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製品番号: HY-177148

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G256

G256 is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 can be used for research on arrhythmias.

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CAS 番号: 134867-97-3
分子式: C₁₄H₁₄ClN₅
分子量:287.75

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

G256 構造式

CAS 番号: 134867-97-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cytochrome P450 アイソフォーム固有の製品をすべて表示 :

体外実験

G256 (compound 1) undergoes P450-dependent N-hydroxylation catalyzed by rabbit liver microsomes to form NOH-G256, with a K_m value of 62.9 μM^[1].
G256 undergoes N-hydroxylation catalyzed by rat liver microsomes to form NOH-G256^[1].
G256 undergoes N-hydroxylation to form NOH-G256 under the catalysis of recombinant systems rich in rabbit liver P450 or purified recombinant P4502C3 systems^[1].
G256 undergoes aromatic hydroxylation catalyzed by rabbit and rat liver microsomes as well as the recombinant rabbit liver P450 monooxygenase system to form phenolic metabolites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

G256 (compound 1) is a cytochrome P450 substrate. In vivo animal experiments confirm that its antiarrhythmic activity meets the Vaughan-Williams classification criteria and exhibits characteristics of class Ⅰ antiarrhythmic drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 134867-97-3
分子量 287.75
分子式 C₁₄H₁₄ClN₅
SMILES

N=C(N)N/N=C(C1=CC=CC=C1)\C2=C(N)C=CC(Cl)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Clement B, et al. Cytochrome P450-dependent N-hydroxylation of an aminoguanidine (amidinohydrazone) and microsomal retroreduction of the N-hydroxylated product. Xenobiotica; the fate of foreign compounds in biological systems. 1994 Jul;24(7):671-88. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
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化学情報
純度とドキュメンテーション
参考文献

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G256

Cytochrome P450 アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

G256 関連分類

HY-177148 関連分類