Eupolauridine
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 58786-39-3
- 分子式: C14H8N2
- 分子量:204.23
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Topoisomerase I |
Topoisomerase II |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
35.7 μM
Compound: 5
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Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
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[PMID: 21504145] |
| NCI-H460 | IC50 |
>100 μM
Compound: 5
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Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
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[PMID: 21504145] |
| SK-OV-3 | IC50 |
>10 μg/mL
Compound: Eupo
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Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
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[PMID: 27769668] |
| Vero | IC50 |
>10 μg/mL
Compound: Eupo
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Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
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[PMID: 27769668] |
化学情報
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CAS 番号 58786-39-3
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分子量 204.23
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分子式 C14H8N2
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SMILES
C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4
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別名
Canangine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Khan SI, et al. Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother. 2002 Jun;46(6):1785-92. [Content Brief]
[2]. Lavanya M, et al. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines. Top Curr Chem (Cham). 2021 Feb 24;379(2):13. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Eupolauridine 関連分類
HY-N15319 関連分類
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