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Rimonabant

(別名: SR141716)
16 Cited Publications
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Based on 16 publication(s) in Google Scholar

Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

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  • 純度 : 99.52%
  • CAS 番号: 168273-06-1
  • 分子式: C22H21Cl3N4O
  • 分子量:463.79
  • 保管条件:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Rimonabant Chemical Structure
    Rimonabant 構造式
  • Experimental Validation Results for Rimonabant
  • Experimental Validation Results for Rimonabant
  • Experimental Validation Results for Rimonabant
  • Experimental Validation Results for Rimonabant
  • Experimental Validation Results for Rimonabant
CAS 番号: 168273-06-1
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MedChemExpress（MCE）の使用を引用している文献 Rimonabant

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  • In Vivo Efficacy Study
  • Bio/Physico-chemical Assay
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  • Rimonabant Chemical Structure
    Rimonabant Chemical Structure
    1/16
  • 1/16

    Rimonabant purchased from MedChemExpress. Usage Cited in: Cell. 2025 Dec 24;188(26):7547-7570.e45 [Abstract]

    Customer Validation
     FO of WT and CNR1 KO mice treated with Rimonabant (3 mg/kg; i.p.; single dose).

  • 1/16

    Rimonabant purchased from MedChemExpress. Usage Cited in: J Psychopharmacol. 2025 Jul 31:2698811251355603. [Abstract]

    Customer Validation
     AUClog of low- and high-impulsive subpopulations for each treatment condition (Vehicle pre-treatment, Vehicle post-treatment, and Rimonabant (1 mg/kg; once every other day for 3 consecutive doses)). The results showed that Rimonabant reversed WIN55212-2-induced elevation in AUClog in rats via antagonism of the CB1 receptor.

  • 1/16

    Rimonabant purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 May 3;25(9):5012. [Abstract]

    Customer Validation
     Fluorescent signal of Rimonabant at inhibiting GRABeCB2.0 basal fluorescence as determined by averaging ΔF/F0 between 4 and 5 min. The results showed that Rimonabant suppressed the fluorescent signal to below baseline levels in stable HEK293 cells expressing the GRABeCB2.0 sensor, indicating inverse agonist activity (EC50= 42 nM).

  • 1/16

    Rimonabant purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Nov;17(11):3592-3606. [Abstract]

    Customer Validation
     Effect of various ion channel inhibitors on CBD-induced glioma cell death. U251 or LN18 cells were pretreated with Rimonabant (1 μM), SR144528 (1 μM), SEA0400 (10 μM), DIDS (10 μM), CID16020046 (1 μM), SKF96365 (1 μM), RuR (1 μM), mibefradil (2.5 uM), capsazepine (1 μM), or GSK2193874 (5 μM) for 1 h and then treated with CBD (30 μM) for 48 h. Cell viability was determined by the MTT assay. The results showed that Rimonabant failed to reverse the cell growth inhibitory effects induced by CBD.

  • 1/16

    Rimonabant purchased from MedChemExpress. Usage Cited in: Cell. 2019 Jan 24;176(3):636-648.e13. [Abstract]

    Customer Validation
     Rimonabant was found to bind to MmpL3 with a dissociation constant (Kd value) of 29 μM.

  • Rimonabant