Kaolin
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Kaolin is a family of kaolinitic clays, which is found in the earth's crust. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Kaolin can be utilized in industrial, cosmetic and medical fields, excipient.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1332-58-7
- 分子式: Al2Si2O5(OH)4·2H2O
- 分子量:258.16
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Kaolin (50, 100 μg/mL, 72 h) combined with graphene oxide (50, 100 μg/mL, 72 h) reduces the toxicity of graphene and decreases the percentage of cells in HCT-116 cells[3].
Kaolin (100 μg/mL, 30-180 min) induces intercellular ROS generation in RAW264 cells[4].
Kaolin (100 μg/mL, 24 h) increases the concentrations of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in RAW264 cells[4].
Kaolin (100 μg/mL, 60 min) increases DNA damage in the A549 cells co-cultured with RAW264 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Kaolin (5.0/0.1 mg/mL in 0.15 M NaCl, intratracheal inoculation, lasting for 24 h-210 days) incites acute inflammatory reaction at early periods and increases in the fibroblastic activity in the focal areas in mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[4]
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Dosage:0.05 and 0.2 mg
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Administration:intratracheal instillation, lasting for 3 h
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Result:Significantly induced DNA damage in the lungs of the mice.
化学情報
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CAS 番号 1332-58-7
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性状 Solid
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分子量 258.16
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分子式 Al2Si2O5(OH)4·2H2O
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Color White to off-white
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SMILES
[Kaolin]
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別名
カオリン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
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データシート (272 KB)
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SDS (421 KB)
- English - EN (421 KB)
- Français - FR (421 KB)
- Deutsch - DE (421 KB)
- Norwegian - NO (421 KB)
- Español - ES (421 KB)
- Swedish - SV (421 KB)
- Italian - IT (421 KB)
- Korean - KR (421 KB)
- Portuguese - PT (421 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [Content Brief]
[3]. Rozhina E, et al. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Medchemcomm. 2019 Jun 10;10(8):1457-1464. [Content Brief]
[4]. Kato T, et al. Effect of physicochemical character differences on the genotoxic potency of kaolin. Genes Environ. 2017 May 1;39:12. [Content Brief]
[5]. Sahu AP, Shanker R, Zaidi SH. Pulmonary response to kaolin, mica and talc in mice. Exp Pathol (Jena). 1978;16(1-6):276-82. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Kaolin 関連分類
HY-W115786 関連分類
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- Kaolin
- 1332-58-7
- Environmental Pollutants
- TNF Receptor
- Reactive Oxygen Species (ROS)
- Biochemical Assay Reagents
- Interleukin Related
- pharmaceutical excipient
- pharmaceutical auxiliarie
- pharmaceutical ingredients
- inactive ingredients
- stability
- solubility
- processability
- absorption
- distribution
- metabolism
- and elimination (ADME)
- Inhibitor
- inhibitor
- inhibit