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製品番号: HY-123925

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CSLP43

CSLP43 is a selective RIPK2 and XIAP inhibitor with an IC₅₀ of 19.9 nM against human RIPK2. CSLP43 binds to the ATP-binding pocket of RIPK2 and disrupts the interaction between RIPK2 and the BIR2 domain of XIAP or cIAP1. CSLP43 inhibits RIPK2 ubiquitination, NOD1-dependent inflammatory signaling pathways, NOD2-dependent inflammatory signaling pathways, as well as NF-κB activation associated with NOD agonists. CSLP43 is selective for the NOD1/NOD2 signaling pathway and does not inhibit the kinase activity of RIPK1 or RIPK3. CSLP43 is applicable to research related to Crohn's disease, Blau syndrome, early-onset sarcoidosis and early-onset inflammatory bowel disease.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2244988-80-3
分子式: C₂₆H₃₃N₅O₄S
分子量:511.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CSLP43 構造式

CAS 番号: 2244988-80-3

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

RIPK2

19.9 nM (IC₅₀)

XIAP

NOD2

NOD1

RIP kinase アイソフォーム固有の製品をすべて表示 :

IAP アイソフォーム固有の製品をすべて表示 :

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示 :

体外実験

CSLP43 inhibits NOD2-mediated NF-κB activation in HEKBlue hNOD2 cells with an IC₅₀ of 1.3 nM^[1].
CSLP43 binds to intracellular RIPK2 in HEKBlue cells, with an IC₅₀ of 10.1 nM and a residence time of 106.9 min^[1].
CSLP43 (0-1 μM; 4 h) inhibits L18-MDP (HY-148690)-induced CXCL8 production in U2OS/NOD2 cells^[1].
CSLP43 inhibits MDP-induced TNF release in RAW264.7 macrophages with an IC₅₀ of 1.2 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

RAW264.7 mouse macrophages
Concentration:

serial dilutions
Incubation Time:

24 h (with MDP stimulation)
Result:

Inhibited MDP-induced TNF release with an IC₅₀ of 1.2 nM.

Western Blot Analysis^[1]

Cell Line:

U2OS/NOD2 cell
Concentration:

0, 10, 50, 250, 1000 nM
Incubation Time:

4 h with L18-MDP stimulation
Result:

Dose-dependently inhibited L18-MDP-induced CXCL8 production in U2OS/NOD2 cells

化学情報

CAS 番号 2244988-80-3
分子量 511.64
分子式 C₂₆H₃₃N₅O₄S
SMILES

O=S(=O)(NC=1C=C(C=C(OC)C1OC)C2=CC(=CN=C2N)C=3C=CC(=CC3)N4CCNCC4)CCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hrdinka M, et al. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018;37(17):e99372. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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CSLP43

RIP kinase アイソフォーム固有の製品をすべて表示

IAP アイソフォーム固有の製品をすべて表示

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CSLP43 関連分類

HY-123925 関連分類