BI-1124
BI-1124 is a cathepsin S inhibitor that exhibits simulated sufficient ocular pharmacokinetic-pharmacodynamic coverage in rabbit models via topical ocular administration. BI-1124 can be used for the research of age-related dry eye disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 752237-69-7
- 分子式: C22H39N5O3
- 分子量:421.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Cathepsin アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
cathepsin S |
体外実験
BI-1124 (0.075 mg/mL, 0.0075% w/v) exhibits high corneal permeability, sufficient solubility, and a suitable partition coefficient at pH 7.4 in in silico ADMET and ocular pharmacokinetic analyses. After simulated topical administration, its concentrations in rabbit cornea and conjunctiva can remain sustained above the in vitro IC50 (7 nM) and IC90 (70 nM) levels, which supports its potential to be repurposed for age-related dry eye disease through the inhibition of cathepsin S[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 752237-69-7
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分子量 421.59
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分子式 C22H39N5O3
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SMILES
N(C([C@@H](NC(=O)N1CCOCC1)CCC(C)(C)C)=O)C2(C#N)CCN(CCC)CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BI-1124 関連分類
HY-171925 関連分類
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