Endochin
Based on 1 Customer Validation
Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.41%
- CAS 番号: 354155-51-4
- 分子式: C18H25NO2
- 分子量:287.40
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Plasmodium |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: Endochin
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Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
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[PMID: 24720377] |
| HepG2 | IC50 |
>10 μM
Compound: Endochin
|
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
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[PMID: 24720377] |
| J774 | EC50 |
>34.8 μM
Compound: 1
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Cytotoxicity against mouse J774 cells
Cytotoxicity against mouse J774 cells
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[PMID: 20828199] |
Endochin inhibits cytochrome c reduction by the T. gondii cytochrome bc1 complex, with an IC50 of 8.2 nM[1].
Endochin inhibits T. gondii with an IC50 of 0.003 nM[1].
Endochin (Compound 1) inhibits multidrug resistant W2 and TM90-C2B isolates of Plasmodium falciparum, with IC50s of 8.59 and 46.6 nM respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 354155-51-4
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性状 Solid
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分子量 287.40
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分子式 C18H25NO2
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Color White to off-white
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SMILES
O=C1C(CCCCCCC)=C(C)NC2=C1C=CC(OC)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41. [Content Brief]
[2]. Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Endochin 関連分類
HY-13833 関連分類
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