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Cat. No.: HY-137005

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CS1

CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis.

For research use only. We do not sell to patients.

CAS No.: 1448009-94-6
Formula: C₁₆H₁₂O₃
Molecular Weight:252.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CS1 Chemical Structure

CAS No.: 1448009-94-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

topoisomerase II alpha

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.5 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 25240702]
HeLa	IC₅₀	4.6 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay	[PMID: 25240702]
MDA-MB-231	IC₅₀	4.3 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay	[PMID: 25240702]
MDA-MB-231	IC₅₀	4.3 μM Compound: CS1	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by CCK8 assay	[PMID: 36063665]

In Vitro

CS1 shows cytotoxicity with IC₅₀ values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively^[1]
. CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)^[1].
CS1 (0-20 µM) shows antiproliferation activity in cancer cells^[1].
CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase^[1].
CS1 (2.5, 5, 10 µM) induces cell apoptosis^[1].
CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

2.5, 5, 10 µM
Incubation Time:
Result:

Cells were arrest at the G2/M phase.

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

2.5, 5, 10 µM
Incubation Time:
Result:

Induced apoptosis

In Vivo

CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Five-week-old female athymic nude mice (BALB/c-nu)^[1]
Dosage:

20 mg/kg
Administration:

i.v., every other day for two weeks
Result:

Showed antitumor effects.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1448009-94-6
Molecular Weight 252.26
Formula C₁₆H₁₂O₃
SMILES

OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shen Y, et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014; 453(3):302-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References

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CS1

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CS1 Related Classifications

HY-137005 Related Classifications