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製品番号: HY-N22074

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Monocillin IV

Monocillin IV is a macrolide with antibacterial and anti-HIV-1 activities, originally isolated and identified from the metabolites of Monocillium nordinii. Monocillin IV is an inhibitor of HIV-1 Tat protein transactivation, with an IC₅₀ of 5.0 µM. Monocillin IV inhibits HIV-1 viral replication by blocking the Tat transactivation pathway. Monocillin IV exhibits moderate antibacterial activity, with an MIC of 25.6 µg/mL against Xanthomonas campestris pv. campestris . Monocillin IV can be used for research on black rot and HIV-1 infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 75207-14-6
分子式: C₁₈H₂₂O₅
分子量:318.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Monocillin IV 構造式

CAS 番号: 75207-14-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

HIV-1

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

HIV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	5.0 μM	Inhibition of HIV-1 Tat-dependent transactivation in Jurkat-derived 63A9 cells harboring integrated HIV-1 provirus luciferase reporter incubated 24 hrs by luciferase assay. Inhibition of HIV-1 Tat-dependent transactivation in Jurkat-derived 63A9 cells harboring integrated HIV-1 provirus luciferase reporter incubated 24 hrs by luciferase assay.	17191924
Jurkat	IC₅₀	>100 μM	Cytotoxicity against human Jurkat cells assessed as viability reduction by MTS assay. Cytotoxicity against human Jurkat cells assessed as viability reduction by MTS assay.	17191924
HeLa	IC₅₀	6.2 μM	Antiviral activity against HIV H9IIIb in P4/P5 HeLa cells containing integrated LTR-LacZ reporter assessed by β-gal substrate after 48 hrs incubation. Antiviral activity against HIV H9IIIb in P4/P5 HeLa cells containing integrated LTR-LacZ reporter assessed by β-gal substrate after 48 hrs incubation.	17191924

体外実験

Bacterial InfectionParasitic InfectionViral Infection

Bacterial Infection

Monocillin IV (0.4-204.8 µg/mL; 24 h) inhibits the growth of Xanthomonas campestris pv. campestris, with an MIC of 25.6 µg/mL^[1].

Parasitic Infection

Monocillin IV (1.25-10 mg/mL; 24 h) shows no activity against Meloidogyne incognita J2s and exhibited no nematicidal effect above 1,000 μg/mL^[2].

Viral Infection

Monocillin IV (up to 100 μM; 24 h) inhibits HIV-1 Tat-dependent transactivation in Jurkat-derived 63A9 cells with an IC₅₀ of 5 µM^[4].
Monocillin IV (up to 100 μM) exhibits no significant cytotoxicity in the Jurkat-derived cell line (63A9) (IC₅₀ >100 µM)^[4].
Monocillin IV (48 h) exhibits antiviral activity against single-cycle HIV viral replication in P4/P5 Hela cells expressing CD4 and CCR5, with an IC₅₀ of 6.2 µM^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Xanthomonas campestris pv. campestris
Concentration:

Two-fold serial dilution concentration gradient from 204.8 µg/mL to 0.4 µg/mL
Incubation Time:

24 h
Result:

Exhibited modest inhibitory effects against Xanthomonas campestris, with MIC of 25.6 µg/mL.

Related Protocols :

化学情報

CAS 番号 75207-14-6
分子量 318.36
分子式 C₁₈H₂₂O₅
SMILES

OC1=C2C(CC(CCCC/C=C/C[C@H](OC2=O)C)=O)=CC(O)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganism
Monocillium nordinii
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Qin F, et al. Antibacterial Radicicol Analogues from Pochonia chlamydosporia and Their Biosynthetic Gene Cluster. J Agric Food Chem. 2019;67(26):7266-7273.

[2]. Li Z, et al. Nematicidal glycosylated resorcylic acid lactones from the fungus Pochonia chlamydosporia PC-170 and their key biosynthetic genes. Front Microbiol. 2024;15:1385255.

[3]. Gao J, et al. Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors. Journal of natural products. 2013 May 24;76(5):824-8. [Content Brief]

[4]. Jayasuriya H, et al. Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivation. Chemistry & biodiversity. 2005 Jan;2(1):112-22.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Monocillin IV

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

HIV アイソフォーム固有の製品をすべて表示