GALT - galactose-1-phosphate uridylyltransferase Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2592

About GALT

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,646,675-34,651,035 (from NCBI)

This gene has 29 transcripts (splice variants), 168 orthologues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 23.8), liver (RPKM 21.4) and 25 other tissues.

Summary

Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GALT Products (2)

mRNA Protein Name
NM_000155.4 NP_000146.2 galactose-1-phosphate uridylyltransferase isoform 1
NM_001258332.2 NP_001245261.1 galactose-1-phosphate uridylyltransferase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity EXP
EXP: Inferred from Experiment
1897530 GOA
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IDA
IDA: Inferred from direct assay
27005423 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
27005423 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in UDP-glucose metabolic process IDA
IDA: Inferred from direct assay
27005423 GOA
involved in galactose metabolic process IDA
IDA: Inferred from direct assay
27005423 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in Golgi apparatus IDA
IDA: Inferred from direct assay
20605918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALT Protein Structure

GalP_UDP_transf

GalP_UDP_transf: Galactose-1-phosphate uridyl transferase, N-terminal domain (23 - 196)

GalP_UDP_tr_C

GalP_UDP_tr_C: Galactose-1-phosphate uridyl transferase, C-terminal domain (203 - 368)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
Protein Preferred Names Protein Names

galactose-1-phosphate uridylyltransferase

  • UDP-glucose--hexose-1-phosphate uridylyltransferase

GALT Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
GALT P07902 GRPEL1 Homo sapiens Q9HAV7
Validated Y2H
32296183
Intra
GALT P07902 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
GALT P07902 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
GALT P07902 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
GALT P07902 TNK2 Homo sapiens Q07912-2
Y2H Array
25910212
Intra
GALT P07902 TNK2 Homo sapiens Q07912-2
Y2H Bait-Prey Pool
25910212
Intra
GALT P07902 TNK2 Homo sapiens Q07912-2
Validated Y2H
25910212
Intra
GALT P07902 UBTD2 Homo sapiens Q8WUN7
Validated Y2H
32296183
Intra
GALT P07902 UBTD2 Homo sapiens Q8WUN7
Y2H Array
32296183
Intra
GALT P07902 UBTD2 Homo sapiens Q8WUN7
Y2H Prey Pooling
32296183
Intra
GALT P07902 TRIP13 Homo sapiens Q15645
Y2H Array
26871637
Intra
GALT P07902 TRIP13 Homo sapiens Q15645
Validated Y2H
26871637
Intra
GALT P07902 TRIP13 Homo sapiens Q15645
Y2H Pooling
16189514
Intra
GALT P07902 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
26871637
Intra
GALT P07902 NQO1 Homo sapiens P15559
Validated Y2H
32296183
Intra
GALT P07902 NQO1 Homo sapiens P15559
Y2H Array
32296183
Intra
GALT P07902 NQO1 Homo sapiens P15559
Y2H Prey Pooling
32296183
Intra
GALT P07902 TNK2 Homo sapiens Q07912
Validated Y2H
25416956
Intra
GALT P07902 TNK2 Homo sapiens Q07912
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

GALT 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83180 GALT Antibody (YA2925) WB, IP Human, Mouse, Rat
HY-P83180A GALT Antibody (YA2925)(PBS only) WB, IP Human, Mouse, Rat

関連疾患

Diseases Alias
Galactosemia I

  • Galactosemia

  • Galt Deficiency

  • Classic Galactosemia

  • Galactose-1-Phosphate Uridylyltransferase Deficiency

  • Galactose-1-Phosphate Uridyltransferase Deficiency

  • GALAC1

  • Galactosemia, Classic

  • Galactosemia Type 1

  • Galactosemias

  • Classical Galactosemia

  • Galactosaemia

  • Galactose Intolerance

  • Epimerase Deficiency Galactosemia

  • Galactokinase Deficiency Disease

  • Galactose Epimerase Deficiency

  • Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease

  • Gale Deficiency

  • Galk Deficiency

  • Udp-Galactose-4-Epimerase Deficiency Disease

  • Utp Hexose-1-Phosphate Uridylyltransferase Deficiency

  • Galactosemia 1

  • Galactosemia, Duarte Variant

  • Deficiency Of Galactokinase

  • Udpglucose 4-Epimerase Deficiency Disease

  • Classical Galactosaemia

  • Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency

  • Classic Galactosaemia

  • Deficiency Of Hexose-1-Phosphate Uridylyltransferase

  • Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase

  • Deficiency Of Galactose-1-Phosphate Uridylyltransferase

  • Galactose-1-Phosphate Uridyl Transferase Deficiency

  • Transferase Deficiency Galactosemia

  • Deficiency Of Uridyl Transferase

  • Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase

  • Utp-Hexose-1-Phosphate Uridyltransferase Deficiency
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Galactosemia Ii

