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製品番号: HY-162423

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CYB210010

CYB210010 is an orally bioavailable, long-acting serotonin 5-HT2 receptor agonist that selectively targets 5-HT2A and 5-HT2C receptors (EC₅₀: 4.1 n, 7.3 nM). CYB210010 can enter the central nervous system, cause a head twitch response (HTR), and is not prone to behavioral tolerance during chronic administration.

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CAS 番号: 2762568-47-6
分子式: C₁₁H₁₅ClF₃NO₂S
分子量:317.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CYB210010 構造式

CAS 番号: 2762568-47-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

5-HT_2A Receptor

5-HT_2C Receptor

5-HT_1A Receptor

32 nM (Ki)

5-HT_1B Receptor

949 nM (Ki)

5-HT₆ Receptor

1301 nM (Ki)

5-HT₇ Receptor

4918 nM (Ki)

5-HT_2A Receptor

4.1 nM (EC₅₀)

5-HT_2C Receptor

7.3 nM (EC₅₀)

5-HT_2B Receptor

88 nM (EC₅₀)

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

CYB210010 has certain oral bioavailability and can smoothly enter the central nervous system, bind to 5-HT2A receptors in the frontal cortex, and increase the expression of neuroplasticity-related genes in the frontal cortex^[1].
CYB210010 (0.1-3 mg/kg; sc; single dose) causes a head twitch response (HTR) in mouse, and can be administered subchronically at threshold doses without developing behavioral tolerance^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6J mice^[1]
Dosage:

0.1, 0.3, 1, 3, mg/kg
Administration:

sc; sigle dose
Result:

Elicited maximum HTRs at ∼15 min postadministration which terminated after 220 min (significant from vehicle from 5-160 min).

化学情報

CAS 番号 2762568-47-6
分子量 317.76
分子式 C₁₁H₁₅ClF₃NO₂S
SMILES

COC1=C(CCN)C=C(OC)C(SC(F)(F)F)=C1.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Varty GB, et al. Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist. J Med Chem. 2024 Apr 25;67(8):6144-6188. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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CYB210010

5-HT Receptor アイソフォーム固有の製品をすべて表示