Cat. No.: HY-161015

JAK1-IN-13

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC₅₀ of 0.044 nM. JAK1-IN-13 significantly decreases STAT3 phosphorylation.

For research use only. We do not sell to patients.

Purity: 98.65%
CAS No.: 2778330-90-6
Formula: C₂₃H₂₆F₃N₅O
Molecular Weight:445.48

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

JAK1-IN-13 Chemical Structure

CAS No.: 2778330-90-6

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC₅₀ of 0.044 nM. JAK1-IN-13 significantly decreases STAT3 phosphorylation^[1].

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	0.001 μM Compound: 36b	Growth inhibition of mouse BaF3 cells harboring JAK1 measured after 72 hrs by CCK-8 assay Growth inhibition of mouse BaF3 cells harboring JAK1 measured after 72 hrs by CCK-8 assay	[PMID: 38031930]
BaF3	GI₅₀	0.174 μM Compound: 36b	Growth inhibition of mouse BaF3 cells harboring TYK2 measured after 72 hrs by CCK-8 assay Growth inhibition of mouse BaF3 cells harboring TYK2 measured after 72 hrs by CCK-8 assay	[PMID: 38031930]
BaF3	GI₅₀	0.577 μM Compound: 36b	Growth inhibition of mouse BaF3 cells harboring JAK2 measured after 72 hrs by CCK-8 assay Growth inhibition of mouse BaF3 cells harboring JAK2 measured after 72 hrs by CCK-8 assay	[PMID: 38031930]
BaF3	GI₅₀	1.41 μM Compound: 36b	Growth inhibition of mouse BaF3 cells harboring JAK3 measured after 72 hrs by CCK-8 assay Growth inhibition of mouse BaF3 cells harboring JAK3 measured after 72 hrs by CCK-8 assay	[PMID: 38031930]
L132	IC₅₀	60 μM Compound: 36b	Cytotoxicity against human L132 cells assessed as inhibition of cell growth measured after 24 hrs by MTT colorimetric assay Cytotoxicity against human L132 cells assessed as inhibition of cell growth measured after 24 hrs by MTT colorimetric assay	[PMID: 38031930]

Chemical Information

CAS No. 2778330-90-6
Appearance Solid
Molecular Weight 445.48
Formula C₂₃H₂₆F₃N₅O
Color White to off-white
SMILES

O=C(C1=C(N[C@@H]2C[C@@H](N(CC2)CC3=CC=C(C=C3)C(F)(F)F)C)C4=C(NC=C4)N=C1)NC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Phytother Res

(+)-Matairesinol, Derived From Olive Oil, Enhanced T-Cell Anti-Tumor Immune via JAK3-STAT1 Signal and Synergized With Anti-PD-1 Efficacy. [Abstract]

2026 Apr 27. PMID: 42037203
J Ethnopharmacol

"Shihu" promote T-cell immunity against breast cancer through bioactive constituent THMB enhancing JAK3-STAT1 signal. [Abstract]

2026 Oct 28:369:121888. PMID: 42202911

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (224.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2448 mL

11.2238 mL

22.4477 mL

5 mM

0.4490 mL

2.2448 mL

4.4895 mL

10 mM

0.2245 mL

1.1224 mL

2.2448 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park E, et al. Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis. J Med Chem. 2023 Dec 14;66(23):16342-16363. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2448 mL	11.2238 mL	22.4477 mL	56.1192 mL
	5 mM	0.4490 mL	2.2448 mL	4.4895 mL	11.2238 mL
	10 mM	0.2245 mL	1.1224 mL	2.2448 mL	5.6119 mL
	15 mM	0.1497 mL	0.7483 mL	1.4965 mL	3.7413 mL
	20 mM	0.1122 mL	0.5612 mL	1.1224 mL	2.8060 mL
	25 mM	0.0898 mL	0.4490 mL	0.8979 mL	2.2448 mL
	30 mM	0.0748 mL	0.3741 mL	0.7483 mL	1.8706 mL
	40 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.4030 mL
	50 mM	0.0449 mL	0.2245 mL	0.4490 mL	1.1224 mL
	60 mM	0.0374 mL	0.1871 mL	0.3741 mL	0.9353 mL
	80 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.7015 mL
	100 mM	0.0224 mL	0.1122 mL	0.2245 mL	0.5612 mL

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JAK1-IN-13

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Anti-Liver Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) JAK1-IN-13

All JAK Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

JAK1-IN-13

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Anti-Liver Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) JAK1-IN-13

All JAK Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

JAK1-IN-13 Related Classifications

HY-161015 Related Classifications