MDL 73811
MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 123642-27-3
- 分子式: C15H23N7O3
- 分子量:349.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3 μM
Compound: AbeAdo
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In vitro Antineoplastic Activity against Human non small cell lung carcinoma A549 Cell lines
In vitro Antineoplastic Activity against Human non small cell lung carcinoma A549 Cell lines
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[PMID: 12408722] |
| HT-29 | IC50 |
>100 μM
Compound: AbeAdo
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In vitro Neoplastic Anti Activity in Human Colon adenocarcinoma HT-29 Cell lines
In vitro Neoplastic Anti Activity in Human Colon adenocarcinoma HT-29 Cell lines
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[PMID: 12408722] |
| MCF7 | IC50 |
>100 μM
Compound: AbeAdo
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In vitro Neoplastic Anti Activity against Human Breast adenocarcinoma MCF-7 Cell lines
In vitro Neoplastic Anti Activity against Human Breast adenocarcinoma MCF-7 Cell lines
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[PMID: 12408722] |
| MCF7 | IC50 |
200 μM
Compound: AbeAdo
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In vitro Antineoplastic Activity against Adriamycin resistant Human Breast adenocarcinoma MCF7-Adr Cell lines
In vitro Antineoplastic Activity against Adriamycin resistant Human Breast adenocarcinoma MCF7-Adr Cell lines
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[PMID: 12408722] |
化学情報
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CAS 番号 123642-27-3
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分子量 349.39
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分子式 C15H23N7O3
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SMILES
O[C@@H]1[C@H](O)[C@@H](CN(C)C/C=C\CN)O[C@H]1N2C=NC3=C(N)N=CN=C32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Brockway AJ, et al. Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. Bioorg Med Chem. 2017 Oct 15;25(20):5433-5440. [Content Brief]
[2]. Brockway AJ , et al. Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis (Stuttg). 2016 Jul;48(13):2065-2068. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MDL 73811 関連分類
HY-112252 関連分類
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