FTI-2628
FTI-2628 is an antimalarial agent and a farnesyl transferase inhibitor, with an IC50 of 41.7 nM against TbPET. FTI-2628 attenuates glucose-stimulated insulin secretion. FTI-2628 exhibits antimalarial activity against Trypanosoma brucei.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 655234-81-4
- 分子式: C31H34N4O3S
- 分子量:542.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
Trypanosoma |
体外実験
化学情報
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CAS 番号 655234-81-4
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分子量 542.69
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分子式 C31H34N4O3S
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SMILES
O=C(OCC1=CC=CC=C1)[C@H](CCSC)NC(C2=C(C3=C(C=CC=C3)C)C=C(C=C2)CNCC4=CN=CN4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
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Human Islet Cell Culture
The method of preserving islets in vitro, with purified reduced immunogenicity. The steps are islet isolation, islet cell purification, in vitro determination of islet function and islet cell culture.
純度とドキュメンテーション
参考文献
[1]. Ohkanda J, et al. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of medicinal chemistry. 2004 Jan 15;47(2):432-45. [Content Brief]
[2]. Matti A, et al. Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets. 2012 Jan-Feb;4(1):74-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FTI-2628 関連分類
HY-183458 関連分類
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