CS1
CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis.
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- CAS 番号: 1448009-94-6
- 分子式: C16H12O3
- 分子量:252.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
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topoisomerase II alpha |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
11.5 μM
Compound: 1
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Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
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[PMID: 25240702] |
| HeLa | IC50 |
4.6 μM
Compound: 1
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Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay
|
[PMID: 25240702] |
| MDA-MB-231 | IC50 |
4.3 μM
Compound: 1
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
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[PMID: 25240702] |
| MDA-MB-231 | IC50 |
4.3 μM
Compound: CS1
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Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by CCK8 assay
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[PMID: 36063665] |
CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively[1]
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CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)[1].
CS1 (0-20 µM) shows antiproliferation activity in cancer cells[1].
CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase[1].
CS1 (2.5, 5, 10 µM) induces cell apoptosis[1].
CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old female athymic nude mice (BALB/c-nu)[1]
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Dosage:20 mg/kg
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Administration:i.v., every other day for two weeks
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Result:Showed antitumor effects.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1448009-94-6
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分子量 252.26
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分子式 C16H12O3
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SMILES
OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CS1 関連分類
HY-137005 関連分類
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