GT-653
Based on 1 Customer Validation
GT-653 is a selective KDM5B PROTAC degrader. GT-653 induces ubiquitination and degradation of KDM5B without altering the transcriptional level of KDM5B. GT-653 upregulates the level of H3K4me3. GT-653 activates the type I Interferon signaling pathway. GT-653 can be used for the research of prostate cancer.
(Pink: KDM5B ligand (HY-158433); Blue: Cereblon ligand (HY-103596); Black: linker (HY-W004896)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.84%
- CAS 番号: 3057627-63-8
- 分子式: C32H27N7O9
- 分子量:653.60
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
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Cereblon |
GT-653 potently degrades the KDM5B protein in 22RV1 prostate cancer cells, with a degradation rate of 68.35%[1].
GT-653 (0.1-20.0 μM; 24 h) dose-dependently decreases KDM5B protein levels and increases H3K4me3 levels in 22RV1 prostate cancer cells without altering KDM5B transcription[1].
Co-incubation with GT-653 (20 μM; 12 h) and MG132 (HY-13259) induces the formation of the KDM5B-CRBN complex in 22RV1 prostate cancer cells[1].
GT-653 (0.1-20.0 μM; 24 h, 48 h) does not significantly reduce the viability of 22RV1 prostate cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:22RV1 prostate cancer cells
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Concentration:0.1-20.0 μM
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Incubation Time:24 h, 48 h
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Result:Showed no significant effect on cell viability at any tested concentration compared to control.
化学情報
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CAS 番号 3057627-63-8
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性状 Solid
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分子量 653.60
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分子式 C32H27N7O9
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Color White to off-white
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SMILES
N#CC1=C2NC(C3=CC=C(C=C3)OCC(NCCOCCOC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=CC(N2N=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GT-653 関連分類
HY-158432 関連分類
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