| 20 mM | 0.1207 mL | 0.6033 mL | 1.2065 mL | 3.0163 mL | |
| 25 mM | 0.0965 mL | 0.4826 mL | 0.9652 mL | 2.4131 mL | |
| 30 mM | 0.0804 mL | 0.4022 mL | 0.8044 mL | 2.0109 mL | |
| 40 mM | 0.0603 mL | 0.3016 mL | 0.6033 mL | 1.5082 mL | |
| 50 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 1.2065 mL | |
| 60 mM | 0.0402 mL | 0.2011 mL | 0.4022 mL | 1.0054 mL | |
| 80 mM | 0.0302 mL | 0.1508 mL | 0.3016 mL | 0.7541 mL | |
| 100 mM | 0.0241 mL | 0.1207 mL | 0.2413 mL | 0.6033 mL |