Morindone
Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 478-29-5
- 分子式: C15H10O5
- 分子量:270.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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DNA Polymerase |
Morindone (0.39-50 μM, 24-72 h) inhibits the proliferation of KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells[1].
Morindone (10.7-19.2 μM, 72 h) induces apoptosis in HCT116 and HT29 cells[1].
Morindone (10.7-19.2 μM, 24-72 h) induces G1 phase arrest in HCT116 and HT29 cells[1].
Morindone (10.7-19.2 μM, 72 h) downregulates mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells, and downregulates mutated TP53 and BAX, while upregulates p21 in HT29 cells[1].
Morindone (28.1-35.9 μM, 60 mins) inhibits the activities of animal A-family, B-family and Y-family DNA polymerases with IC50 values of 28.1-35.9 μM[2].
Morindone (24 h) inhibits the proliferation of human colon cancer HCT116 cells with an LD50of 32.2 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells
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Concentration:0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 and 50 μM
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Incubation Time:24, 48 and 72 h
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Result:Showed 3.06% proliferation inhibition in HCT116 cells at 3.12 μM for 24 h and complete proliferation inhibition at 50 μM for 72 h.
Exhibited 20.5% inhibition at 0.78 μM for 24 h and over 90% inhibition at 12.5-50 μM for 72 h in HT29 cells.
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Cell Line:HCT116 and HT29 cells
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Concentration:10.7 μM for HCT116, 19.2 μM for HT29
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Incubation Time:72 h
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Result:Downregulated mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells.
Downregulated mutated TP53 and BAX, while upregulates p21 in HT29 cells.
化学情報
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CAS 番号 478-29-5
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分子量 270.24
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分子式 C15H10O5
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SMILES
O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Morindone 関連分類
HY-178224 関連分類
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