5-POHSA
5-POHSA is a CD36 and Src kinase modulator acting on taste bud cells, and belongs to the fatty acid esters of hydroxy fatty acids (FAHFA) family. 5-POHSA binds to lingual CD36 to initiate intracellular signaling pathways, activate downstream Src kinase, and rapidly elevate intracellular calcium levels. 5-POHSA interacts with the tongue-brain axis by binding to CD36, so as to ameliorate taste disorders and obesity-related adverse reactions. 5-POHSA is applicable to the research of obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2161370-68-7
- 分子式: C34H64O4
- 分子量:536.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
5-POHSA (5-100 μM; 5 min) activates Src kinase in cultured mouse taste bud cells in a concentration-dependent manner[1].
5-POHSA (20 μM) significantly increases calcium influx in mouse taste bud cells cultured in vitro via a CD36-dependent mechanism; in mock-transfected cells, its combined use with Linoleic acid (HY-N0729) produces a synergistic effect on calcium signals, while this response is attenuated in CD36 siRNA-transfected cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2161370-68-7
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分子量 536.87
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分子式 C34H64O4
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SMILES
CCCCCCCCCCCCCC(OC(CCCCCCC/C=C\CCCCCC)=O)CCCC(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
5-POHSA 関連分類
HY-W769935 関連分類
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