cyclo(CLLFVY)
Based on 1 Customer Validation
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.37%
- CAS 番号: 1446322-73-1
- 分子式: C38H54N6O7S
- 分子量:738.94
-
保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
VEGFR アイソフォーム固有の製品をすべて表示
More
生物活性
化学情報
-
CAS 番号 1446322-73-1
-
性状 Solid
-
分子量 738.94
-
分子式 C38H54N6O7S
-
Color White to off-white
-
配列
cyclo(Cys-Leu-Leu-Phe-Val-Tyr)
-
シーケンスの短縮
cyclo(CLLFVY)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (135.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (279 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3533 mL | 6.7664 mL | 13.5329 mL | 33.8322 mL |
| 5 mM | 0.2707 mL | 1.3533 mL | 2.7066 mL | 6.7664 mL | |
| 10 mM | 0.1353 mL | 0.6766 mL | 1.3533 mL | 3.3832 mL | |
| 15 mM | 0.0902 mL | 0.4511 mL | 0.9022 mL | 2.2555 mL | |
| 20 mM | 0.0677 mL | 0.3383 mL | 0.6766 mL | 1.6916 mL | |
| 25 mM | 0.0541 mL | 0.2707 mL | 0.5413 mL | 1.3533 mL | |
| 30 mM | 0.0451 mL | 0.2255 mL | 0.4511 mL | 1.1277 mL | |
| 40 mM | 0.0338 mL | 0.1692 mL | 0.3383 mL | 0.8458 mL | |
| 50 mM | 0.0271 mL | 0.1353 mL | 0.2707 mL | 0.6766 mL | |
| 60 mM | 0.0226 mL | 0.1128 mL | 0.2255 mL | 0.5639 mL | |
| 80 mM | 0.0169 mL | 0.0846 mL | 0.1692 mL | 0.4229 mL | |
| 100 mM | 0.0135 mL | 0.0677 mL | 0.1353 mL | 0.3383 mL |
Powered by Bioz