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製品番号: HY-13618

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Edotecarin

Name: Edotecarin
Brand: MedChemExpress
SKU: HY-13618
Price: 660.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: J 107088; PF 804950)

カスタマーレビュー

Based on 1 Customer Validation

Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC₅₀ of 50 nM.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.91%
CAS 番号: 174402-32-5
分子式: C₂₉H₂₈N₄O₁₁
分子量:608.55

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Edotecarin 構造式

CAS 番号: 174402-32-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC₅₀ of 50 nM.

IC₅₀ & Target

^[1]

Topoisomerase I

50 nM (IC₅₀)

Protein Kinase C

160 μM (IC₅₀)

Topoisomerase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	6.5 nM Compound: Edotecarin	Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay	[PMID: 22749423]
DLD-1	IC₅₀	840 nM Compound: 1	Cytotoxicity against human DLD1 cells after 72 hrs Cytotoxicity against human DLD1 cells after 72 hrs	[PMID: 19397324]
GLC4 cell line	IC₅₀	0.8 nM Compound: Edotecarin	Cytotoxicity against human GLC4 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human GLC4 cells after 72 hrs by sulforhodamine B assay	[PMID: 22749423]
MKN-45	IC₅₀	4.8 nM Compound: 2	Tested for cytotoxic activity against human stomach cancer cells (MKN-45) Tested for cytotoxic activity against human stomach cancer cells (MKN-45)	[PMID: 10743939]
MKN-45	IC₅₀	70 nM Compound: 1	Cytotoxicity against human MKN45 cells after 72 hrs Cytotoxicity against human MKN45 cells after 72 hrs	[PMID: 19397324]
NCI-H460	IC₅₀	193 nM Compound: Edotecarin	Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay	[PMID: 22749423]
P388	IC₅₀	1.5 nM Compound: 2	The compound was tested for the cytotoxic activity against murine leukemia cells (P388) The compound was tested for the cytotoxic activity against murine leukemia cells (P388)	[PMID: 10743939]
P388/S	EC₅₀	1.5 nM Compound: 1	Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS method Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS method	[PMID: 19397324]
P388/S	IC₅₀	4.8 nM Compound: 1	Cytotoxicity against mouse P388/S cells after 72 hrs by colorimetric tetrazolium-formazan method Cytotoxicity against mouse P388/S cells after 72 hrs by colorimetric tetrazolium-formazan method	[PMID: 19397324]

体外実験

In the presence of human colon cancer cells labeled with ³Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect^[1]. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 174402-32-5
性状 Solid
分子量 608.55
分子式 C₂₉H₂₈N₄O₁₁
Color Yellow to orange
SMILES

O=C1N(NC(CO)CO)C(C2=C1C3=C(C4=C2C5=C(N4[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)C=C(O)C=C5)NC7=C3C=CC(O)=C7)=O
別名

J 107088; PF 804950
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (164.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6433 mL

8.2163 mL

16.4325 mL

5 mM

0.3287 mL

1.6433 mL

3.2865 mL

10 mM

0.1643 mL

0.8216 mL

1.6433 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (281 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Saif MW, et al. Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36. [Content Brief]

[2]. Ciomei M, et al. Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model. Clin Cancer Res. 2006 May 1;12(9):2856-61. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6433 mL	8.2163 mL	16.4325 mL	41.0813 mL
	5 mM	0.3287 mL	1.6433 mL	3.2865 mL	8.2163 mL
	10 mM	0.1643 mL	0.8216 mL	1.6433 mL	4.1081 mL
	15 mM	0.1096 mL	0.5478 mL	1.0955 mL	2.7388 mL
	20 mM	0.0822 mL	0.4108 mL	0.8216 mL	2.0541 mL
	25 mM	0.0657 mL	0.3287 mL	0.6573 mL	1.6433 mL
	30 mM	0.0548 mL	0.2739 mL	0.5478 mL	1.3694 mL
	40 mM	0.0411 mL	0.2054 mL	0.4108 mL	1.0270 mL
	50 mM	0.0329 mL	0.1643 mL	0.3287 mL	0.8216 mL
	60 mM	0.0274 mL	0.1369 mL	0.2739 mL	0.6847 mL
	80 mM	0.0205 mL	0.1027 mL	0.2054 mL	0.5135 mL
	100 mM	0.0164 mL	0.0822 mL	0.1643 mL	0.4108 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外実験
純度とドキュメンテーション
参考文献

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Edotecarin

Topoisomerase アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

体外実験

体内実験

化学情報

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Edotecarin 関連分類

HY-13618 関連分類

Bioz

Keywords

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IC₅₀ & Target