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製品番号: HY-111168

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MLS-2064

MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC₅₀: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 906660-74-0
分子式: C₂₂H₂₄BrCl₂N₅O₂
分子量:541.27

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MLS-2064 構造式

CAS 番号: 906660-74-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

GSK-3 アイソフォーム固有の製品をすべて表示 :

体外実験

MLS-2064 (compound 13j) (8 h) potently reduces the viability of various human tumor cell lines and embryonic kidney cell lines^[1].
MLS-2064 (48 h) induces caspase-independent cell death in SH-SY5Y cells, as its cell viability inhibitory activity is not affected by the caspase inhibitor Q-VD-OPh^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-29, HCT116 colon cancer, MDA-MB-231 breast cancer, A549 lung cancer, PC3 prostate cancer, 5L, BP8, F1, Huh7 hepatoma, HEK293 embryonic kidney cells
Concentration:

/
Incubation Time:

48 h
Result:

Exhibited the following IC₅₀ values for cell viability inhibition after 48 h: HT-29 (6.3 μM), HCT116 (5.4 μM), MDA-MB-231 (5.3 μM), A549 (5.9 μM), PC3 (6.1 μM), 5L (5.2 μM), BP8 (5.6 μM), F1 (1.7 μM), Huh7 (5.3 μM), HEK293 (5.0 μM).

化学情報

CAS 番号 906660-74-0
分子量 541.27
分子式 C₂₂H₂₄BrCl₂N₅O₂
SMILES

O=C(/C(C1=CC=C2)=C(NC3=CC=CC=C34)/C4=N/OCCN5CCNCC5)NC1=C2Br.Cl.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ferandin Y, et al. 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. J Med Chem. 2006;49(15):4638-4649. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MLS-2064

GSK-3 アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MLS-2064 関連分類

HY-111168 関連分類