BMS-243117
BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck.
For research use only. We do not sell to patients.
- CAS No.: 225521-80-2
- Formula: C20H21ClN4O2S
- Molecular Weight:416.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
Lck 4 nM (IC50) |
Fyn 32 nM (IC50) |
Blk 84 nM (IC50) |
Src 158 nM (IC50) |
Hck 960 nM (IC50) |
Lyn 330 nM (IC50) |
Fgr 60 nM (IC50) |
Chemical Information
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CAS No. 225521-80-2
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Molecular Weight 416.92
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Formula C20H21ClN4O2S
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SMILES
O=C(C1=CC=C2N=C(NC(NC(C)(C)C)=O)SC2=C1)NC3=C(C)C=CC=C3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-243117 Related Classifications
HY-120622 Related Classifications
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