AURKB - aurora kinase B Gene

Also Known as AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9212

About AURKB

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,204,731-8,210,575 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues and 2 paralogues. Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues.

Summary

This gene encodes a member of the Aurora Kinase subfamily of serine/threonine Kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These Kinases participate in the regulation of alignment and segregation of chromosomes during Mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

AURKB Products (15)

mRNA	Protein	Name
NR_132731.1
NM_001313955.2	NP_001300884.1	aurora kinase B isoform 7
NM_001313950.2	NP_001300879.1	aurora kinase B isoform 1
XM_017025311.2	XP_016880800.1	aurora kinase B isoform X3
XM_047437051.1	XP_047293007.1	aurora kinase B isoform X2
NM_001313954.2	NP_001300883.1	aurora kinase B isoform 6
NM_001313951.1	NP_001300880.1	aurora kinase B isoform 2
NM_001284526.2	NP_001271455.1	aurora kinase B isoform 3
XM_011524072.4	XP_011522374.1	aurora kinase B isoform X1
XM_047437050.1	XP_047293006.1	aurora kinase B isoform X1
NM_001313952.2	NP_001300881.1	aurora kinase B isoform 4
NM_001313953.3	NP_001300882.1	aurora kinase B isoform 5
NR_132730.2
NM_004217.4	NP_004208.2	aurora kinase B isoform 1
NM_001256834.3	NP_001243763.1	aurora kinase B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables kinase binding	IPI IPI: Inferred from physical interaction	23036704	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12689593	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	21397845	GOA
NOT enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	26829474	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18455984	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cell cycle G2/M phase transition	IDA IDA: Inferred from direct assay	33542149	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	20959462	GOA
involved in cleavage furrow formation	IDA IDA: Inferred from direct assay	16103226	GOA
involved in mitotic sister chromatid biorientation	IDA IDA: Inferred from direct assay	22371557	GOA
involved in mitotic spindle midzone assembly	IMP IMP: Inferred from mutant phenotype	16103226	GOA
involved in negative regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	20959462	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	33542149	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	33542149	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20959462	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16103226	GOA
involved in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	28751710	GOA
involved in positive regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	31804178	GOA
involved in positive regulation of mitotic sister chromatid segregation	IDA IDA: Inferred from direct assay	26829474	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in protein localization to kinetochore	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in repair of mitotic kinetochore microtubule attachment defect	IDA IDA: Inferred from direct assay	22371557	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	21820309	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of chromosome passenger complex	IPI IPI: Inferred from physical interaction	15260989	GOA
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	18195732	GOA
is active in kinetochore	IDA IDA: Inferred from direct assay	26829474	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	22024163	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	9859993	GOA
located in midbody	IDA IDA: Inferred from direct assay	17726514	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20959462	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKB Protein Structure

Pkinase

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
aurora kinase B	aurora kinase B-Sv1 aurora kinase B-Sv2 aurora- and Ipl1-like midbody-associated protein 1 aurora-1 aurora-B aurora-related kinase 2 aurora/IPL1-related kinase 2 protein phosphatase 1, regulatory subunit 48 serine/threonine kinase 12 serine/threonine-protein kinase 12 serine/threonine-protein kinase 5 serine/threonine-protein kinase aurora-B

