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Cat. No.: HY-190554

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STK436742

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research.

For research use only. We do not sell to patients.

CAS No.: 610266-79-0
Formula: C₁₈H₁₄N₂O₃
Molecular Weight:306.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STK436742 Chemical Structure

CAS No.: 610266-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

All TRP Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	4.35 μM	Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation. Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation.	42732743
HEK293	IC50	0.69 μM	Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application. Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application.	42732743

In Vitro

STK436742 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium influx in TRPV1-expressing HEK293 cells with an FDSS IC₅₀ of 4.35 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 610266-79-0
Molecular Weight 306.32
Formula C₁₈H₁₄N₂O₃
SMILES

OC1=C2C(C=CC=C2)=CC=C1C(N/N=C/C3=CC=CC(O)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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