  • Galactokinase Deficiency

  • Galk Deficiency

  • Galactokinase Deficiency With Cataracts

  • Deficiency Of Galactokinase

  • GALAC2

  • Galk-D

  • Galactokinase Deficiency Galactosemia

  • Galactosemia 2

  • Galactosemia Type 2

  • Hereditary Galactokinase Deficiency

  • Galactokinase Deficiency, Cataract

  • Galactosemias

  • Galk - [Galactokinase Deficiency]
Galactosemia Iii

  • Galactose Epimerase Deficiency

  • Gale Deficiency

  • Udp-Galactose-4-Epimerase Deficiency

  • Epimerase Deficiency Galactosemia

  • Galactosemia Type 3

  • Gale-D

  • Uridine Diphosphate Galactose-4-Epimerase Deficiency

  • GALAC3

  • Galactosemia 3

  • Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency

  • Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency

  • Galactosemia Type Iii

  • Udp-Galactose-4'-Epimerase Deficiency

  • Generalized Galactose Epimerase Deficiency

  • Generalized Gale Deficiency

  • Generalized Gale-D

  • Generalized Udp-Galactose-4-Epimerase Deficiency

  • Generalized Epimerase Deficiency Galactosemia

  • Erythrocyte Galactose Epimerase Deficiency

  • Erythrocyte Gale Deficiency

  • Erythrocyte Gale-D

  • Erythrocyte Udp-Galactose-4-Epimerase Deficiency

  • Erythrocyte Epimerase Deficiency Galactosemia

  • Galactosemias

  • Classical Galactosemia

  • Udpglucose 4-Epimerase Deficiency Disease
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Lens Subluxation

  • Subluxation Of Lens
Ovarian Disease

  • Ovarian Dysfunction

  • Ovarian Diseases

  • Ovarian Disorders

  • Disorder Of Endocrine Ovary
Premature Ovarian Failure 1

  • Ovarian Failure, Premature

  • Fmr1-Related Primary Ovarian Insufficiency

  • Fragile X-Associated Primary Ovarian Insufficiency

  • POF1

  • Pofx

  • Hypergonadotropic Ovarian Failure, X-Linked

  • Pof

  • Primary Ovarian Insufficiency, Fragile X-Associated

  • Primary Ovarian Insufficiency 1

  • Ovarian Failure Premature

  • Premature Ovarian Failure, X-Linked

  • Fragile X Premature Ovarian Failure

  • Fmr1-Related Premature Ovarian Failure

  • Familial Premature Ovarian Failure

  • Idiopathic Familial Premature Ovarian Failure

  • Fxpoi

  • X-Linked Hypergonadotropic Ovarian Failure

  • Hypergonadotropic Ovarian Failure X-Linked

  • Poi

  • Premature Ovarian Failure X-Linked

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure-1

  • Ovarian Failure, Premature, Type 1

  • Premature Ovarian Failure, Familial

  • Premature Menopause

  • Primary Hypogonadism

  • Turner Syndrome
Hypotonia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-E70052 alpha-1,3-Galactosyltransferase (a1,3GalT) / Phase 2

Pre-clinical Phase

Bioactive Molecules (53)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-E70289 Bovin beta-1,4-galactosyltransferase 1 (Y289L) / Unkown
HY-E70285 beta-1,4-Galactosyltransferase 1 (Y285L) / Unkown
HY-113143A Galactose 1-phosphate Potassium salt 99.0% Unkown
HY-E70047 alpha-1,4-Galactosyltransferase (LgtC) / Unkown
HY-113143AS Galactose 1-phosphate-13C potassium 98.8% Unkown
HY-E70046 β-1,4-Galactosyltransferase, neisseria meningitides / Unkown
HY-E70138 β-1,4-Galactosyltransferase 7 / Unkown
HY-E70191 β-1,4-Galactosyltransferase 2 / Unkown
HY-RS01323 B4GALT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01707 C1GALT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113143 Galactose 1-phosphate / Unkown
HY-113143AS1 Galactose 1-phosphate-13C-1 potassium 99.16% Unkown
HY-156208 C2 Adamantanyl galactosylceramide (d18:1/2:0) / Unkown
HY-170663 β-1,4-GALT1-IN-1 Inhibitor / Unkown
HY-E70046A Bovine beta-1,4-Galactosyltransferase / Unkown
HY-E70060 beta-1,4-Galactosyltransferase (LgtE) / Unkown
HY-P2991 Galactose 1-phosphate uridylyltransferase / Unkown
HY-RS00012 A3GALT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00013 A4GALT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01302 B3GALT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01303 B3GALT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01304 B3GALT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01305 B3GALT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01306 B3GALT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01309 B3GLCT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01319 B4GALT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01320 B4GALT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01321 B4GALT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01322 B4GALT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01324 B4GALT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01325 B4GALT7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01708 C1GALT1C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05267 GALT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149125 Globotriaosylceramide (porcine RBC) Inhibitor / Unkown
HY-RS18003 A4galt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18013 B4galt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18760 Galt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19086 B4galt5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19435 Ggta1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20622 B3galt5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20623 B4galt3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20624 B4galt4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21231 C1galt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22079 C1galt1c1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24475 A4galt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24486 B4galt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25247 Galt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25576 B4galt5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27131 B3galt5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27132 B4galt3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27133 B4galt4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27748 C1galt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28598 C1galt1c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris GALT VGNC VGNC:41103
Bos taurus GALT VGNC VGNC:29242
Rattus norvegicus GALT RGD RGD:1306483
Felis catus GALT VGNC VGNC:97443
Mus musculus GALT MGD MGI:95638
Others GALT NCBI