ID110460002
ID110460002 possesses both full agonist activity at the μ-opioid receptor (OPRM) and agonist activity at the δ-opioid receptor (OPRD). ID110460002 acts as a potent agonist for the G protein pathways of both receptors, but exhibits only very weak partial agonist activity towards the β-arrestin-2 pathway. The agonistic potency of ID110460002 at OPRM has extremely high intrinsic activity and is unaffected by reduced receptor expression levels, while its potency at OPRD depends on receptor expression levels. ID110460002 displays tissue- or organ-dependent properties, and serves as a critical compound for investigating pain mechanisms and analgesia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1172882-21-1
- 分子式: C20H25FN4O
- 分子量:356.45
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
|
μ Opioid Receptor/MOR |
δ Opioid Receptor/DOR |
Arrestin-3/β-Arrestin 2 |
体外実験
ID110460002 acts as a full G protein agonist in HEK-293 cells overexpressing OPRM, with high intrinsic activity that resists receptor depletion, and exhibits an Emax of 77.8% upon treatment with 10 nM β-FNA (HY-160938)[1].
ID110460002 acts as a very weak partial agonist of the β-arrestin2 pathway in HEK-293 cells overexpressing OPRM, with an Emax of 15.3% relative to DAMGO (HY-P0210)[1].
ID110460002 acts as a partial G protein agonist in HEK-293 cells overexpressing OPRD, and its potency decreases with reduced receptor abundance; when treated with 1000 nM β-CNA (HY-141468), its Emax reaches 64.6%[1].
ID110460002 acts as a very weak partial agonist of the β-arrestin2 pathway in HEK-293 cells overexpressing OPRD, with an Emax of 4.7% relative to SNC80 (HY-101202)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
-
CAS 番号 1172882-21-1
-
分子量 356.45
-
分子式 C20H25FN4O
-
SMILES
O=C(NC1=CC=C(F)C=C1)NCC(C2=CC=C3C(=C2)CCN3C)N(C)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
-
RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ID110460002 関連分類
HY-W414109 関連分類
Powered by Bioz