BTR2000 TFA
Based on 1 Customer Validation
BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 TFA can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.95%
- 分子式: C31H43F3N6O9S2
- 分子量:764.83
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
化学情報
-
性状 Solid
-
分子量 764.83
-
分子式 C31H43F3N6O9S2
-
Color White to off-white
-
SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSCC3=CC=CC2=C3)N.O=C(O)C(F)(F)F
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 62.5 mg/mL (81.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Farrell BM, et, al. A synthetic KLHL20 ligand to validate CUL3KLHL20 as a potent E3 ligase for targeted protein degradation. Genes Dev. 2022 Sep 1;36(17-18):1031-1042. [Content Brief]
[2]. Fechtmeyer PH, et, al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv. 2024 Dec 7:2024.12.07.627262. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3075 mL | 6.5374 mL | 13.0748 mL | 32.6870 mL |
| 5 mM | 0.2615 mL | 1.3075 mL | 2.6150 mL | 6.5374 mL | |
| 10 mM | 0.1307 mL | 0.6537 mL | 1.3075 mL | 3.2687 mL | |
| 15 mM | 0.0872 mL | 0.4358 mL | 0.8717 mL | 2.1791 mL | |
| 20 mM | 0.0654 mL | 0.3269 mL | 0.6537 mL | 1.6344 mL | |
| 25 mM | 0.0523 mL | 0.2615 mL | 0.5230 mL | 1.3075 mL | |
| 30 mM | 0.0436 mL | 0.2179 mL | 0.4358 mL | 1.0896 mL | |
| 40 mM | 0.0327 mL | 0.1634 mL | 0.3269 mL | 0.8172 mL | |
| 50 mM | 0.0261 mL | 0.1307 mL | 0.2615 mL | 0.6537 mL | |
| 60 mM | 0.0218 mL | 0.1090 mL | 0.2179 mL | 0.5448 mL | |
| 80 mM | 0.0163 mL | 0.0817 mL | 0.1634 mL | 0.4086 mL |
BTR2000 TFA 関連分類
HY-172563A 関連分類
Powered by Bioz