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製品番号: HY-146724

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Dot1L-IN-7

Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells.

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CAS 番号: 2580940-76-5
分子式: C₂₃H₂₇N₉O₂
分子量:461.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Dot1L-IN-7 構造式

CAS 番号: 2580940-76-5

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target_[1]

DOT1L

1 μM (IC₅₀)

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	IC₅₀	1 μM Compound: 25	Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 11 days by hemocytometry Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 11 days by hemocytometry	[PMID: 31978781]
Bone marrow cell	IC₅₀	4.2 μM Compound: 25	Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 9 days by hemocytometry Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 9 days by hemocytometry	[PMID: 31978781]
Bone marrow cell	IC₅₀	8.8 μM Compound: 25	Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 6 days by hemocytometry Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 6 days by hemocytometry	[PMID: 31978781]

化学情報

CAS 番号 2580940-76-5
分子量 461.52
分子式 C₂₃H₂₇N₉O₂
SMILES

CC(C)(C1=CC=C(C=C1)NC(C2=NN(C=N2)CC(NCCN3C=CC4=C3N=CN=C4N)=O)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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Dot1L-IN-7

Histone Methyltransferase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Dot1L-IN-7 関連分類

HY-146724 関連分類