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UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

Also Known as UBC4/5; UBCH5C; E2(17)KB3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7323

About UBE2D3

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,794,383-102,868,895 (from NCBI)

This gene has 33 transcripts (splice variants), 258 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]

UBE2D3 Products (10)

mRNA	Protein	Name
NM_001300795.2	NP_001287724.1	ubiquitin-conjugating enzyme E2 D3 isoform 4
NM_003340.6	NP_003331.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181886.3	NP_871615.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181887.3	NP_871616.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181888.3	NP_871617.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181889.2	NP_871618.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181890.3	NP_871619.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181891.3	NP_871620.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181892.4	NP_871621.1	ubiquitin-conjugating enzyme E2 D3 isoform 2
NM_181893.3	NP_871622.1	ubiquitin-conjugating enzyme E2 D3 isoform 3

UBE2D3 Protein Structure

UQ_con

0
100
147 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 D3	(E3-independent) E2 ubiquitin-conjugating enzyme D3

UBE2D3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2D3	P61077	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	UBE2D3	P61077	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32296183
Intra	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Y2H Array	32296183
Intra	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Y2H Prey Pooling	25416956
Intra	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	22124327
Cross	UBE2D3	P61077	sspH2	Salmonella typhimurium	P0CE12	NMR	20133640
Cross	UBE2D3	P61077	sspH2	Salmonella typhimurium	P0CE12	Ubiquitinase Assay	20133640
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	RNF111	Homo sapiens	Q6ZNA4	Y2H Array	19690564
Intra	UBE2D3	P61077	RNF111	Homo sapiens	Q6ZNA4	Validated Y2H	25416956
Intra	UBE2D3	P61077	RNF25	Homo sapiens	Q96BH1	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	RNF25	Homo sapiens	Q96BH1	Validated Y2H	32296183
Intra	UBE2D3	P61077	RNF25	Homo sapiens	Q96BH1	Y2H Array	32296183
Intra	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Validated Y2H	32296183
Intra	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	32296183
Intra	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	25416956
Intra	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	19690564
Intra	UBE2D3	P61077	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	19549727
Intra	UBE2D3	P61077	ZNRF1	Homo sapiens	Q8ND25	Y2H	19549727
Intra	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Y2H Array	19549727
Intra	UBE2D3	P61077	MID1	Homo sapiens	O15344	Validated Y2H	25416956
Intra	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Prey Pooling	25416956
Intra	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Array	31515488
Intra	UBE2D3	P61077	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	UBE2D3	P61077	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H Array	31515488
Intra	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H Array	19549727
Intra	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H	19549727
Intra	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H Pooling	16189514
Intra	UBE2D3	P61077	RNF11	Homo sapiens	Q9Y3C5	Enzymatic Study	19549727
Intra	UBE2D3	P61077	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	19549727
Intra	UBE2D3	P61077	XIAP	Homo sapiens	P98170	Enzymatic Study	19549727
Intra	UBE2D3	P61077	XIAP	Homo sapiens	P98170	Y2H Array	19549727
Intra	UBE2D3	P61077	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	UBE2D3	P61077	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	UBE2D3	P61077	RNF2	Homo sapiens	Q99496	Y2H Array	32296183
Intra	UBE2D3	P61077	RNF2	Homo sapiens	Q99496	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	RNF2	Homo sapiens	Q99496	Validated Y2H	32296183
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Validated Y2H	25416956
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Pooling	16189514
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	19549727
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	31515488
Intra	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
Intra	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
Intra	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	UBE2D3	P61077	UBTD1	Homo sapiens	Q9HAC8	Y2H Array	32296183
Intra	UBE2D3	P61077	UBTD1	Homo sapiens	Q9HAC8	Y2H Prey Pooling	32296183
Intra	UBE2D3	P61077	UBTD1	Homo sapiens	Q9HAC8	Validated Y2H	32296183
Cross	UBE2D3	P61077	Dapk3	Mus musculus	O54784	Anti Tag CoIP	18515077

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2D3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70998	UBE2D3 Protein, Human	AAH66917 (M1-M147)	≥ 95%, as determined by reducing SDS-PAGE.

UBE2D3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82588	UBE2D3 Antibody (YA2333)	WB, IP	Human, Mouse, Rat
HY-P82588A	UBE2D3 Antibody (YA2333)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0753	Eupalinolide B		99.48%	Unkown
HY-RS15341	UBE2D3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19825	Ube2d3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26321	Ube2d3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2D3	RGD	RGD:619912
Mus musculus	UBE2D3	MGD	MGI:1913355
Felis catus	UBE2D3	VGNC	VGNC:80097
Bos taurus	UBE2D3	VGNC	VGNC:107251
Macaca mulatta	UBE2D3	VGNC	VGNC:82265
Others	UBE2D3	NCBI