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製品番号: HY-N21832

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Aplysinol

Aplysinol is an orally effective TLR4 signaling pathway inhibitor. Aplysinol reduces the expression of CD14, MyD88, and NF-κB p65, and downregulates the expression and secretion of TNF-α protein as well as the secretion of IL-1β. Aplysinol restores the phagocytic activity of Kupffer cells and reduces plasma endotoxin levels. Aplysinol alleviates alcohol-induced liver histopathological changes and inhibits the elevation of liver injury biomarkers, and can be used for research related to alcoholic liver disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 6790-64-3
分子式: C₁₅H₁₉BrO₂
分子量:311.22

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aplysinol 構造式

CAS 番号: 6790-64-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

TLR4

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 15974618]
Bel-7402	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 15974618]
BGC-823	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human BGC823 cells by MTT assay Cytotoxicity against human BGC823 cells by MTT assay	[PMID: 15974618]
HCT-8	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human HCT8 cells by MTT assay Cytotoxicity against human HCT8 cells by MTT assay	[PMID: 15974618]
HeLa	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 15974618]

体外実験

Aplysinol can be isolated from the dietary-derived metabolites of the red alga Laurencia okamurai^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 6790-64-3
分子量 311.22
分子式 C₁₅H₁₉BrO₂
SMILES

C(O)[C@]12[C@](C)(C=3C(O1)=CC(C)=C(Br)C3)CC[C@@H]2C
Structure Classification
- Others
Initial Source
- Marine natural products
- Marine algae
the Red Alga Laurencia tristicha
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Chang Z, et al. Protective effect and underlying mechanism of aplysin on ethanol-induced liver injury in Rats[J]. Food Science, 2020, 41(7): 131-139.

[2]. Palaniveloo K, et al. Halogenated metabolites from the diet of Aplysia dactylomela Rang[J]. Molecules, 2020, 25(4): 815.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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Aplysinol

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示