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製品番号: HY-164465

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C086

C086, a novel potent Hsp90 inhibitor, could inhibit cell cycle progression and induce cell apoptosis and anti-metastasis by regulating various mechanisms in different cell types.

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CAS 番号: 1160107-44-7
分子式: C₂₉H₂₈O₈
分子量:504.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

C086 構造式

CAS 番号: 1160107-44-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

C086, a novel potent Hsp90 inhibitor, could inhibit cell cycle progression and induce cell apoptosis and anti-metastasis by regulating various mechanisms in different cell types^[1].

HSP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Colon 26	IC₅₀	8.91 μM Compound: C086	Cytotoxicity against mouse Colon 26 cells after 4 hrs by MTT assay Cytotoxicity against mouse Colon 26 cells after 4 hrs by MTT assay	[PMID: 31336310]
HT-29	IC₅₀	5.42 μM Compound: C086	Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay	[PMID: 31336310]
KM12	IC₅₀	3.9 μM Compound: C086	Cytotoxicity against human KM12 cells after 4 hrs by MTT assay Cytotoxicity against human KM12 cells after 4 hrs by MTT assay	[PMID: 31336310]
SW480	IC₅₀	4.78 μM Compound: C086	Cytotoxicity against human SW480 cells after 4 hrs by MTT assay Cytotoxicity against human SW480 cells after 4 hrs by MTT assay	[PMID: 31336310]
WiDr	IC₅₀	7.32 μM Compound: C086	Cytotoxicity against human WiDr cells after 4 hrs by MTT assay Cytotoxicity against human WiDr cells after 4 hrs by MTT assay	[PMID: 31336310]

体外実験

C086 combined with Gefitinib damages the molecular chaperone functions of Hsp90 in NSCLC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1160107-44-7
分子量 504.53
分子式 C₂₉H₂₈O₈
SMILES

O=C(/C=C/C1=CC=C(O)C(OC)=C1)C(CC2=CC(OC)=C(O)C=C2)C(/C=C/C3=CC(OC)=C(O)C=C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liman Wang, et al. Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib. Cancer Manag Res. 2019 Oct 16:11:8937-8945. [Content Brief]

Calculators

モル濃度計算機

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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C086

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