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製品番号: HY-N22057

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Isomeldenin

Isomeldenin is a natural product derived from the leaves of Azadirachta indica. Isomeldenin possesses antifungal activity and inhibits pustule formation in Puccinia arachidis. Isomeldenin exhibits antitumor activity, showing cytotoxic activity against SK-OV-3, MCF-7, and 3SKBr cells, and also decreases Bax and increases Bcl2 expression. Isomeldenin can be used in research related to fungal infections and has potential for research related to coronavirus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 186892-52-4
分子式: C₂₈H₃₈O₅
分子量:454.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (308 KB)

Isomeldenin 構造式

CAS 番号: 186892-52-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[2]

Bax

Bcl-2

Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

体外実験

OthersAnti-cancerApoptosisFungal Infection

Others

Isomeldenin exhibits binding affinity for MERS-CoV spike glycoprotein, SARS-CoV-2 spike glycoprotein, SARS-CoV-2 main protease, and SARS-CoV-2 papain-like protease; moreover, it exhibits the strongest binding affinity for SARS-CoV-2 spike glycoprotein that binds to the human ACE2 receptor^[1].

Anti-cancer

Apoptosis

Isomeldenin (100 µg/mL; 24 h) exhibits cytotoxicity against SK-OV-3, MCF-7, and 3SKBr cell lines, with the highest mortality observed in SK-OV-3 cells^[2].
Isomeldenin decreases Bax and increases Bcl2 expression^[2].

Fungal Infection

Isomeldenin (compound 2) (0.005-5.0 μg/cm²; 48 h) reduces the formation of Puccinia arachidis rust pustules on detached Arachis hypogaea L. var. TMV-2 leaflets, achieving approximately 80% reduction at 0.005 μg/cm²^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

SK-OV-3, MCF-7, 3SKBr
Concentration:

100 µg/mL
Incubation Time:

24 h
Result:

Exhibited a death rate of 76.34% in SK-OV-3 cells.
Exhibited a death rate of 64.66% in MCF-7 cells.
Exhibited a death rate of 62.99% in 3SKBr cells.

Related Protocols :

化学情報

CAS 番号 186892-52-4
分子量 454.60
分子式 C₂₈H₃₈O₅
SMILES

C[C@]12[C@@](CC[C@@]3(C2=CC[C@H]3C4=COC=C4)C)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])[C@H]([C@H]1OC(C)=O)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (308 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Trivedi A, et al. Prophylactic and therapeutic potential of selected immunomodulatory agents from Ayurveda against coronaviruses amidst the current formidable scenario: an analysis. Journal of biomolecular structure & dynamics. 2022;40(20):9648-9700.

[2]. Alaa Naseer Mohammed Ali, et al. Niosomes Containing Isomeldenin Plus Lupeol Induce Apoptosis of SK-OV-3, MCF-7, and 3SKBr Cell Lines and Alter the Expression of Apoptotic Genes. JCHR. 2024 Aug.

[3]. Suresh G, et al. Antifungal fractions and compounds from uncrushed Green Leaves of Azadirachta indica. Phytoparasitica. 1997;25:33-39.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Isomeldenin

Bcl-2 Family アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Isomeldenin 関連分類

HY-N22057 関連分類

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