Dehydrobruceine B
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2.
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- CAS 番号: 53730-90-8
- 分子式: C23H26O11
- 分子量:478.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Bax |
Bcl-xL |
Bcl-2 |
体外実験
Dehydrobruceine B (1 μM; 48 h) and Cisplatin (3-18 μM; 48 h) combination synergizes the cytotoxic and apoptotic effects in A549 cells[1].
Dehydrobruceine B (1 μM; 24 h) induces excessive generation of intracellular ROS in Cisplatin (3 μM, 6 μM; 24 h)-treated A549 cells[1].
Dehydrobruceine B (1 μM; 24 h) increases depolarization of mitochondrial membrane potential (MMP) and translocation of cytochrome c in Cisplatin (3 μM, 6 μM; 24 h)-treated A549 cells[1].
Dehydrobruceine B (1 μM; 24 h) enhances the change of anti-apoptotic and pro-apoptotic protein levels in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:1 μM; with or without Cisplatin
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Incubation Time:48 hours
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Result:Upregulated the protein level of Bax, while downregulated the levels of Bcl-2 and Bcl-xL.
Enhanced caspase activation and PARP cleavage.
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Cell Line:A549 cells
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Concentration:1 μM; with or without Cisplatin
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Incubation Time:48 hours
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Result:Inhibited cell viability with 9 μM and 18 μM Cisplatin, respectively.
Induced cell apoptosis with 3 μM and 6 μM Cisplatin, respectively.
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Cell Line:A549 cells
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Concentration:1 μM; with or without 3 μM and 6 μM Cisplatin, respectively
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Incubation Time:24 hours
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Result:Resulted apoptosis-inducing factor (AIF) translocated from cytosol into nucleus dramatically in the co-treatment condition.
化学情報
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CAS 番号 53730-90-8
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分子量 478.45
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分子式 C23H26O11
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SMILES
COC([C@]12[C@@]3([H])[C@@]4(CO2)[C@@]([C@H]([C@@H]1O)O)([H])[C@@]5(C(C[C@@]4([H])OC([C@@H]3OC(C)=O)=O)=C(C(C(O)=C5)=O)C)C)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dehydrobruceine B 関連分類
HY-N10313 関連分類
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