2. Immunology/Inflammation
  3. COX Interleukin Related
  4. ISP-VT

ISP-VT (Isopropyl vanillate) is a COX-2 inhibitor. ISP-VT exhibits anti-inflammatory, antipyretic and immunomodulatory activities. ISP-VT reduces neutrophil migration and the release of inflammatory factors. ISP-VT can be used for the research of inflammatory and immune diseases and other conditions.

For research use only. We do not sell to patients.

ISP-VT

ISP-VT Chemical Structure

CAS No. : 175796-45-9

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ISP-VT Related Antibodies

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Description

ISP-VT (Isopropyl vanillate) is a COX-2 inhibitor. ISP-VT exhibits anti-inflammatory, antipyretic and immunomodulatory activities. ISP-VT reduces neutrophil migration and the release of inflammatory factors. ISP-VT can be used for the research of inflammatory and immune diseases and other conditions[1][2].

IC50 & Target[2]

COX-2

 

IL-6

 

In Vitro

ISP-VT (compound 4) (300 μM; 20 min) inhibits antigen-induced degranulation in RBL-2H3 cells, with an IC50 of 415 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ISP-VT Related Antibodies
In Vivo

ISP-VT (0.3-3 mg/kg; i.p.; single administration) significantly inhibits carrageenan (HY-125474)-induced paw edema in Swiss mice[2].
ISP-VT (1 mg/kg; i.p.; single administration) exerts anti-inflammatory and antipyretic effects in Swiss mice through selective inhibition of COX-2, reduction of neutrophil migration, and suppression of inflammatory cytokine release[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice treated carrageenan (adult, both sexes, 25-30 g)[2]
Dosage: 0.3 mg/kg; 1 mg/kg; 3 mg/kg
Administration: i.p.; single dose
Result: Reduced paw edema by 53.5% at the 3-hour peak (1 mg/kg dose).
Reduced paw edema by 59.8% at the 3-hour peak (3 mg/kg dose).
Did not significantly reduce edema (0.3 mg/kg dose).
Animal Model: Swiss mice (both sexes, 25-30 g) with carrageenan-induced paw edema, carrageenan-induced peritonitis, and Brewer’s yeast-induced hyperthermia[2]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced paw edema induced by carrageenan, dextran sulfate, compound 48/80, histamine, serotonin, bradykinin, and PGE2.
Decreased leukocyte and neutrophil recruitment, rolling, adhesion, and myeloperoxidase (MPO) activity.
Lowered TNF-α and IL-6 levels and vascular permeability, and downregulated COX-2 expression and selectively inhibited COX-2 activity.
Alleviated gastric toxicity compared with Indomethacin (HY-14397) and reduced rectal temperature in yeast-induced hyperthermic mice.
Molecular Weight

210.23

Formula

C11H14O4
CAS No.
SMILES

O=C(C1=CC=C(C(OC)=C1)O)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ISP-VT Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISP-VT175796-45-9Isopropyl vanillateCOXInterleukin RelatedCyclooxygenaseILimmediate hypersensitivity (type i) allergyCOX-2RBL-2H3 cellstumor necrosis factor-αinterleukin-6Swiss micemyeloperoxidaseneutrophilmouse subplantar tissuecyclooxygenase-2Inhibitorinhibitorinhibit

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