Atherosperminine
Atherosperminine (Atherospermine) is a phosphodiesterase inhibitor. Atherosperminine inhibits growth of chloroquine-resistant Plasmodium falciparum. Atherosperminine scavenges DPPH free radicals, exhibits ferric reducing power, and chelates metal ions. Atherosperminine can be used for the research of malaria.
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- CAS 番号: 5531-98-6
- 分子式: C20H23NO2
- 分子量:309.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Plasmodium |
Atherosperminine (25-100 μM; 15 min) exerts concentration-dependent, non-specific inhibition of contractions induced by multiple agonists in isolated guinea-pig trachealis[1].
Atherosperminine (25-500 μM) induces concentration-dependent relaxation of carbachol-precontracted isolated guinea-pig trachealis with an EC50 of 117.8 μM, an effect independent of β-adrenoceptors, ATP-sensitive K+ channels, and tracheal epithelium[1].
Atherosperminine (25-50 μM; 15 min) potentiates forskolin-induced relaxation of carbachol-precontracted isolated guinea-pig trachealis by 2.4-fold and 5.0-fold, respectively[1].
Atherosperminine (50-250 μM; 5 min) concentration-dependently increases cAMP content in isolated guinea-pig trachealis without altering cGMP content[1].
Atherosperminine (25-2500 μM; 30 min) potently inhibits cAMP phosphodiesterase (IC50 = 56.8 μM) and weakly inhibits cGMP phosphodiesterase (IC50 = 693.3 μM) in guinea-pig trachealis homogenate[1].
Atherosperminine exhibits antioxidant activity, with an IC50 value of 54.53 μg/mL for DPPH radical scavenging, and demonstrates metal chelating activity with an IC50 of 42.87 μg/mL[2].
Atherosperminine exhibits antiplasmodial activity, with an IC50 value of 5.80 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 5531-98-6
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分子量 309.40
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分子式 C20H23NO2
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SMILES
CN(C)CCC1=C2C=CC3=CC=CC=C3C2=C(OC)C(OC)=C1
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別名
Atherospermine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ayu Afiqah Nasrullah, et al. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae). Molecules. 2013 Jul; 18(7): 8009–8017. [Content Brief]
[2]. C H Lin, et al. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma. Eur J Pharmacol. 1993 Jun 11;237(1):109-16. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Atherosperminine 関連分類
HY-N7648 関連分類
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