GAK - cyclin G associated kinase Gene

Also Known as DNAJ26; DNAJC26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2580

About GAK

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:849,277-932,316 (from NCBI)

This gene has 22 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.1), colon (RPKM 15.2) and 25 other tissues.

Summary

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GAK Products (49)

mRNA Protein Name
XM_047450020.1 XP_047305976.1 cyclin-G-associated kinase isoform X29
XM_047450016.1 XP_047305972.1 cyclin-G-associated kinase isoform X25
XM_017007994.2 XP_016863483.1 cyclin-G-associated kinase isoform X30
XM_047450035.1 XP_047305991.1 cyclin-G-associated kinase isoform X43
XM_047450004.1 XP_047305960.1 cyclin-G-associated kinase isoform X12
XM_011513427.3 XP_011511729.1 cyclin-G-associated kinase isoform X3
XM_047450010.1 XP_047305966.1 cyclin-G-associated kinase isoform X18
XM_011513429.3 XP_011511731.1 cyclin-G-associated kinase isoform X6
XM_011513425.3 XP_011511727.1 cyclin-G-associated kinase isoform X1
XM_047450028.1 XP_047305984.1 cyclin-G-associated kinase isoform X37
XM_047450030.1 XP_047305986.1 cyclin-G-associated kinase isoform X39
XM_047450026.1 XP_047305982.1 cyclin-G-associated kinase isoform X36
XM_047450021.1 XP_047305977.1 cyclin-G-associated kinase isoform X31
XM_047450007.1 XP_047305963.1 cyclin-G-associated kinase isoform X15
XM_047450005.1 XP_047305961.1 cyclin-G-associated kinase isoform X13
XM_047450034.1 XP_047305990.1 cyclin-G-associated kinase isoform X42
XM_011513430.2 XP_011511732.1 cyclin-G-associated kinase isoform X8
XM_011513434.3 XP_011511736.1 cyclin-G-associated kinase isoform X26
NM_005255.4 NP_005246.2 cyclin-G-associated kinase isoform 1
XM_005272268.3 XP_005272325.1 cyclin-G-associated kinase isoform X5
XM_011513426.3 XP_011511728.1 cyclin-G-associated kinase isoform X2
XM_047450012.1 XP_047305968.1 cyclin-G-associated kinase isoform X21
NM_001286833.1
XM_047450014.1 XP_047305970.1 cyclin-G-associated kinase isoform X23
XM_005272270.3 XP_005272327.1 cyclin-G-associated kinase isoform X20
XM_011513431.3 XP_011511733.1 cyclin-G-associated kinase isoform X9
XM_047450011.1 XP_047305967.1 cyclin-G-associated kinase isoform X19
NM_001318134.2 NP_001305063.1 cyclin-G-associated kinase isoform 3
XM_047450029.1 XP_047305985.1 cyclin-G-associated kinase isoform X38
XM_017007991.2 XP_016863480.1 cyclin-G-associated kinase isoform X7
XM_047450033.1 XP_047305989.1 cyclin-G-associated kinase isoform X42
XM_047450008.1 XP_047305964.1 cyclin-G-associated kinase isoform X16
XM_047450031.1 XP_047305987.1 cyclin-G-associated kinase isoform X40
XM_047450003.1 XP_047305959.1 cyclin-G-associated kinase isoform X11
XM_047450015.1 XP_047305971.1 cyclin-G-associated kinase isoform X24
XM_047450018.1 XP_047305974.1 cyclin-G-associated kinase isoform X27
XM_047450002.1 XP_047305958.1 cyclin-G-associated kinase isoform X10
XM_047450013.1 XP_047305969.1 cyclin-G-associated kinase isoform X22
XM_017007992.2 XP_016863481.1 cyclin-G-associated kinase isoform X17
XM_047450019.1 XP_047305975.1 cyclin-G-associated kinase isoform X28
XM_047450006.1 XP_047305962.1 cyclin-G-associated kinase isoform X14
XM_047450023.1 XP_047305979.1 cyclin-G-associated kinase isoform X33
XM_047450024.1 XP_047305980.1 cyclin-G-associated kinase isoform X34
XM_017007993.2 XP_016863482.1 cyclin-G-associated kinase isoform X26
XM_047450025.1 XP_047305981.1 cyclin-G-associated kinase isoform X35
XM_011513428.3 XP_011511730.1 cyclin-G-associated kinase isoform X4
XM_011513432.3 XP_011511734.1 cyclin-G-associated kinase isoform X11
XM_047450022.1 XP_047305978.1 cyclin-G-associated kinase isoform X32
XM_047450032.1 XP_047305988.1 cyclin-G-associated kinase isoform X41

