country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-P2044

Copy Link Print Information

Azumamide E

Azumamide E is a HDAC inhibitor, with an IC₅₀ of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 585535-37-1
分子式: C₂₇H₃₈N₄O₆
分子量:514.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

Azumamide E 構造式

CAS 番号: 585535-37-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

HDAC1

1..22 μM (IC₅₀)

HDAC4

2.28 μM (IC₅₀)

HDAC アイソフォーム固有の製品をすべて表示 :

体外実験

Azumamide E (Compound 5) potently inhibits HDAC activity in human leukemia K562 cells, with an IC₅₀ of 0.064 μM^[1].
Azumamide potently inhibits HDAC1 and HDAC4 enzymes prepared from 293T cells, with IC₅₀ values of 1.22 μM and 2.28 μM, respectively, and does not inhibit HDAC6 at concentrations up to 50 μM^[2].
Azumamide E (0-19 μM) exhibits dose-dependent anti-angiogenic activity in an in vitro vascular formation model using mouse induced pluripotent stem cells (iPS cells), with potent inhibitory effects observed at 1.9 μM and activity detectable at 0.19 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 585535-37-1
分子量 514.62
分子式 C₂₇H₃₈N₄O₆
配列

Cyclo({d-Ala}-{d-Phe}-{Oaa}-{d-Val})
シーケンスの短縮

Cyclo(af-{Oaa}-v)
Structure Classification
- Cyclopeptides
- Peptides
Initial Source
- Marine natural products
- Sponge
Marine Sponge Mycale izuensis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Nakao Y, et al. Azumamides A-E: histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7553-7. [Content Brief]

[2]. Nakao Y, et al. Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008;18(9):2982-2984. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Azumamide E

HDAC アイソフォーム固有の製品をすべて表示