モグロシドV
Based on 5 publication(s) in Google Scholar
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.76%
- CAS 番号: 88901-36-4
- 分子式: C60H102O29
- 分子量:1287.43
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Mogroside V
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生物活性
Mogroside V (20 μM, 40 h) reducs the ROS levels in in vitro maturation (IVM) oocytes[1].
Mogroside V (20 μM, 40 h) can enhance mitochondrial function in oocytes[1].
Mogroside V (1-250 μM, 24 h) promots apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells) and may be mediated through regulating the STAT3 signaling pathway[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IVM oocytes
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Concentration:20 μM
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Incubation Time:40 h
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Result:Increased the fluorescence intensity compared to control group.
Increased the red/green fluorescence intensity ratio compared to control group.
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Cell Line:IVM oocytes
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Concentration:20 μM
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Incubation Time:40 h
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Result:Increased the relative mRNA expression of SOD, CAT, PGC-1α and TFAM than in control group.
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Cell Line:PANC-1 cells
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Concentration:1-250 μM
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Incubation Time:24 h
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Result:Increased the percentage of TUNEL-positive cells ranging from 2.91% to 92.25%.
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Cell Line:PANC-1 cells
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Concentration:1-250 μM
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Incubation Time:24 h
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Result:Induced apoptosis in PANC-1 cells in a concentration- and time-dependent manner
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Cell Line:PANC-1 cells
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Concentration:0-250 μM
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Incubation Time:24 h
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Result:Increased the expression of the cyclin kinase inhibitors CDKN1A (p21WAF1) and CDKN1B (p27) in a dose-dependent manner.
Decreased the the expression of the pro-proliferative cell cycle regulators CCND1 (cyclin D1), CCNE1 (cyclin E1) and CDK2.
Suppressed phosphorylation of the kinases upstream of STAT3, including that of JAK2 and TYK2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:T2D model rats[2]
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Dosage:100 mg/kg
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Administration:Oral gavage (p.o.)
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Result:Detected 28 metabolites of mogroside V compared to the blank biological samples.
Displayed larger peak areas of metabolites in T2D rat plasma samples than those in healthy sample.
化学情報
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CAS 番号 88901-36-4
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性状 Solid
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分子量 1287.43
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分子式 C60H102O29
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Color White to off-white
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SMILES
C[C@@]([C@@](CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]1O)O)([H])O[C@@H]1CO[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C3(C)C)([H])C3=CC4)([C@@H](C[C@@]56C)O)[C@]4([H])[C@@]5(CC[C@]6([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@H](O[C@H](CO[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)[C@@H](O)[C@@H]8O)[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]9O)O)([H])O[C@@H]9CO)C
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別名
Mogroside V
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]2025 May:140:156484. PMID: 40090046 -
Cells
Identification of Natural Compounds Triggering MRGPRX2-Mediated Calcium Flux and Degranulation in RBL-2H3 Cells. [Abstract]2026 Feb 3;15(3):287. PMID: 41677650 -
Mol Neurobiol
2025 Nov 26;63(1):181. PMID: 41296106 -
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Biochem Biophys Res Commun
Mogroside V alleviates diquat-induced renal tubular epithelial cell injury via the TUG1/miR-29-3p/SIRT1 axis. [Abstract]2026 May 7:812:153560. PMID: 41833075
溶剤 & 溶解度
DMSO : 100 mg/mL (77.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (38.84 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
純度とドキュメンテーション
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データシート (286 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Nie J, et al. Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development. Theriogenology. 2020 Jan 1;141:35-40. [Content Brief]
[3]. Zhou G, et al. The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 15;1079:25-33. [Content Brief]
[4]. Liu C, et al. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. 2016 Apr 11;5(4):e217. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.7767 mL | 3.8837 mL | 7.7674 mL | 19.4185 mL |
| 5 mM | 0.1553 mL | 0.7767 mL | 1.5535 mL | 3.8837 mL | |
| 10 mM | 0.0777 mL | 0.3884 mL | 0.7767 mL | 1.9419 mL | |
| 15 mM | 0.0518 mL | 0.2589 mL | 0.5178 mL | 1.2946 mL | |
| 20 mM | 0.0388 mL | 0.1942 mL | 0.3884 mL | 0.9709 mL | |
| 25 mM | 0.0311 mL | 0.1553 mL | 0.3107 mL | 0.7767 mL | |
| 30 mM | 0.0259 mL | 0.1295 mL | 0.2589 mL | 0.6473 mL | |
| DMSO | 40 mM | 0.0194 mL | 0.0971 mL | 0.1942 mL | 0.4855 mL |
| 50 mM | 0.0155 mL | 0.0777 mL | 0.1553 mL | 0.3884 mL | |
| 60 mM | 0.0129 mL | 0.0647 mL | 0.1295 mL | 0.3236 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mogroside V 関連分類
HY-N0502 関連分類
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