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Elsunersen

(別名: PRAX-222)

Elsunersen (PRAX‑222) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability. Elsunersen combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen can be used in research related to epileptic encephalopathy.

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  • CAS 番号: 2756001-75-7
  • 分子式: C230H320N67O126P19S13
  • 分子量:7044.71
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Elsunersen Chemical Structure
    Elsunersen 構造式
CAS 番号: 2756001-75-7
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Assay Types
  • Elsunersen Chemical Structure
    Elsunersen Chemical Structure DNA, d([2′-O-(2-methoxyethyl)](m5rC-sp-m5rC-rA-m5rC-rG-rA)-m5C-sp-A-sp-T-sp-A-sp-T-sp-T-sp-T-sp-T-sp-T-sp-m5C-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA)
    1/16
  • DNA, d([2′-O-(2-methoxyethyl)](m5rC-sp-m5rC-rA-m5rC-rG-rA)-m5C-sp-A-sp-T-sp-A-sp-T-sp-T-sp-T-sp-T-sp-T-sp-m5C-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA)