MAS825
Based on 1 Customer Validation
MAS825 (Arumakimig) is a bispecific monoclonal antibody targeting IL-1β and IL-18. MAS825 reduces inflammatory infiltration and pulmonary alveolar proteinosis, and improves blood oxygen saturation, exercise tolerance and quality of life. MAS825 also promotes viral clearance. MAS825 can be used in research related to systemic juvenile idiopathic arthritis complicated with interstitial lung disease or macrophage activation syndrome, as well as COVID-19.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.83%
- 分子量:144.353 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Ig(G1-kappa_G1-lambda2)
Human
|
IL-1β |
IL-18 |
MAS825 binds to and neutralizes these two cytokines to effectively block pro-inflammatory pathways.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
IgG1-lambda-kappa
ELISA, FACS, Functional assay
化学情報
-
性状 Liquid
-
分子量 144.353 kDa
-
Color Colorless to light yellow
-
SMILES
N/A
-
別名
Arumakimig
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
-
データシート (258 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)