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22645275 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in Golgi to lysosome transport IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in clathrin coat assembly IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in clathrin coat disassembly IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in intracellular transport IMP
IMP: Inferred from mutant phenotype
18489706 GOA
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
24510904 GOA
involved in protein localization to Golgi apparatus IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
16155256 GOA
involved in regulation of clathrin coat assembly IMP
IMP: Inferred from mutant phenotype
18489706 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16155256 GOA
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
31962345 GOA
located in vesicle IDA
IDA: Inferred from direct assay
24510904 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAK Protein Structure

Pkinase

Pkinase: Protein kinase domain (42 - 312)

PTEN_C2

PTEN_C2: C2 domain of PTEN tumour-suppressor protein (571 - 707)

DnaJ

DnaJ: DnaJ domain (1261 - 1308)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1311 a.a.
Protein Preferred Names Protein Names

cyclin-G-associated kinase

  • auxilin-2

GAK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GAK O14976 HSPA8 Homo sapiens P11142
Anti Tag CoIP
24510904
Intra
GAK O14976 LRRK2 Homo sapiens Q5S007
Protein Array
24947832
Intra
GAK O14976 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
Intra
GAK O14976 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
24510904
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Signet Ring Cell Adenocarcinoma

  • Prostate Signet Ring Cell Carcinoma

  • Signet Ring Cell Carcinoma Of Prostate

  • Acinar Prostate Adenocarcinoma, Signet Ring Variant
Parkinson Disease 15, Autosomal Recessive Early-Onset

  • Parkinsonian-Pyramidal Syndrome

  • Pallidopyramidal Syndrome

  • Parkinson Disease 15, Autosomal Recessive

  • PARK15

  • Pkps

  • Pallido-Pyramidal Syndrome

  • Parkinson'S Disease 15

  • Autosomal Recessive Early-Onset Parkinson Disease 15

  • Autosomal Recessive Early-Onset Parkinson'S Disease 15

  • Pallido-Pyramidal Disease

  • Parkinson Disease 15

  • Parkinson Disease 15 Autosomal Recessive

  • Pps

  • Parkinson Disease, Type 15
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-122186 SGC-GAK-1 99.92% Unkown
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-153385 TMX1 Degrader 99.57% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-171770 dAurAB5 99.03% Unkown
HY-15800A CZC-25146 Inhibitor 98.05% Unkown
HY-169789 PKN3-IN-1 98.97% Unkown
HY-147219A SIAIS164018 hydrochloride 98.06% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-148061 DB1113 99.86% Unkown
HY-155150 JH-XII-03-02 Degrader 99.33% Unkown
HY-124793 GAK inhibitor 49 98.28% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-179717 WZS0347 Degrader 99.06% Unkown
HY-135871 BMT-124110 99.15% Unkown
HY-148063 DB0614 99.92% Unkown
HY-147761 GAK inhibitor 2 Inhibitor 98.58% Unkown
HY-120179A LP-922761 hydrate 98.0% Unkown
HY-124793A GAK inhibitor 49 hydrochloride 99.52% Unkown
HY-135871A BMT-124110 formic Inhibitor / Unkown
HY-147219 SIAIS164018 / Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-101290 BMT-090605 Inhibitor 98.27% Unkown
HY-125142 AP-24567 / Unkown
HY-150782 UNC-CA359 Inhibitor / Unkown
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / Unkown
HY-183098 UNC8209 / Unkown
HY-183100 UNC8461 Control / Unkown
HY-184580 KMG-732 Inhibitor / Unkown
HY-P4443 Ac-GAK-AMC / Unkown
HY-RS05235 GAK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05236 Gak Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05237 Gak Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-174213 AAK1-IN-7 Inhibitor / Unkown
HY-174214 AAK1-IN-8 Inhibitor / Unkown
HY-181169 GAK-IN-3 Inhibitor / Unkown
HY-184096 Forazapadin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GAK VGNC VGNC:41074
Macaca mulatta GAK VGNC VGNC:72865
Mus musculus GAK MGD MGI:2442153
Bos taurus GAK VGNC VGNC:29211
Rattus norvegicus GAK RGD RGD:621589
Felis catus GAK VGNC VGNC:62434
Others GAK NCBI