GRGDSP
Based on 5 publication(s) in Google Scholar
GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 91037-75-1
- Formula: C22H37N9O10
- Molecular Weight:587.58
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) GRGDSP
More
Customer Validation & Images
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IF
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IF
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WB
Biological Activity
Integrin[1]
It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis[1]. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 91037-75-1
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Appearance Solid
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Molecular Weight 587.58
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Formula C22H37N9O10
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Color White to off-white
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Sequence
Gly-Arg-Gly-Asp-Ser-Pro
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Sequence Shortening
GRGDSP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Theranostics
2022 Oct 17;12(17):7307-7318. PMID: 36438492
GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]
GRGDSP (1 mg/kg; inject at the injured area; single daily for 15 days) apparently reduces the densities of Mpz+, Ki67+and Sox10+ schwann cells in the injured area in the Dhhcre/+;Ninj2fl/fl mice.
GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]
Immunofluorescence staining images of NeuN and ITGB1 in the peri-infarct area. GRGDSP significantly downregulates rOPN-induced ITGB1.
GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]
GRGDSP decreases the expression of ITGB1 in the peri-infarct area.
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Biomed Res Int
2020 Oct 20;2020:2905634. PMID: 33134374 -
Oncol Lett
Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer. [Abstract]2023 Nov 1;26(6):538. PMID: 38020309 -
Am J Transl Res
Osteopontin-integrin signaling positively regulates neuroplasticity through enhancing neural autophagy in the peri-infarct area after ischemic stroke. [Abstract]2022 Nov 15;14(11):7726-7743. PMID: 36505285 -
bioRxiv
2025 Jul 12:2025.07.08.663758. PMID: 40672190
Solvent & Solubility
H2O : 100 mg/mL (170.19 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Qian J, et al. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9. [Content Brief]
[2]. Patel S, et al. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.7019 mL | 8.5095 mL | 17.0190 mL | 42.5474 mL |
| 5 mM | 0.3404 mL | 1.7019 mL | 3.4038 mL | 8.5095 mL | |
| 10 mM | 0.1702 mL | 0.8509 mL | 1.7019 mL | 4.2547 mL | |
| 15 mM | 0.1135 mL | 0.5673 mL | 1.1346 mL | 2.8365 mL | |
| 20 mM | 0.0851 mL | 0.4255 mL | 0.8509 mL | 2.1274 mL | |
| 25 mM | 0.0681 mL | 0.3404 mL | 0.6808 mL | 1.7019 mL | |
| 30 mM | 0.0567 mL | 0.2836 mL | 0.5673 mL | 1.4182 mL | |
| 40 mM | 0.0425 mL | 0.2127 mL | 0.4255 mL | 1.0637 mL | |
| 50 mM | 0.0340 mL | 0.1702 mL | 0.3404 mL | 0.8509 mL | |
| 60 mM | 0.0284 mL | 0.1418 mL | 0.2836 mL | 0.7091 mL | |
| 80 mM | 0.0213 mL | 0.1064 mL | 0.2127 mL | 0.5318 mL | |
| 100 mM | 0.0170 mL | 0.0851 mL | 0.1702 mL | 0.4255 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
GRGDSP Related Classifications
HY-P0290 Related Classifications
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