DHTP
Based on 1 Customer Validation
DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.42%
- CAS 番号: 1620225-37-7
- 分子式: C25H21ClN2O6S
- 分子量:512.96
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Kinesin アイソフォーム固有の製品をすべて表示
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生物活性
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Kif2a 1.2 μM (IC50) |
Kif2c/MCAK 4.6 μM (IC50) |
DHTP (0.01-100 μM) inhibits kinesin-13 ATPase activity selectively (IC50 MCAK=4.6 μM, Kif2a=1.2 μM)[1].
DHTP (5 μM, 10 μM, 20 μM) selectively reduces MCAK-induced microtubule depolymerization rate (74% at 5 μM, 89% at 10 μM) without affecting Eg5-driven gliding[1].
DHTP (10 μM; 15-20 minutes post-treatment) modulates microtubule dynamics in Drosophila S2 cells, increasing pause time and persistent growth while reducing catastrophe frequency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1620225-37-7
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性状 Solid
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分子量 512.96
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分子式 C25H21ClN2O6S
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Color Light yellow to yellow
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SMILES
C(OC(C)C)(=O)C=1C(N2C(S/C(=C\C3=CC=C(OCC(O)=O)C=C3)/C2=O)=NC1)C4=CC=C(Cl)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (97.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
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- Deutsch - DE (252 KB)
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- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9495 mL | 9.7473 mL | 19.4947 mL | 48.7367 mL |
| 5 mM | 0.3899 mL | 1.9495 mL | 3.8989 mL | 9.7473 mL | |
| 10 mM | 0.1949 mL | 0.9747 mL | 1.9495 mL | 4.8737 mL | |
| 15 mM | 0.1300 mL | 0.6498 mL | 1.2996 mL | 3.2491 mL | |
| 20 mM | 0.0975 mL | 0.4874 mL | 0.9747 mL | 2.4368 mL | |
| 25 mM | 0.0780 mL | 0.3899 mL | 0.7798 mL | 1.9495 mL | |
| 30 mM | 0.0650 mL | 0.3249 mL | 0.6498 mL | 1.6246 mL | |
| 40 mM | 0.0487 mL | 0.2437 mL | 0.4874 mL | 1.2184 mL | |
| 50 mM | 0.0390 mL | 0.1949 mL | 0.3899 mL | 0.9747 mL | |
| 60 mM | 0.0325 mL | 0.1625 mL | 0.3249 mL | 0.8123 mL | |
| 80 mM | 0.0244 mL | 0.1218 mL | 0.2437 mL | 0.6092 mL |
DHTP 関連分類
HY-177898 関連分類
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