AURKB Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	AURKB	Q96GD4	HSP90AA5P	Homo sapiens	Q58FG0	Anti Tag CoIP	33961781
Intra	AURKB	Q96GD4	HSP90AA5P	Homo sapiens	Q58FG0	Anti Tag CoIP	28514442
Intra	AURKB	Q96GD4	VRK1	Homo sapiens	Q99986	Protein Kinase Assay	29340707
Intra	AURKB	Q96GD4	KLHL13	Homo sapiens	Q9P2N7	Pull Down	17543862
Intra	AURKB	Q96GD4	KLHL9	Homo sapiens	Q9P2J3	Pull Down	17543862
Intra	AURKB	Q96GD4	USP29	Homo sapiens	Q9HBJ7	Anti Bait CoIP	38233848
Intra	AURKB	Q96GD4	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	35271311
Intra	AURKB	Q96GD4	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	AURKB	Q96GD4	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	AURKB	Q96GD4	CDC37	Homo sapiens	Q16543	BioID	29568061
Intra	AURKB	Q96GD4	CDC37	Homo sapiens	Q16543	Pull Down	29568061
Intra	AURKB	Q96GD4	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26829474
Intra	AURKB	Q96GD4	PPP2R1A	Homo sapiens	P30153	Pull Down	32707033
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	19357306
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	27332895
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Anti Bait CoIP	27332895
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	17956729
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Pull Down	29568061
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Pull Down	32707033
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	35271311
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Y2H	20739936
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	33961781
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	BioID	29568061
Intra	AURKB	Q96GD4	INCENP	Homo sapiens	Q9NQS7	PLA	21051298
Intra	AURKB	Q96GD4	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	AURKB	Q96GD4	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	AURKB	Q96GD4	HSP90AB1	Homo sapiens	P08238	Pull Down	29568061
Intra	AURKB	Q96GD4	H3-4	Homo sapiens	Q16695	Protein Kinase Assay	29340707
Intra	AURKB	Q96GD4	KAT5	Homo sapiens	Q92993	GMS	26829474
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Pull Down	16291752
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	BioID	29568061
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	27332895
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Pull Down	17099693
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	19357306
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Anti Bait CoIP	27332895
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	PLA	21051298
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	17099693
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392	Anti Bait CoIP	17681274
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392-1	Pull Down	16291752
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392-1	Anti Tag CoIP	16291752
Intra	AURKB	Q96GD4	BIRC5	Homo sapiens	O15392-2	Pull Down	16291752
Intra	AURKB	Q96GD4	TACC1	Homo sapiens	O75410-6	Anti Tag CoIP	15064709
Intra	AURKB	Q96GD4	SEPTIN1	Homo sapiens	Q8WYJ6	Anti Tag CoIP	16179162
Intra	AURKB	Q96GD4	SEPTIN1	Homo sapiens	Q8WYJ6	Y2H	16179162
Intra	AURKB	Q96GD4	NPM1	Homo sapiens	P06748	Anti Tag CoIP	24857377
Intra	AURKB	Q96GD4	NPM1	Homo sapiens	P06748	Pull Down	24857377
Intra	AURKB	Q96GD4	CDCA8	Homo sapiens	Q53HL2	PLA	21051298
Intra	AURKB	Q96GD4	CDCA8	Homo sapiens	Q53HL2	Anti Bait CoIP	20739936
Intra	AURKB	Q96GD4	CDCA8	Homo sapiens	Q53HL2	BioID	29568061
Intra	AURKB	Q96GD4	CDCA8	Homo sapiens	Q53HL2	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

AURKB 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80562	Aurora B Antibody (YA594)	WB, IP	Human
HY-P80562A	Aurora B Antibody (YA594)(PBS only)	WB, IP	Human
HY-P85045	Aurora B Antibody (YA4737)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human
HY-P86439	Aurora B Antibody (YA6131)	WB, IHC-P, ICC/IF, IP, ELISA	Human

関連疾患

Diseases	Alias
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Endometrial Serous Adenocarcinoma	Uterine Corpus Serous Adenocarcinoma Uterine Papillary Serous Carcinoma Uterine Serous Carcinoma
Nystagmus 3, Congenital, Autosomal Dominant	NYS3 Congenital Nystagmus 3 Autosomal Dominant Congenital Nystagmus 3
Polyploidy	Polyploid Polyploidy Syndrome
Nk-Cell Enteropathy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-151971	Aurora kinase-IN-3	Inhibitor	99.02%	Unkown
HY-168543	PROTAC AURKA degrader 3	Degrader	99.78%	Unkown
HY-137344A	dAURK-4 hydrochloride	Degrader	98.14%	Unkown
HY-175525	MS44	Degrader	99.89%	Unkown
HY-157480	EGFR/AURKB-IN-1	Inhibitor	99.43%	Unkown
HY-168540	PROTAC MPS1 degrader 1		99.90%	Unkown
HY-180132	PROTAC AURKA degrader 2	Degrader	98.36%	Unkown
HY-168545	SF-1	Ligand	99.50%	Unkown
HY-RS01270	AURKB Human Pre-designed siRNA Set A		/	Unkown
HY-10338A	Foretinib phosphate	Inhibitor	/	Unkown
HY-116190	CFI-401870	Inhibitor	/	Unkown
HY-120279A	CFI-400437	Inhibitor	/	Unkown
HY-123610	BRD-7880	Inhibitor	/	Unkown
HY-137344	dAURK-4	Degrader	99.93%	Unkown
HY-175526	Aurora kinase ligand-1		/	Unkown
HY-176191	Aurora kinase-IN-7	Inhibitor	/	Unkown
HY-184329	PROTAC AURKB Degrader-1		/	Unkown
HY-187366	PDGFRβ-IN-1		/	Unkown
HY-N17821	Butrin		/	Unkown
HY-RS01271	Aurkb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01272	Aurkb Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	AURKB	VGNC	VGNC:26351
Canis familiaris	AURKB	VGNC	VGNC:38312
Macaca mulatta	AURKB	VGNC	VGNC:70050
Mus musculus	AURKB	MGD	MGI:107168
Felis catus	AURKB	VGNC	VGNC:60044
Rattus norvegicus	AURKB	RGD	RGD:621625
Others	AURKB	NCBI