製品番号: HY-W013049

ベヘン酸

(別名: Docosanoic acid; ドコサン酸)

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Based on 1 Customer Validation

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.40%
CAS 番号: 112-85-6
分子式: C₂₂H₄₄O₂
分子量:340.59

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Docosanoic acid 構造式

CAS 番号: 112-85-6

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価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Human Endogenous Metabolite

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

Docosanoic acid is effective at inhibiting the dsDNA binding activity of wild-type p53 DBD, with 50% inhibition observed at 0.41 nmol. The inhibitory effect of Docosanoic acid on the activities of R248A mutant p53 DBD was almost as strong as that of the wild-type^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

In rats, the percentage of Behenic acid in the diet is 1.7% and shows a significant reduction in the deposition of visceral fat, confirmed by a lower weight of adipose (epididymal and mesenteric) and hepatic tissues, as well as excreting more fatty acids in the feces when compared to the group. Behenic acid has a low bioavailability, which leads to a reduction in the absorption and as a consequence, to the reduction in body weight and deposition of visceral fat^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 112-85-6
性状 Solid
分子量 340.59
分子式 C₂₂H₄₄O₂
Color Off-white to light yellow
SMILES

CCCCCCCCCCCCCCCCCCCCCC(O)=O
別名

Docosanoic acid; ドコサン酸
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMF : 9.09 mg/mL (26.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (2.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9361 mL

14.6804 mL

29.3608 mL

5 mM

0.5872 mL

2.9361 mL

5.8722 mL

10 mM

0.2936 mL

1.4680 mL

2.9361 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 3.33 mg/mL (9.78 mM); Suspended solution; Need ultrasonic

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
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- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Cater NB, et al. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001 Jan;73(1):41-4. [Content Brief]

[2]. Moreira DK, et al. Evaluation of structured lipids with behenic acid in the prevention of obesity. Food Res Int. 2017 May;95:52-58. [Content Brief]

[3]. Iijima H, et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids. 2006 Jun;41(6):521-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / DMF	1 mM	2.9361 mL	14.6804 mL	29.3608 mL	73.4020 mL
DMF	5 mM	0.5872 mL	2.9361 mL	5.8722 mL	14.6804 mL
	10 mM	0.2936 mL	1.4680 mL	2.9361 mL	7.3402 mL
	15 mM	0.1957 mL	0.9787 mL	1.9574 mL	4.8935 mL
	20 mM	0.1468 mL	0.7340 mL	1.4680 mL	3.6701 mL
	25 mM	0.1174 mL	0.5872 mL	1.1744 mL	2.9361 mL

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ベヘン酸

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Docosanoic acid 関連分類

HY-W013049 関連分類