Octopamine
Based on 5 publication(s) in Google Scholar
Octopamine ((±)-p-Octopamine) is an orally active neurotransmitter and neuromodulator that can cross the blood-brain barrier. Octopamine activates octopamine receptors (octopamine receptor), G protein-coupled/Gαs-coupled receptors (G protein-coupled/Gαs-coupled receptor), adenylyl cyclase (adenylyl cyclase)/cAMP, calcium, and hyperpolarizing conductance increases. Octopamine can be used in research on various neurological diseases, metabolic diseases, and cardiovascular and cerebrovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 104-14-3
- Formula: C8H11NO2
- Molecular Weight:153.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Octopamine
MoreAll Endogenous Metabolite Isoforms
MoreAll Calcium Channel Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HEK293 | EC50 |
24 nM
Compound: octopamine
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Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay
Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay
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[PMID: 18033297] |
| Vero E6 | IC50 |
>2.0 × 105 M
Compound: COVC-0677843195
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
In Vitro
Octopamine activates sensitizing receptors and elevates cyclic adenosine monophosphate in the nervous system of Aplysia californica[1].
Octopamine increases cyclic adenosine monophosphate, elicits light flashing, and inhibits muscle contraction in insect tissues, including cockroach nerve cord, firefly lantern, and locust/grasshopper muscle[1].
Octopamine (0.01 M) increases pyruvate concentration in isolated honeybee dorsolongitudinal flight muscle, indicating enhanced glycolysis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:worker bees (female; forager and nurse bees)[2]
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Dosage:0.01 M
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Administration:injection into flight muscles; single administration; 120 min at 34 °C
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Result:Reversed reserpine-induced hypothermia.
No difference from controls was observable.
Increased flight muscle cAMP.
Increased AmGAPDH expression.
Chemical Information
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CAS No. 104-14-3
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Appearance Solid
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Molecular Weight 153.18
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Formula C8H11NO2
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Color White to off-white
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SMILES
OC(C1=CC=C(O)C=C1)CN
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Synonyms
(±)-p-Octopamine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Res
Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism. [Abstract]2026 Apr;36(4):286-299. PMID: 41764323 -
Nat Commun
2025 Dec 18;16(1):11196. PMID: 41413037 -
Insect Mol Biol
2022 Oct;31(5):647-658. PMID: 35652818 -
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Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Axelrod J, et al. Octopamine. Nature. 1977 Feb 10;265(5594):501-4. [Content Brief]
[2]. Kaya-Zeeb S, et al. Octopamine drives honeybee thermogenesis. eLife. 2022 Mar 15;11:e74334.
[3]. Farooqui T, et al. Octopamine-mediated neuromodulation of insect senses. Neurochemical research. 2007 Sep;32(9):1511-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Octopamine Related Classifications
HY-B0528 Related Classifications
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Keywords
- Octopamine
- 104-14-3
- (±)-p-Octopamine
- Endogenous Metabolite
- G Protein-coupled Receptor Kinase (GRK)
- Adenylate Cyclase
- Calcium Channel
- G protein-coupled receptors
- adenylyl cyclase
- blood-brain barrier
- cAMP
- calcium
- monoamine oxidase
- neuromodulator
- neurotransmitter
- octopamine
- octopamine receptors
- Inhibitor
- inhibitor
- inhibit