ICMT
Isoprenylcysteine carboxyl methyltransferase
ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].
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ICMT 関連製品 (67)
関連製品 (67)
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Cysmethynil
0 ImagesCysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research.
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Farnesylthioacetic acid
0 Images製品番号: HY-118563CAS 番号: 135784-48-4Farnesylthioacetic acid is a competitive, non-substrate inhibitor of Prenylcysteine α-carboxyl methyltransferase. It acts as a non-substrate competitive inhibitor of Arabidopsis thaliana Prenylcysteine α-carboxyl methyltransferase and blocks methyltransferase activity. Farnesylthioacetic acid does not inhibit protein farnesyltransferase activity in Arabidopsis. It induces Apoptosis. Farnesylthioacetic acid regulates the subcellular localization of Ras protein, reducing the proportion of cytoplasmic Ras protein without disrupting membrane binding. It enhances ABA-induced seed dormancy, delays seed germination, and promotes maximum stomatal closure at lower exogenous ABA concentrations. Farnesylthioacetic acid can be used in studies related to promyelocytic leukemia.
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UCM-13207
0 ImagesUCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome.
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ICMT-IN-30
0 Images製品番号: HY-155433CAS 番号: 1313603-14-3ICMT-IN-30 (compound 67) is an inhibitor of ICMT (IC50=0.27 μM).
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(S)-ICMT-IN-3
0 Images製品番号: HY-157092A(S)-ICMT-IN-3 (compound ent 1-27) is an inhibitor of ICMT (IC50=0.23 μM).
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ICMT-IN-28
0 Images製品番号: HY-155431CAS 番号: 1313603-12-1ICMT-IN-28 (compound 65) is an inhibitor of ICMT (IC50=0.008 μM).
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ICMT-IN-52
0 Images製品番号: HY-157120CAS 番号: 1313602-90-2ICMT-IN-52 (compound 44) is an inhibitor of ICMT (IC50=0.052 μM).
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ICMT-IN-5
0 Images製品番号: HY-155419CAS 番号: 1313602-92-4ICMT-IN-5 (compound 46) is an inhibitor of ICMT (IC50=0.3 μM).
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ICMT-IN-34
0 Images製品番号: HY-157103CAS 番号: 1313602-85-5ICMT-IN-34 (compound 39) is an inhibitor of ICMT (IC50=0.17 μM).
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ICMT-IN-51
0 Images製品番号: HY-157119CAS 番号: 1313602-89-9ICMT-IN-51 (compound 43) is an inhibitor of ICMT (IC50=0.55 μM).
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ICMT-IN-6
0 Images製品番号: HY-157095CAS 番号: 1313602-75-3ICMT-IN-6 (compound 29) is an inhibitor of ICMT (IC50=0.09 μM).
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ICMT-IN-50
0 Images製品番号: HY-157118CAS 番号: 371940-21-5ICMT-IN-50 (compound 3) is an inhibitor of ICMT (IC50=0.31 μM).
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ICMT-IN-24
0 Images製品番号: HY-155429CAS 番号: 1313603-10-9ICMT-IN-24 (compound 63) is an inhibitor of ICMT (IC50=0.19 μM).
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ICMT-IN-15
0 Images製品番号: HY-155424CAS 番号: 1313602-98-0ICMT-IN-15 (compound 51) is an inhibitor of ICMT (IC50=0.032 μM).
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ICMT-IN-13
0 Images製品番号: HY-155422CAS 番号: 1313602-95-7ICMT-IN-13 (compound 49) is an inhibitor of ICMT (IC50=0.47 μM).
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ICMT-IN-46
0 Images製品番号: HY-157114CAS 番号: 1313602-71-9ICMT-IN-46 (compound 25) is an inhibitor of ICMT (IC50=0.556 μM).
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ICMT-IN-37
0 Images製品番号: HY-157105CAS 番号: 1313602-87-7ICMT-IN-37 (compound 41) is an inhibitor of ICMT (IC50=0.308 μM).
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ICMT-IN-27
0 Images製品番号: HY-155430CAS 番号: 1313603-11-0ICMT-IN-27 (compound 64) is an inhibitor of ICMT (IC50=0.1 μM).
