Cinoxacin
Based on 1 publication(s) in Google Scholar
Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 28657-80-9
- 分子式: C12H10N2O5
- 分子量:262.22
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Cinoxacin
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生物活性
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Quinolone |
Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Gram-negative aerobic bacteria (Escherichia coli, Proteus sp. etc.)
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Concentration:0-200μg/mL approximately
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Incubation Time:3-24 h
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Result:Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Indicated bacterial infected mice model[2]
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Dosage:1.7 g/kg, treated at 1 and 5 h postinfection
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Administration:Oral administration
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Result:Displayed antibacterial activity with ED50 values ranging from 8.1 to 58.6 mg/kg.
化学情報
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CAS 番号 28657-80-9
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性状 Solid
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分子量 262.22
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分子式 C12H10N2O5
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Color White to off-white
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SMILES
O=C(C1=NN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O
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別名
Compound 64716
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Chem Inf Model
Development of Machine Learning Models and the Discovery of a New Antiviral Compound against Yellow Fever Virus. [Abstract]2021 Aug 23;61(8):3804-3813. PMID: 34286575
溶剤 & 溶解度
DMSO : 8.33 mg/mL (31.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Scavone JM, et al. Cinoxacin: mechanism of action, spectrum of activity, pharmacokinetics, adverse reactions, and therapeutic indications. Pharmacotherapy. 1982 Sep-Oct;2(5):266-72. [Content Brief]
[2]. W E Wick, et al. Compound 64716, a new synthetic antibacterial agent. Antimicrob Agents Chemother. 1973 Oct;4(4):415-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8136 mL | 19.0680 mL | 38.1359 mL | 95.3398 mL |
| 5 mM | 0.7627 mL | 3.8136 mL | 7.6272 mL | 19.0680 mL | |
| 10 mM | 0.3814 mL | 1.9068 mL | 3.8136 mL | 9.5340 mL | |
| 15 mM | 0.2542 mL | 1.2712 mL | 2.5424 mL | 6.3560 mL | |
| 20 mM | 0.1907 mL | 0.9534 mL | 1.9068 mL | 4.7670 mL | |
| 25 mM | 0.1525 mL | 0.7627 mL | 1.5254 mL | 3.8136 mL | |
| 30 mM | 0.1271 mL | 0.6356 mL | 1.2712 mL | 3.1780 mL |
Cinoxacin 関連分類
HY-B1085 関連分類
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