Indolelactic acid
Based on 14 publication(s) in Google Scholar
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.
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- 純度: 99.95%
- CAS 番号: 1821-52-9
- 分子式: C11H11NO3
- 分子量:205.21
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
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MedChemExpress（MCE）の使用を引用している文献 Indolelactic acid
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Imeta. 2024 Jan 15;3(1):e165. [Abstract]
- Nat Immunol. 2025 Apr 11. [Abstract]
- Adv Sci (Weinh). 2025 Dec 22:e13606. [Abstract]
- Theranostics. 2024 Apr 22;14(7):2719-2735. [Abstract]
- Int J Oral Sci. 2026 Jan 27;18(1):14. [Abstract]
- Gut Microbes. 2025 Dec;17(1):2508949. [Abstract]
- Cell Rep. 2025 Aug 12;44(8):116132. [Abstract]
- J Agric Food Chem. 2025 Jul 16;73(28):17696-17712. [Abstract]
- Psoriasis (Auckl). 2026 Mar 27:16:585731. [Abstract]
- Cell Prolif. 2025 Jun;58(6):e13816. [Abstract]
- Int J Mol Sci. 2024 Jun 18;25(12):6694. [Abstract]
- Amino Acids. 2022 Oct;54(10):1421-1435. [Abstract]
- Authorea. 2026 Mar 31.
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
0.22 mM
Compound: DL-indole-3-lactic acid
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Inhibition of human recombinant KAT1 expressed in Sf9 cells
Inhibition of human recombinant KAT1 expressed in Sf9 cells
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[PMID: 19338303] |
Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells[2].
Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells[3].
Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells[3].
Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells[3].
Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 cells
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Concentration:0.1, 1, 10 mM
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Incubation Time:1 h
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Result:Decreased IL-8 level induced by TNF-α, and increased β-defensin 2 and SERT level.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice[4]
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Dosage:10 μM, 5 μL
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Administration:Gavage feeding, 5 days
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Result:Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.
化学情報
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CAS 番号 1821-52-9
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性状 Solid
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分子量 205.21
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分子式 C11H11NO3
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Color Off-white to light yellow
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SMILES
OC(C(CC1=CNC2=CC=CC=C12)O)=O
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別名
Indole-3-lactic acid
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (14)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Imeta
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway. [Abstract]2024 Jan 15;3(1):e165. PMID: 38868519
Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165. [Abstract]
Cell growth curves of colorectal cancer (CRC) cell line HCT116 cells treated with Indolelactic acid (2 μM; 2 days) and a vehicle (as negative control).
Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165. [Abstract]
HCT116 cells treated with or without Indolelactic acid (2 μM; 12 h) were stained with propidium iodide (PI) and analyzed using flow cytometry.
Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165. [Abstract]
Expression levels of cell proliferation and cell cycle-associated proteins and gut barrier function-associated proteins in HCT116 cells treated with or without Indolelactic acid (2 μM; 12 h).
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Nat Immunol
2025 Apr 11. PMID: 40217111 -
Adv Sci (Weinh)
IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR-Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma. [Abstract]2025 Dec 22:e13606. PMID: 41431173 -
Theranostics
Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages. [Abstract]2024 Apr 22;14(7):2719-2735. PMID: 38773969
Indolelactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 22;14(7):2719-2735. [Abstract]
Colitis-associated colorectal cancer (CAC) mice treate PBS, Indolelactic acid (ILA) (20 mg/kg/daily by oral gavage) and ILA+CH-223191. Representative colonic images and statistical histogram of colon length.
Indolelactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 22;14(7):2719-2735. [Abstract]
Gene expression of Il1b, Tnf, and Il10 in murine BMDMs treated Indolelactic acid (ILA) (0-1000 μM) and ILA+CH-223191.
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Int J Oral Sci
Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice. [Abstract]2026 Jan 27;18(1):14. PMID: 41587982 -
Gut Microbes
2025 Dec;17(1):2508949. PMID: 40409349 -
Cell Rep
Bifidobacterium animalis suppresses non-small cell lung cancer progression and modulates tumor immunity through indole-3-acetic acid. [Abstract]2025 Aug 12;44(8):116132. PMID: 40802513 -
J Agric Food Chem
Tryptophan-Rich Diet Improves High-Fat Diet-Induced Cognitive Dysfunction and Blood-Brain Barrier Disruption in C57BL/6 Mice through FFAR3 Activation. [Abstract]2025 Jul 16;73(28):17696-17712. PMID: 40600293 -
Psoriasis (Auckl)
Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A. [Abstract]2026 Mar 27:16:585731. PMID: 41918778 -
Cell Prolif
Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma. [Abstract]2025 Jun;58(6):e13816. PMID: 40071723 -
Int J Mol Sci
Cinnamic Acid, Perillic Acid, and Tryptophan Metabolites Differentially Regulate Ion Transport and Serotonin Metabolism and Signaling in the Mouse Ileum In Vitro. [Abstract]2024 Jun 18;25(12):6694. PMID: 38928404 -
Amino Acids
Tryptophan regulates bile and nitrogen metabolism in two pig gut lactobacilli species in vitro based on metabolomics study. [Abstract]2022 Oct;54(10):1421-1435. PMID: 35838843 -
溶剤 & 溶解度
DMSO : 100 mg/mL (487.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.98 mg/mL (9.65 mM); Clear solution
This protocol yields a clear solution of ≥ 1.98 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (19.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (97.46 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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参考文献
[2]. Bethany M Henrick, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021 Jul 22;184(15):3884-3898.e11. [Content Brief]
[3]. Amy M Ehrlich, et al. Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. BMC Microbiol. 2020 Nov 23;20(1):357. [Content Brief]
[4]. Wuyang Huang, et al. The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis. Sci Rep. 2021 Apr 13;11(1):8088. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8730 mL | 24.3649 mL | 48.7299 mL | 121.8246 mL |
| 5 mM | 0.9746 mL | 4.8730 mL | 9.7460 mL | 24.3649 mL | |
| 10 mM | 0.4873 mL | 2.4365 mL | 4.8730 mL | 12.1825 mL | |
| 15 mM | 0.3249 mL | 1.6243 mL | 3.2487 mL | 8.1216 mL | |
| 20 mM | 0.2436 mL | 1.2182 mL | 2.4365 mL | 6.0912 mL | |
| 25 mM | 0.1949 mL | 0.9746 mL | 1.9492 mL | 4.8730 mL | |
| 30 mM | 0.1624 mL | 0.8122 mL | 1.6243 mL | 4.0608 mL | |
| 40 mM | 0.1218 mL | 0.6091 mL | 1.2182 mL | 3.0456 mL | |
| 50 mM | 0.0975 mL | 0.4873 mL | 0.9746 mL | 2.4365 mL | |
| 60 mM | 0.0812 mL | 0.4061 mL | 0.8122 mL | 2.0304 mL | |
| 80 mM | 0.0609 mL | 0.3046 mL | 0.6091 mL | 1.5228 mL | |
| 100 mM | 0.0487 mL | 0.2436 mL | 0.4873 mL | 1.2182 mL |
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