Antimalarial agent 37
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2982633-16-7
- 分子式: C32H29F6N5O2S
- 分子量:661.66
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Parasite アイソフォーム固有の製品をすべて表示
More
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
2850 nM
Compound: 33
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
|
[PMID: 38214254] |
| MCF7 | EC50 |
3540 nM
Compound: 33
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
|
[PMID: 38214254] |
Antimalarial agent 37 (0-50 nM, 72 h) exhibits antiplasmodial activities, with EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7, respectively[1].
Antimalarial agent 37 exhibits microsomal stability in mouse liver microsome with half-time of 41.4 min and clearance of 17 μL/min/mg[1].
Antimalarial agent 37 (0-5000 nM, 48 h) reveals cytotoxicity in cells HepG2 and MCF 7, with EC50 values of 2850 and 3540 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:P. falciparum Dd2 and P. falciparum 3D7 strains
-
Concentration:0-50 nM
-
Incubation Time:72 h
-
Result:Exhibited antiplasmodial activities with EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7.
-
Cell Line:HepG2, MCF7
-
Concentration:0-5000 nM
-
Incubation Time:48 h
-
Result:Revealed cytotoxicity in HepG2 and MCF7, with EC50 values of 2850 nM and 3540 nM as well as selectivity index of 92 and 114, respectively
化学情報
-
CAS 番号 2982633-16-7
-
分子量 661.66
-
分子式 C32H29F6N5O2S
-
SMILES
CCN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(NC(C4=CC(C5=CC=CS5)=CN=C4)=O)=CC(C(F)(F)F)=C3)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 37 関連分類
HY-161171 関連分類
Powered by Bioz