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Licochalcone B

12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

For research use only. We do not sell to patients.

  • Purity: 99.91%
  • CAS No.: 58749-23-8
  • Formula: C16H14O5
  • Molecular Weight:286.28
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Licochalcone B Chemical Structure
    Licochalcone B Chemical Structure
  • Experimental Validation Results for Licochalcone B
  • Experimental Validation Results for Licochalcone B
  • Experimental Validation Results for Licochalcone B
  • Experimental Validation Results for Licochalcone B
  • Experimental Validation Results for Licochalcone B
  • Experimental Validation Results for Licochalcone B
CAS No.: 58749-23-8
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  • Licochalcone B Chemical Structure
    Licochalcone B Chemical Structure
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  • 1/16

    Licochalcone B purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 22:150:157584. [Abstract]

    Customer Validation
     Pronase E (1:2000-1000; 30 min) and Licochalcone B (20 μM; 30 min). The NCAM1 protein expression of drug affinity responsive target stability assay (upper panel) and statistical analysis (lower panel). Ns, not significant. **, P <0.01; ***, P <0.001; ****, P <0.0001.

  • 1/16

    Licochalcone B purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2022 Feb 3;23(2):e53499. [Abstract]

    Customer Validation
     Cell Counting Kit 8 (CCK‐8) was used to assess the viability of BMDMs treated with different doses of Licochalcone B (LicoB) (10, 20, 30, 40, 50, 60, 70, 80 μM) for 24 h.

  • 1/16

    Licochalcone B purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2022 Feb 3;23(2):e53499. [Abstract]

    Customer Validation
     Western blot analysis of cross-linked ASC in the Triton X-insoluble pellet from LPS-primed BMDMs pre-treated with Licochalcone B (LicoB) (20 μM) or vehicle and then stimulated with nigericin, poly(dA:dT) or Salmonella.

  • 1/16

    Licochalcone B purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2022 Feb 3;23(2):e53499. [Abstract]

    Customer Validation
     TNF-α production in the supernatant (SN) was measured using ELISA treated with Licochalcone B (LicoB) (5, 10, 20, 40 μM) for 1 h (LicoB after LPS).

  • 1/16

    Licochalcone B purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2022 Feb 3;23(2):e53499. [Abstract]

    Customer Validation
     Representative liver section images stained with H&E, Sirius Red and Masson’s trichrome stains treated with Licochalcone B (LicoB) (40 mg/kg, i.g.), MCC950 or a combination of LicoB and MCC950.

  • 1/16

    Licochalcone B purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2022 Feb 3;23(2):e53499. [Abstract]

    Customer Validation
     Real-time quantitative PCR was used to detect the mRNA levels of Col1a1 treated with Licochalcone B (LicoB) (40 mg/kg, i.g.), MCC950 or a combination of LicoB and MCC950.

  • Licochalcone B